Are direct flights from Guatemala City to Santiago de Chile always the best option?

Direct flights are often convenient, saving time and avoiding layovers. However, they may not always be the cheapest option. Flights with one or more stops can sometimes be more affordable, depending on the route and airline. Consider your priorities for cost versus travel time.

Can flexible travel dates help on Guatemala City to Santiago de Chile flights?

Yes, being flexible with your travel dates can significantly impact flight prices. Flying on weekdays or during off-peak seasons usually offers more competitive fares than weekend or holiday travel. Even shifting your departure or return by a day or two may result in savings.

What extra costs should I check before booking Guatemala City to Santiago de Chile flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. Factor these into your total travel budget to avoid surprises.

Flights From Guatemala City

To Santiago de Chile

Cheap Flights from Guatemala City to Santiago de Chile

Browse current best options from Guatemala City. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

Guatemala City

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Prices updated 2 days ago

405 airlines compared

80%+ AI score for best value

Fares are subject to change and may not be available for all dates. (Data last updated Jul 26, 2026.)

Today’s best flight deals from Guatemala City to Santiago de Chile

Explore current cheapest deals departing from Guatemala City to Santiago de Chile

2026-08-23 – 2026-08-27
GUA - Santiago de Chile
88% AI deal score
$550
$434
Round trip
2026-09-11 – 2026-09-25
GUA - Santiago de Chile
76% AI deal score
$442
$434
Round trip
2026-08-10 – 2026-08-14
GUA - Santiago de Chile
89% AI deal score
$578
$437
Round trip
2026-08-24 – 2026-08-28
GUA - Santiago de Chile
88% AI deal score
$550
$437
Round trip
2026-08-17 – 2026-08-21
GUA - Santiago de Chile
88% AI deal score
$563
$437
Round trip
2026-08-10 – 2026-08-16
GUA - Santiago de Chile
87% AI deal score
$544
$440
Round trip
2026-09-14 – 2026-09-19
GUA - Santiago de Chile
79% AI deal score
$479
$441
Round trip
2026-10-10 – 2026-10-25
GUA - Santiago de Chile
81% AI deal score
$523
$441
Round trip
2026-10-10 – 2026-10-26
GUA - Santiago de Chile
81% AI deal score
$524
$441
Round trip
2026-09-13 – 2026-09-19
GUA - Santiago de Chile
78% AI deal score
$469
$443
Round trip

Guatemala City to Santiago de Chile: Overview

Insights for flights from Guatemala City to Santiago de Chile

For cheap flights from Guatemala City to Santiago de Chile, prices typically range from $438–$910, with a median of $680. Right now, current fares are significantly above the typical level, and only 7% of recent fares were classified as a good price. New deals appear almost daily, suggesting opportunities for savings can arise frequently.

When is the cheapest time to fly from Guatemala City to Santiago de Chile? The data indicates that December is the most affordable month, with a median fare of $342. Following closely are March, with a median of $344, and November, where the median fare is $348. These months offer the best value for travelers planning this route.

Regarding direct flights from Guatemala City to Santiago de Chile, most itineraries connect at least once, as 0% of recent fares were non-stop. For connecting itineraries, the typical number of connections is 2. This means travelers should expect to make at least two stops on their journey.

How long is the flight from Guatemala City to Santiago de Chile? A typical journey, including connections, takes about 20h 20m. Given that most itineraries involve multiple stops, this duration reflects the time spent in transit and during layovers for this long-haul route.

The distance between Guatemala City and Santiago de Chile is approximately 5,731 kilometers. This classifies the route as a long-haul journey, indicating a significant travel distance that typically involves extended flight times and often requires connecting flights.

How much is a round trip from Guatemala City to Santiago de Chile

Regular price: $485 - $969

Prices for flights from Guatemala City to Santiago de Chile are currently below the regular range.

The regular price range for this route is typically between $485 and $969. The current lowest deal is $432 with Avianca for travel from Aug 23-Aug 27.

now $432

Low $485

High $969

The cheapest time to fly from Guatemala City to Santiago de Chile

The cheapest month to fly from GUA to SCL is December, with a median price of $342. The most expensive month is October, with a median price of $748. Prices are generally lower from January to December.

