Are direct flights from Des Moines to Syracuse always the best option?

Direct flights offer convenience by minimizing travel time and avoiding layovers. However, they are not always the most economical choice. Flights with one or more stops can often be more affordable, depending on the route and airline.

Can flexible travel dates help on Des Moines to Syracuse flights?

Yes, being flexible with your travel dates can often lead to finding cheaper flights. Prices for airfare can vary significantly depending on the day of the week or specific time of year. Adjusting your departure or return by a few days may reveal more budget-friendly options.

What extra costs should I check before booking Des Moines to Syracuse flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. Understanding these additional expenses can help you calculate the total cost of your trip.

Flights From Des Moines

To Syracuse

Cheap Flights from Des Moines to Syracuse

Browse current best options from Des Moines. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

Des Moines

RatePunk searches hundreds of travel sites at once for deals on flights to Syracuse

Prices updated today

462 airlines compared

80%+ AI score for best value

Fares are subject to change and may not be available for all dates. (Data last updated Sep 15, 2026.)

Today’s best flight deals from Des Moines to Syracuse

Explore current cheapest deals departing from Des Moines to Syracuse

2026-11-04 – 2026-11-08
DSM - Syracuse
77% AI deal score
$429
$325
Round trip
2026-11-04 – 2026-11-09
DSM - Syracuse
77% AI deal score
$423
$325
Round trip
2026-11-05 – 2026-11-08
DSM - Syracuse
78% AI deal score
$429
$326
Round trip
2026-11-04 – 2026-11-07
DSM - Syracuse
77% AI deal score
$430
$326
Round trip
2026-11-21 – 2026-11-26
DSM - Syracuse
77% AI deal score
$430
$346
Round trip
2026-10-30 – 2026-11-01
DSM - Syracuse
73% AI deal score
$466
$368
Round trip
2027-02-05 – 2027-02-17
DSM - Syracuse
65% AI deal score
$403
$373
Round trip
2026-10-30 – 2026-11-12
DSM - Syracuse
50% AI deal score
$399
$373
Round trip
2026-10-02 – 2026-10-21
DSM - Syracuse
49% AI deal score
$389
$377
Round trip
2026-10-23 – 2026-11-01
DSM - Syracuse
66% AI deal score
$420
$379
Round trip

Des Moines to Syracuse: Overview

Insights for flights from Des Moines to Syracuse

The journey from Des Moines to Syracuse covers a distance of 1451 kilometers, classifying it as a short-haul route. Right now, fares for cheap flights from Des Moines to Syracuse are significantly below the typical level. Over a 90-day window, prices typically range from $239–$314, with a median of $311.

If you are looking for the cheapest time to fly from Des Moines to Syracuse, you will find that April is the most affordable month, with a median fare of $141. Following April, May also offers competitive pricing, with a median fare of $311.

Most itineraries for this route connect at least once. There are currently no direct flights from Des Moines to Syracuse, meaning all recent fares included at least one stopover. When connecting, the typical number of connections is 1.

A typical journey from Des Moines to Syracuse takes approximately 8h 22m, including connections. This duration accounts for itineraries that involve at least one stopover, which is characteristic of this route.

How much is a round trip from Des Moines to Syracuse

Regular price: $366 - $616

Prices are currently below the regular range for flights from Des Moines to Syracuse.

The regular price range for flights from Des Moines to Syracuse is $366 to $616. The current lowest deal is $327 with American Airlines for travel from Nov 4-Nov 8.

now $327

Low $366

High $616

The cheapest time to fly from Des Moines to Syracuse

The cheapest month to fly from Des Moines to Syracuse is October, with a median price of $361. The most expensive month is July, with a median price of $504. Prices are generally lower from August to December.

October

Cheapest

Flights from $361

July

Most Expensive

Flights from $504

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Des Moines to Syracuse

Allegiant Air

United Airlines

JetBlue Airways

Breeze Airways

Last-minute flights going from Des Moines to Syracuse

Wed, Sep 16

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$599

$541

One-way

Fri, Sep 18

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$701

$485

One-way

Sat, Sep 19

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$701

$550

One-way

Sat, Sep 26

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

American Airlines

$515

$396

One-way

Sat, Sep 26

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$466

$510

One-way

Tue, Sep 29

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$478

$479

One-way

Biggest price drops on these dates for flights from Des Moines to Syracuse

2 nights

Sep 18 - Sep 20

$701 → $485

31%

2 nights

Sep 19 - Sep 21

$701 → $550

22%

4 nights

Sep 26 - Sep 30

$515 → $396

23%

2 nights

Oct 30 - Nov 1

$466 → $357

23%

Popular Airports to fly from Des Moines to Syracuse

Des Moines - Syracuse route insights

💸 Price insights

Recent fares are below the typical level

Recent fares from Des Moines to Syracuse are below the typical level at $327.

