Cheap Flights from Des Moines to Syracuse
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Deals from
Des Moines
RatePunk searches hundreds of travel sites at once for deals on flights to Syracuse
Prices updated 24 days ago
486,190 searches this week
171 airlines compared
80%+ AI score for best value
Fares are subject to change and may not be available for all dates. (Data last updated May 29, 2026.)
Today’s best flight deals from Des Moines to Syracuse
Explore current cheapest deals departing from Des Moines to Syracuse
Round trip
Sort by: Cheapest
July 3 - July 4
DSM - Syracuse
$464
$238
Round trip
October 19 - November 13
DSM - Syracuse
$447
$239
Round trip
November 2 - November 13
DSM - Syracuse
$447
$244
Round trip
November 9 - November 13
DSM - Syracuse
$471
$252
Round trip
October 19 - November 6
DSM - Syracuse
$449
$254
Round trip
October 26 - November 13
DSM - Syracuse
$454
$254
Round trip
November 2 - November 6
DSM - Syracuse
$473
$260
Round trip
October 19 - November 16
DSM - Syracuse
$447
$272
Round trip
October 19 - November 9
DSM - Syracuse
$447
$272
Round trip
November 8 - November 13
DSM - Syracuse
$468
$296
Round trip
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Route Intelligence — 486,190 Searches this Week
How much is a round trip from Des Moines to Syracuse
Regular price: $396 - $751
Prices are currently below the regular range.
The regular price range for flights from Des Moines to Syracuse is between $396 and $751. The current lowest deal is $238 with Allegiant Air, for travel from Jul 3-Jul 4.
now $238
Low $396
High $751
The cheapest time to fly from Des Moines to Syracuse
The cheapest month to fly from Des Moines to Syracuse is April, with a median price of $141. The most expensive month is May, with a median price of $311. Prices are generally lower from April to May.
April
Flights from $141
May
Flights from $311
Direct flights from Des Moines to Syracuse
Allegiant Air
United Airlines
JetBlue Airways
Deutsche Luft Hansa
Last-minute flights going from Des Moines to Syracuse
Thu, Jul 2
DSM - Syracuse
Des Moines (DSM) - Syracuse (SYR)
United Airlines
$472
$403
One-way
Fri, Jul 3
DSM - Syracuse
Des Moines (DSM) - Syracuse (SYR)
Allegiant Air
$464
$238
One-way
Sat, Jul 11
DSM - Syracuse
Des Moines (DSM) - Syracuse (SYR)
Deutsche Luft Hansa
$429
$330
One-way
Thu, Jul 16
DSM - Syracuse
Des Moines (DSM) - Syracuse (SYR)
Allegiant Air
$429
$328
One-way
Fri, Jul 17
DSM - Syracuse
Des Moines (DSM) - Syracuse (SYR)
Allegiant Air
$429
$311
One-way
Thu, Jul 23
DSM - Syracuse
Des Moines (DSM) - Syracuse (SYR)
Deutsche Luft Hansa
$415
$637
One-way
Biggest price drops on these dates for flights from Des Moines to Syracuse
Jul 3 - Jul 4
$464 → $238
49%
Nov 9 - Nov 13
$471 → $252
47%
Nov 2 - Nov 6
$473 → $260
45%
Oct 19 - Nov 13
$447 → $239
47%
Popular Airports to fly from Des Moines to Syracuse
Des Moines - Syracuse route insights
💸 Price insights
Recent fares are below the typical level
Recent fares from Des Moines to Syracuse are below the typical level at $238.
📅 Best time to fly
Fly in April for the best prices
Historically, April is the cheapest month to fly, with a median price of $141.
⏱️ Flight duration
Connecting flights average 11h 16m
Flights from Des Moines to Syracuse typically involve connecting, with a median duration of 11h 16m.
✈️ Airlines & availability
Connecting flights are dominant
This route is connecting-dominant, with 1 stopover being typical for deals.
🏆 Airline highlight
Allegiant Air offers deals
Allegiant Air has historically offered 23 deals on connecting flights for this route.
🎯 Booking tip
Deals are rare for this route
Deals for flights from Des Moines to Syracuse are historically rare, appearing infrequently.
Des Moines main airports to depart from
Des Moines International (DSM)
Des Moines International Airport is a convenient departure point for flights to Syracuse.
📍 ~8 km from Des Moines city center.
💸 Flights from ~$238
Syracuse main airports to arrive at
Syracuse Hancock International (SYR)
Syracuse Hancock International Airport is a convenient arrival choice for flights from Des Moines.
📍 ~10 km from Syracuse city center (reachable by car)
💸 Flights from ~$238
Airports nearby Syracuse used as alternative
Greater Rochester International (ROC)
Greater Rochester International Airport can be a useful alternative due to its proximity and similar service levels.
📍 ~100 km from Syracuse (reachable by car)
💸 Flights from ~$319
Albany International (ALB)
Albany International Airport offers a major regional hub with extensive domestic connectivity and frequent service.
📍 ~200 km from Syracuse (reachable by car)
💸 Flights from ~$255
Buffalo Niagara International (BUF)
Buffalo Niagara International Airport is the largest airport in the region with diverse flight options and competitive pricing.
📍 ~250 km from Syracuse (reachable by car)
💸 Flights from ~$251
Ithaca Tompkins Regional (ITH)
Ithaca Tompkins Regional Airport is the closest alternative and offers a smaller, faster terminal experience.
📍 ~80 km from Syracuse (reachable by car)
💸 Flights from ~$460
Wilkes-Barre/Scranton International (AVP)
Wilkes-Barre/Scranton International Airport provides an alternative option heading south into Pennsylvania with reliable regional service.
📍 ~200 km from Syracuse (reachable by car)
💸 Flights from ~$292
Business & First Class Flight Deals to Syracuse
Discover luxury on the budget with premium cabin class on flights from Des Moines to Syracuse.
Elite
Best Elite deals to Syracuse
Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.
From DSM
Elite
Jun 25
Syracuse, United States
66% AI deal score
$1,361
$1,285
Save $76