To Panama City

Cheap Flights from Guayaquil to Panama City

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Guayaquil

RatePunk searches hundreds of travel sites at once for deals on flights to Panama City

Prices updated 24 days ago

486,190 searches this week

171 airlines compared

80%+ AI score for best value

Fares are subject to change and may not be available for all dates. (Data last updated May 29, 2026.)

Today’s best flight deals from Guayaquil to Panama City

Explore current cheapest deals departing from Guayaquil to Panama City

Round trip

Sort by: Cheapest

June 18 - June 20

Cheapest

Best

Earliest

GYE - Panama

$499

$293

Round trip

June 18 - June 21

Cheapest

Earliest

GYE - Panama

$494

$293

Round trip

June 18 - June 22

Cheapest

Earliest

GYE - Panama

$491

$293

Round trip

June 18 - June 25

Cheapest

Earliest

GYE - Panama

$435

$293

Round trip

June 19 - June 21

Cheapest

Best

GYE - Panama

$499

$293

Round trip

June 19 - June 22

Cheapest

GYE - Panama

$494

$293

Round trip

June 19 - June 23

Cheapest

GYE - Panama

$491

$293

Round trip

June 19 - June 29

Cheapest

GYE - Panama

$410

$293

Round trip

June 19 - July 6

Cheapest

GYE - Panama

$385

$293

Round trip

June 19 - July 8

Cheapest

GYE - Panama

$384

$293

Round trip

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Route Intelligence — 486,190 Searches this Week

Insights for flights from Guayaquil to Panama City

For flights from Guayaquil to Panama City, right now fares are below the typical level. Recent fares for this route typically range from $908–$1630, with a median of $1171. However, 0% of recent fares were classified as a good price, indicating that finding exceptional value can be challenging. New deals for this route show up several times a week, so consistent monitoring can be beneficial.

When considering the cheapest time to fly from Guayaquil to Panama City, August stands out with a median fare of $607. Other cost-effective months include March, with a median fare of $847, and September, where the median fare is $891. These months offer significantly lower prices compared to the overall median for the route.

A typical journey from Guayaquil to Panama City takes about 23h 53m, including connections. This is a medium-haul route, covering a distance of 3670 km. Given that most itineraries connect at least once, this median duration reflects the time spent on layovers in addition to flight time.

For this route, most itineraries connect at least once, as 0% of recent fares were for direct flights from Guayaquil to Panama City. When connections are involved, the typical number of stopovers is 3. This means travelers should expect longer journey times due to multiple stops.

How much is a round trip from Guayaquil to Panama City

Regular price: $359 - $524

Prices for flights from Guayaquil to Panama are currently below the regular range.

The regular price range for this route is $359 to $524. The current lowest deal is $293 for a roundtrip from June 18 to June 20, available via Kayak.

now $293

Low $359

High $524

The cheapest time to fly from Guayaquil to Panama City

The cheapest month to fly from GYE to ECP is August, with a median price of $607. The most expensive month is December, with a median price of $2312. Prices are generally lower from January to September.

August

Cheapest

Flights from $607

December

Most Expensive

Flights from $2,312

Jan

Mar

Apr

May

Jun

Jul

Aug

Sep

Oct

Dec

Direct flights from Guayaquil to Panama City

Copa Airlines

Last-minute flights going from Guayaquil to Panama City

Thu, Jun 18

⌛ Last-Minute

GYE - Panama

Guayaquil (GYE) - Panama (PTY)

$499

$293

One-way

Thu, Jun 18

⌛ Last-Minute

GYE - Panama

Guayaquil (GYE) - Panama (PTY)

$494

$293

One-way

Thu, Jun 18

⌛ Last-Minute

GYE - Panama

Guayaquil (GYE) - Panama (PTY)

$491

$293

One-way

Thu, Jun 18

⌛ Last-Minute

GYE - Panama

Guayaquil (GYE) - Panama (PTY)

$435

$293

One-way

Fri, Jun 19

⌛ Last-Minute

GYE - Panama

Guayaquil (GYE) - Panama (PTY)

$499

$293

One-way

Fri, Jun 19

⌛ Last-Minute

GYE - Panama

Guayaquil (GYE) - Panama (PTY)

$494

$293

One-way

Biggest price drops on these dates for flights from Guayaquil to Panama City

2 nights

Jun 18 - Jun 20

$499 → $293

41%

2 nights

Jun 19 - Jun 21

$499 → $293

41%

2 nights

Jun 20 - Jun 22

$496 → $293

41%

3 nights

Jun 18 - Jun 21

$494 → $293

41%

Popular Airports to fly from Guayaquil to Panama City

Guayaquil - Panama City route insights

💸 Price insights

Recent fares are below the typical level

Recent fares from Guayaquil to Panama City are below the typical level, with deals around $293.