December

Cheapest

Flights from $342

October

Most Expensive

Flights from $748

Jan

Feb

Mar

Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Guatemala City to Santiago de Chile

Avianca

Copa Airlines

Last-minute flights going from Guatemala City to Santiago de Chile

Wed, Aug 5

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$533

$480

One-way

Fri, Aug 7

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$566

$562

One-way

Mon, Aug 10

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Avianca

$600

$439

One-way

Mon, Aug 10

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$599

$443

One-way

Mon, Aug 10

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$552

$443

One-way

Mon, Aug 10

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Avianca

$524

$462

One-way

Biggest price drops on these dates for flights from Guatemala City to Santiago de Chile

3 nights

Aug 10 - Aug 13

$600 → $439

27%

4 nights

Aug 10 - Aug 14

$599 → $443

26%

2 nights

Aug 11 - Aug 13

$599 → $443

26%

4 nights

Aug 15 - Aug 19

$581 → $443

24%

Popular Airports to fly from Guatemala City to Santiago de Chile

Guatemala City - Santiago de Chile route insights

💸 Price insights

Recent fares are above the typical level

Recent fares for Guatemala City to Santiago de Chile are above the typical level.

📅 Best time to fly

Fly in December for the best prices

Historically, December offers the lowest median price at $342 for this route.

⏱️ Flight duration

Flights are typically 20h 20m

The median flight duration from Guatemala City to Santiago de Chile is 20h 20m.

✈️ Airlines & availability

Connecting flights are dominant

Direct flights are not available; connecting flights typically have 2 stopovers.

🏆 Airline highlight

Avianca offers deals on this route

Avianca has offered deals on this route, such as a recent fare of $432.

🎯 Booking tip

Deals appear frequently

Deals from Guatemala City to Santiago de Chile appear frequently, so check often.

Guatemala City main airports to depart from

La Aurora International (GUA)

Cheapest

Fly from GUA to SCL. This airport offers flights to Santiago de Chile.

📍 ~5 km from Guatemala City (reachable by car)

💸 Flights from ~$574

Santiago de Chile main airports to arrive at

Comodoro Arturo Merino Benítez International (SCL)

Cheapest

Comodoro Arturo Merino Benítez International Airport is the primary gateway to Santiago de Chile.

📍 ~15 km from city center (reachable by car)

💸 Flights from ~$574

Airports nearby Santiago de Chile used as alternative

Governor Francisco Gabrielli International (MDZ)

Consider Mendoza for its proximity to Santiago, offering frequent trans-Andean connections to South American hubs.

📍 ~180 km from Santiago de Chile (requires an international border crossing into Argentina)

💸 Flights from ~$723

Business & First Class Flight Deals to Santiago de Chile

92% AI deal score

$3,562

$1,636

Save $1,926

Frequently Asked Questions About Flights to Santiago de Chile

To find more affordable flights, consider being flexible with your travel dates and times. Comparing prices across different airlines and booking sites can often reveal better deals. Setting up price alerts may also help you catch drops in fares.

Booking in advance, often several months before your intended travel date, can sometimes result in lower prices. However, last-minute deals can occasionally appear, so it's wise to monitor fare trends. Prices may fluctuate based on demand and seasonality.

Comparing nearby airports can sometimes offer alternative flight options or potentially lower fares. While not always applicable, checking surrounding airports for both your origin and destination may provide more choices. Always factor in the additional travel time and cost to reach these airports.

Related routes

More routes from Guatemala City

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Flights to Santiago de Chile from other cities

Guatemala City to Santiago de Chile: Overview

Insights for flights from Guatemala City to Santiago de Chile

How much is a round trip from Guatemala City to Santiago de Chile

Regular price: $485 - $969

Prices for flights from Guatemala City to Santiago de Chile are currently below the regular range.

The regular price range for this route is typically between $485 and $969. The current lowest deal is $432 with Avianca for travel from Aug 23-Aug 27.

now $432

Low $485

High $969

The cheapest time to fly from Guatemala City to Santiago de Chile

December

Cheapest

Flights from $342

October

Most Expensive

Flights from $748

Jan

Feb

Mar

Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Guatemala City to Santiago de Chile

Avianca

Copa Airlines

Last-minute flights going from Guatemala City to Santiago de Chile

Wed, Aug 5

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$533

$480

One-way

Fri, Aug 7

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$566

$562

One-way

Mon, Aug 10

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Avianca

$600

$439

One-way

Mon, Aug 10

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$599

$443

One-way

Mon, Aug 10

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$552

$443

One-way

Mon, Aug 10

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Avianca

$524

$462

One-way

Biggest price drops on these dates for flights from Guatemala City to Santiago de Chile

3 nights

Aug 10 - Aug 13

$600 → $439

27%

4 nights

Aug 10 - Aug 14

$599 → $443

26%

2 nights

Aug 11 - Aug 13

$599 → $443

26%

4 nights

Aug 15 - Aug 19

$581 → $443

24%

Popular Airports to fly from Guatemala City to Santiago de Chile