Cheap Flights from Des Moines to San Antonio
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Des Moines
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Prices updated 24 days ago
486,190 searches this week
171 airlines compared
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Fares are subject to change and may not be available for all dates. (Data last updated May 29, 2026.)
Today’s best flight deals from Des Moines to San Antonio
Explore current cheapest deals departing from Des Moines to San Antonio
Round trip
Sort by: Cheapest
October 26 - October 29
DSM - San Antonio
$417
$266
Round trip
August 18 - August 20
DSM - San Antonio
$376
$293
Round trip
July 20 - August 18
DSM - San Antonio
$315
$300
Round trip
August 10 - August 18
DSM - San Antonio
$346
$300
Round trip
October 14 - October 20
DSM - San Antonio
$403
$301
Round trip
July 27 - August 18
DSM - San Antonio
$314
$307
Round trip
September 8 - September 11
DSM - San Antonio
$353
$318
Round trip
September 23 - September 27
DSM - San Antonio
$359
$336
Round trip
September 18 - September 21
DSM - San Antonio
$356
$345
Round trip
September 3 - September 6
DSM - San Antonio
$350
$347
Round trip
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Route Intelligence — 486,190 Searches this Week
Insights for flights from Des Moines to San Antonio
How much is a round trip from Des Moines to San Antonio
Regular price: $348 - $633
Prices for flights from Des Moines to San Antonio are currently below the regular range.
The regular price range for flights from Des Moines to San Antonio is typically between $348 and $633. The current lowest deal is $266 with Frontier Airlines, for travel from Oct 26 to Oct 29.
now $266
Low $348
High $633
The cheapest time to fly from Des Moines to San Antonio
The cheapest month to fly from Des Moines to San Antonio is October, with a median price of $343. The most expensive month is January, with a median price of $487. Prices are generally lower from April to November.
October
Flights from $343
January
Flights from $487
Direct flights from Des Moines to San Antonio
Frontier Airlines
United Airlines
Allegiant Air
American Airlines
Last-minute flights going from Des Moines to San Antonio
Thu, Jun 18
DSM - San Antonio
Des Moines (DSM) - San Antonio (SAT)
Allegiant Air
$464
$845
One-way
Thu, Jun 18
DSM - San Antonio
Des Moines (DSM) - San Antonio (SAT)
Allegiant Air
$512
$873
One-way
Fri, Jun 26
DSM - San Antonio
Des Moines (DSM) - San Antonio (SAT)
American Airlines
$437
$424
One-way
Fri, Jun 26
DSM - San Antonio
Des Moines (DSM) - San Antonio (SAT)
Allegiant Air
$441
$616
One-way
Tue, Jun 30
DSM - San Antonio
Des Moines (DSM) - San Antonio (SAT)
United Airlines
$375
$416
One-way
Sat, Jul 4
DSM - San Antonio
Des Moines (DSM) - San Antonio (SAT)
American Airlines
$357
$382
One-way
Biggest price drops on these dates for flights from Des Moines to San Antonio
Oct 26 - Oct 29
$417 → $266
36%
Oct 14 - Oct 20
$403 → $301
25%
Aug 18 - Aug 20
$376 → $293
22%
Aug 10 - Aug 18
$346 → $300
13%
Popular Airports to fly from Des Moines to San Antonio
Des Moines - San Antonio route insights
💸 Price insights
Recent fares are below the typical level
Recent fares from Des Moines to San Antonio are currently below the typical level.
📅 Best time to fly
October is historically cheapest
Historically, October is the cheapest month to fly from Des Moines to San Antonio, with a median price of $343.
⏱️ Flight duration
Connecting flights take 9h 22m
Flights from Des Moines to San Antonio typically take 9h 22m, with 2 stopovers.
✈️ Airlines & availability
Connecting flights only
There are no direct flights available; all routes include at least one stopover.
🏆 Airline highlight
Frontier Airlines offers deals
Frontier Airlines has historically offered the most deals for flights on this route.
🎯 Booking tip
Deals are frequent
Deals for flights from Des Moines to San Antonio are frequent, with almost one deal per day.
Des Moines main airports to depart from
Des Moines International (DSM)
Des Moines International Airport is a great choice for flights from Des Moines to San Antonio.
📍 ~10 km from city center (reachable by car)
💸 Flights from ~$266
San Antonio main airports to arrive at
San Antonio International (SAT)
San Antonio International Airport is a convenient arrival choice for flights from Des Moines to San Antonio.
📍 ~15 km from San Antonio city center (reachable by car)
💸 Flights from ~$266
Airports nearby San Antonio used as alternative
Austin–Bergstrom International (AUS)
Consider Austin (AUS) for significantly more direct flight options, despite potential heavy traffic on I-35.
📍 ~120 km from San Antonio (reachable by car)
💸 Flights from ~$97
Corpus Christi International (CRP)
Corpus Christi (CRP) offers additional options for travelers heading toward the Gulf Coast.
📍 ~200 km from San Antonio (reachable by car)
💸 Flights from ~$290
Laredo International (LRD)
Laredo (LRD) provides reliable domestic service within the US with a straightforward drive.
📍 ~200 km from San Antonio (reachable by car)
💸 Flights from ~$320
Killeen–Fort Hood Regional (GRK)
Killeen (GRK) is an alternative for travelers on the north side of San Antonio with a less congested terminal.
📍 ~140 km from San Antonio (reachable by car)
💸 Flights from ~$630
Business & First Class Flight Deals to San Antonio
Discover luxury on the budget with premium cabin class on flights from Des Moines to San Antonio.
Elite
Best Elite deals to San Antonio
Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.
From DSM
Elite
Sep 14
San Antonio, United States
81% AI deal score
$1,454
$786
Save $668
From DSM
Elite
Jul 03
San Antonio, United States
77% AI deal score
$1,290
$903
Save $387
From DSM
Elite
Jul 02
San Antonio, United States
76% AI deal score
$1,273
$903
Save $370
From DSM
Elite
Jun 25
San Antonio, United States
71% AI deal score
$1,316
$1,008
Save $308
From DSM
Elite
Sep 14
San Antonio, United States
70% AI deal score
$1,435
$1,015
Save $420
From DSM
Elite
Jun 21
San Antonio, United States
68% AI deal score
$1,368
$1,152
Save $216
From DSM
Elite
Jun 18
San Antonio, United States
68% AI deal score
$1,393
$1,213
Save $180
From DSM
Elite
Nov 21
San Antonio, United States
42% AI deal score
$1,537
From DSM
Elite
Sep 14
San Antonio, United States
37% AI deal score
$2,893