📅 Best time to fly

August is historically cheapest at $607

Historically, August is the cheapest month to fly from Guayaquil to Panama City, at $607.

⏱️ Flight duration

Typically 23h 53m with connections

The typical flight duration from Guayaquil to Panama City is 23 hours 53 minutes with 3 stopovers.

✈️ Airlines & availability

Connecting flights are dominant

Connecting flights are dominant on this route, with no direct flights typically available.

🏆 Airline highlight

Copa Airlines has offered direct flights

Copa Airlines has offered direct flights from Guayaquil to Panama City in the past.

🎯 Booking tip

Deals appear regularly

Deals for flights from Guayaquil to Panama City appear regularly, about 0.47 deals per day.

Guayaquil main airports to depart from

José Joaquín de Olmedo International (GYE)

Cheapest

Fly from Guayaquil to Panama City with good value fares from José Joaquín de Olmedo International.

📍 ~5 km from city center (reachable by car)

💸 Flights from ~$293

Panama City main airports to arrive at

Northwest Florida Beaches International (ECP)

Cheapest

Arrive at Northwest Florida Beaches International to reach Panama City and surrounding areas.

📍 ~20 km from city center (reachable by car)

💸 Flights from ~$904

Airports nearby Panama City used as alternative

Destin–Fort Walton Beach (VPS)

Destin–Fort Walton Beach Airport is a useful alternative with frequent flight options for your arrival.

📍 ~100 km from Panama City (traffic on Highway 98 can impact travel time).

💸 Flights from ~$599

Pensacola International (PNS)

Cheapest

Pensacola International Airport offers superior connectivity and a full range of cabin classes for your arrival.

📍 ~120 km from Panama City (approximately 1.5 to 2 hours drive).

💸 Flights from ~$526

Tallahassee International (TLH)

Tallahassee International Airport provides consistent regional jet service and reasonable driving distance via I-10.

📍 ~120 km from Panama City (located in a different timezone).

💸 Flights from ~$527

Dothan Regional (DHN)

Dothan Regional Airport offers a simple terminal experience for quick arrivals, with relatively close proximity.

📍 ~100 km from Panama City (very limited flight schedule and destinations).

💸 Flights from ~$2230

Montgomery Regional (MGM)

Montgomery Regional Airport provides additional carrier options for travelers heading north into Alabama.

📍 ~240 km from Panama City (significant driving distance).

💸 Flights from ~$1155

Frequently Asked Questions About Flights to Panama City

To find more affordable flights, consider being flexible with your travel dates and times. Using flight comparison sites can help you compare prices across various airlines and booking platforms. Looking into flights with layovers may also present cheaper options than direct routes.

Booking flights in advance, often several months out, can sometimes lead to better prices. However, prices can fluctuate, so monitoring fares over time may help you identify a good deal. Mid-week bookings are also sometimes associated with lower prices.

Comparing flights to and from nearby airports can sometimes uncover more economical travel options. While it may add to your ground transportation time, the potential savings on airfare can be significant. Always factor in the cost and convenience of getting to and from these alternative airports.

Related routes

Consider alternative routes from Guayaquil

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Cheap Flights from Guayaquil to Panama City

Today’s best flight deals from Guayaquil to Panama City

Unlock all 500+ flight deals to Panama City and get alerts when great deals appear

Route Intelligence — 486,190 Searches this Week

Insights for flights from Guayaquil to Panama City

How much is a round trip from Guayaquil to Panama City

The cheapest time to fly from Guayaquil to Panama City

Direct flights from Guayaquil to Panama City

Last-minute flights going from Guayaquil to Panama City

Biggest price drops on these dates for flights from Guayaquil to Panama City

Popular Airports to fly from Guayaquil to Panama City

Guayaquil - Panama City route insights

Recent fares are below the typical level

August is historically cheapest at $607

Typically 23h 53m with connections

Connecting flights are dominant

Copa Airlines has offered direct flights

Deals appear regularly

Guayaquil main airports to depart from

Panama City main airports to arrive at

Airports nearby Panama City used as alternative

Frequently Asked Questions About Flights to Panama City

How can I find cheap flights from Guayaquil to Panama City?

When should I book flights from Guayaquil to Panama City?

Should I compare nearby airports for flights from Guayaquil to Panama City?

Are direct flights from Guayaquil to Panama City always the best option?

Can flexible travel dates help on Guayaquil to Panama City flights?

What extra costs should I check before booking Guayaquil to Panama City flights?

Related routes

Consider alternative routes from Guayaquil