Are direct flights from Des Moines to Syracuse always the best option?

Direct flights offer convenience by reducing travel time and avoiding layovers. However, they are not always the cheapest option. Flights with connections can sometimes be more affordable, especially if you are willing to spend extra time traveling.

Can flexible travel dates help on Des Moines to Syracuse flights?

Yes, being flexible with your travel dates can often lead to finding cheaper flights. Prices can vary significantly depending on the day of the week or specific dates. Adjusting your departure or return by a few days may result in notable savings.

What extra costs should I check before booking Des Moines to Syracuse flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. Being aware of these additional fees helps in calculating the total travel expense.

Flights From Des Moines

To Syracuse

Cheap Flights from Des Moines to Syracuse

Browse current best options from Des Moines. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

Des Moines

RatePunk searches hundreds of travel sites at once for deals on flights to Syracuse

Prices updated 2 days ago

405 airlines compared

80%+ AI score for best value

Fares are subject to change and may not be available for all dates. (Data last updated Jul 26, 2026.)

Today’s best flight deals from Des Moines to Syracuse

Explore current cheapest deals departing from Des Moines to Syracuse

2026-11-09 – 2026-12-07
DSM - Syracuse
78% AI deal score
$400
$264
Round trip
2026-10-05 – 2026-10-29
DSM - Syracuse
76% AI deal score
$399
$280
Round trip
2026-09-25 – 2026-10-04
DSM - Syracuse
75% AI deal score
$405
$300
Round trip
2026-10-02 – 2026-10-04
DSM - Syracuse
76% AI deal score
$467
$318
Round trip
2026-11-08 – 2026-12-07
DSM - Syracuse
73% AI deal score
$397
$318
Round trip
2026-10-22 – 2026-10-29
DSM - Syracuse
76% AI deal score
$458
$321
Round trip
2026-08-22 – 2026-08-28
DSM - Syracuse
78% AI deal score
$461
$327
Round trip
2026-09-05 – 2026-09-12
DSM - Syracuse
77% AI deal score
$418
$327
Round trip
2026-08-24 – 2026-08-30
DSM - Syracuse
78% AI deal score
$461
$328
Round trip
2026-08-25 – 2026-08-31
DSM - Syracuse
78% AI deal score
$461
$328
Round trip

Des Moines to Syracuse: Overview

How much is a round trip from Des Moines to Syracuse

Regular price: $348 - $612

Prices for flights from Des Moines to Syracuse are currently below the regular range.

The regular price range for this route is $348 to $612. The current lowest deal is $264 with Allegiant Air, for travel from Nov 9-Dec 7.

now $264

Low $348

High $612

The cheapest time to fly from Des Moines to Syracuse

The cheapest month to fly from DSM to SYR is October, with a median price of $361. The most expensive month is July, with a median price of $504. Prices are generally lower from August to December.

October

Cheapest

Flights from $361

July

Most Expensive

Flights from $504

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Des Moines to Syracuse

Allegiant Air

United Airlines

JetBlue Airways

Deutsche Luft Hansa

Last-minute flights going from Des Moines to Syracuse

Mon, Jul 27

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$623

$1,639

One-way

Tue, Jul 28

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

American Airlines

$618

$819

One-way

Fri, Jul 31

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$517

$584

One-way

Sat, Aug 1

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$615

$570

One-way

Tue, Aug 4

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$441

$465

One-way

Tue, Aug 4

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$434

$465

One-way

Biggest price drops on these dates for flights from Des Moines to Syracuse

3 nights

Aug 6 - Aug 9

$567 → $373

34%

2 nights

Aug 7 - Aug 9

$559 → $373

33%

4 nights

Aug 7 - Aug 11

$552 → $384

30%

2 nights

Aug 14 - Aug 16

$504 → $341

32%

Popular Airports to fly from Des Moines to Syracuse

Des Moines - Syracuse route insights

💸 Price insights

Recent fares are below the typical level

Recent fares from Des Moines to Syracuse are below the typical level at $264.

📅 Best time to fly

Fly in October for the best prices

Historically, October has been the cheapest month to fly, with a median price of $361.