📅 Best time to fly

April offers the lowest median price

Historically, April is the cheapest month to fly, with a median price of $141.

⏱️ Flight duration

Connecting flights average 8h 22m

Connecting flights from Des Moines to Syracuse typically take 8h 22m.

✈️ Airlines & availability

Connecting flights are dominant

There are no direct flights; connecting flights are the only option for this route.

🏆 Airline highlight

American Airlines has a recent deal

American Airlines recently offered a roundtrip for $327 from Des Moines to Syracuse.

🎯 Booking tip

Deals are rare on this route

Deals for flights from Des Moines to Syracuse are historically rare.

Des Moines main airports to depart from

Des Moines International (DSM)

Cheapest

Des Moines International Airport is a convenient option for flights from Des Moines to Syracuse.

📍 ~8 km from Des Moines (reachable by car)

💸 Flights from ~$273

Syracuse main airports to arrive at

Syracuse Hancock International (SYR)

Cheapest

Syracuse Hancock International Airport is a convenient arrival choice for flights to Syracuse.

📍 ~8 km from city center (reachable by car)

💸 Flights from ~$270

Airports nearby Syracuse used as alternative

Greater Rochester International (ROC)

Greater Rochester International is a practical alternative due to its proximity and service levels.

📍 ~135 km from Syracuse (reachable by car, accounting for tolls and potential winter weather).

💸 Flights from ~$288

Business & First Class Flight Deals to Syracuse

Discover luxury on the budget with premium cabin class on flights from Des Moines to Syracuse.

Elite

Best Elite deals to Syracuse

Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.

From DSM

Elite

Oct 02

Syracuse, United States

80% AI deal score

$1,581

$944

Save $637

United Airlines

Business Class

From DSM

Elite

Nov 07

Syracuse, United States

79% AI deal score

$1,296

$809

Save $487

United Airlines

Business Class

Frequently Asked Questions About Flights to Syracuse

To find more affordable flights, consider being flexible with your travel dates and times. Comparing prices across different airlines and booking sites can also help you discover better deals. Looking into flights with layovers may sometimes present lower fares than direct routes.

Booking flights in advance often provides more competitive prices, though last-minute deals can sometimes appear. Prices may fluctuate, so monitoring fares over time can help you decide when to purchase. Mid-week bookings are sometimes associated with better availability.

Comparing nearby airports at both your origin and destination can sometimes uncover additional flight options or more favorable prices. While it may add to travel time, the potential savings could be significant. Always factor in the cost and convenience of ground transportation to and from alternative airports.

Des Moines to Syracuse: Overview

Insights for flights from Des Moines to Syracuse

How much is a round trip from Des Moines to Syracuse

Regular price: $366 - $616

Prices are currently below the regular range for flights from Des Moines to Syracuse.

The regular price range for flights from Des Moines to Syracuse is $366 to $616. The current lowest deal is $327 with American Airlines for travel from Nov 4-Nov 8.

now $327

Low $366

High $616

The cheapest time to fly from Des Moines to Syracuse

October

Cheapest

Flights from $361

July

Most Expensive

Flights from $504

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Des Moines to Syracuse

Allegiant Air

United Airlines

JetBlue Airways

Breeze Airways

Last-minute flights going from Des Moines to Syracuse

Wed, Sep 16

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$599

$541

One-way

Fri, Sep 18

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$701

$485

One-way

Sat, Sep 19

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$701

$550

One-way

Sat, Sep 26

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

American Airlines

$515

$396

One-way

Sat, Sep 26

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$466

$510

One-way

Tue, Sep 29

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$478

$479

One-way

Biggest price drops on these dates for flights from Des Moines to Syracuse

2 nights

Sep 18 - Sep 20

$701 → $485

31%

2 nights

Sep 19 - Sep 21

$701 → $550

22%

4 nights

Sep 26 - Sep 30

$515 → $396

23%

2 nights

Oct 30 - Nov 1

$466 → $357

23%

Popular Airports to fly from Des Moines to Syracuse