⏱️ Flight duration

Connecting flights average 8h 22m

The typical flight duration with one stop from Des Moines to Syracuse is 8h 22m.

✈️ Airlines & availability

Connecting flights are dominant

Connecting flights are the only option, with Allegiant Air, United Airlines, and JetBlue Airways offering deals.

🏆 Airline highlight

Allegiant Air has the most deals

Allegiant Air historically offers the most deals for connecting flights on this route.

🎯 Booking tip

Deals are rare on this route

Deals on flights from Des Moines to Syracuse are historically rare, so book when you see a good price.

Des Moines main airports to depart from

Des Moines International (DSM)

Cheapest

Des Moines International Airport offers flights to Syracuse, providing a convenient departure point for your journey.

📍 ~8 km from Des Moines (reachable by car)

💸 Flights from ~$281

Syracuse main airports to arrive at

Syracuse Hancock International (SYR)

Cheapest

Syracuse Hancock International Airport is a convenient arrival choice for flights from Des Moines.

📍 ~8 km from Syracuse (reachable by car)

💸 Flights from ~$281

Airports nearby Syracuse used as alternative

Greater Rochester International (ROC)

Cheapest

Greater Rochester International is a practical alternative due to its proximity and service levels, despite potential Thruway tolls.

📍 ~135 km from Syracuse (reachable by car)

💸 Flights from ~$248

Business & First Class Flight Deals to Syracuse

Discover luxury on the budget with premium cabin class on flights from Des Moines to Syracuse.

Elite

Best Elite deals to Syracuse

Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.

From DSM

Elite

Aug 18

Syracuse, United States

83% AI deal score

$1,793

$869

Save $924

From DSM

Elite

Sep 02

Syracuse, United States

81% AI deal score

$1,367

$789

Save $578

From DSM

Elite

Aug 19

Syracuse, United States

78% AI deal score

$1,888

$1,105

Save $783

Frequently Asked Questions About Flights to Syracuse

To find more affordable flights, consider being flexible with your travel dates and times. Comparing prices across different airlines and booking sites can also help uncover better deals. Sometimes, flying on weekdays or during off-peak seasons may result in lower fares.

Booking flights in advance often provides more options and potentially better prices. However, last-minute deals can sometimes appear, so it's useful to monitor fare changes. Generally, planning ahead allows for more strategic booking.

Comparing nearby airports at both your origin and destination can sometimes reveal more economical flight options. While it may add to travel time, the potential savings on airfare can be significant. Always factor in ground transportation costs and convenience when considering this approach.

Des Moines to Syracuse: Overview

How much is a round trip from Des Moines to Syracuse

Regular price: $348 - $612

Prices for flights from Des Moines to Syracuse are currently below the regular range.

The regular price range for this route is $348 to $612. The current lowest deal is $264 with Allegiant Air, for travel from Nov 9-Dec 7.

now $264

Low $348

High $612

The cheapest time to fly from Des Moines to Syracuse

The cheapest month to fly from DSM to SYR is October, with a median price of $361. The most expensive month is July, with a median price of $504. Prices are generally lower from August to December.

October

Cheapest

Flights from $361

July

Most Expensive

Flights from $504

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Des Moines to Syracuse

Allegiant Air

United Airlines

JetBlue Airways

Deutsche Luft Hansa

Last-minute flights going from Des Moines to Syracuse

Mon, Jul 27

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$623

$1,639

One-way

Tue, Jul 28

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

American Airlines

$618

$819

One-way

Fri, Jul 31

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$517

$584

One-way

Sat, Aug 1

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$615

$570

One-way

Tue, Aug 4

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$441

$465

One-way

Tue, Aug 4

⌛ Last-Minute

DSM - Syracuse

Des Moines (DSM) - Syracuse (SYR)

United Airlines

$434

$465

One-way

Biggest price drops on these dates for flights from Des Moines to Syracuse

3 nights

Aug 6 - Aug 9

$567 → $373

34%

2 nights

Aug 7 - Aug 9

$559 → $373

33%

4 nights

Aug 7 - Aug 11

$552 → $384

30%

2 nights

Aug 14 - Aug 16

$504 → $341

32%

Popular Airports to fly from Des Moines to Syracuse