Are direct flights from Guatemala City to Santiago de Chile always the best option?

Direct flights offer convenience by reducing travel time and avoiding layovers. However, connecting flights can sometimes be more affordable, especially for longer routes. Weigh the cost savings against the added travel duration and potential for delays when making your decision.

Can flexible travel dates help on Guatemala City to Santiago de Chile flights?

Yes, having flexible travel dates can significantly impact the price of your flight. Mid-week flights or those during the off-season are often less expensive than weekend or holiday travel. Adjusting your departure or return by a few days may result in considerable savings.

What extra costs should I check before booking Guatemala City to Santiago de Chile flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. Being aware of these additional expenses can help you budget accurately for your trip.

Flights From Guatemala City

To Santiago de Chile

Cheap Flights from Guatemala City to Santiago de Chile

Browse current best options from Guatemala City. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

Guatemala City

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Prices updated 1 day ago

461 airlines compared

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Fares are subject to change and may not be available for all dates. (Data last updated Sep 14, 2026.)

Today’s best flight deals from Guatemala City to Santiago de Chile

Explore current cheapest deals departing from Guatemala City to Santiago de Chile

2026-11-02 – 2026-11-08
GUA - Santiago de Chile
75% AI deal score
$455
$489
Round trip
2026-11-01 – 2026-11-07
GUA - Santiago de Chile
75% AI deal score
$455
$489
Round trip
2026-11-10 – 2026-11-21
GUA - Santiago de Chile
75% AI deal score
$437
$493
Round trip
2026-11-02 – 2026-11-12
GUA - Santiago de Chile
75% AI deal score
$435
$505
Round trip
2026-11-01 – 2026-11-10
GUA - Santiago de Chile
75% AI deal score
$442
$505
Round trip
2026-11-01 – 2026-11-16
GUA - Santiago de Chile
74% AI deal score
$429
$512
Round trip
2026-10-23 – 2026-10-30
GUA - Santiago de Chile
77% AI deal score
$549
$530
Round trip
2026-10-05 – 2026-10-14
GUA - Santiago de Chile
76% AI deal score
$535
$532
Round trip
2026-10-05 – 2026-10-13
GUA - Santiago de Chile
76% AI deal score
$538
$535
Round trip
2026-11-01 – 2026-11-13
GUA - Santiago de Chile
74% AI deal score
$432
$542
Round trip

Guatemala City to Santiago de Chile: Overview

Insights for flights from Guatemala City to Santiago de Chile

For cheap flights from Guatemala City to Santiago de Chile, December stands out as the most affordable month, with a median fare of just $342. Other cost-effective options include March, where the median fare is $344, and November, with a median of $348. Planning your trip during these months can significantly reduce travel costs.

Fares for flights from Guatemala City to Santiago de Chile typically range from $438 to $910, with a median price of $680. Right now, current fares are significantly above the typical level. Only 7% of recent fares were classified as a good price, indicating that finding a bargain on this route can be challenging, though new deals appear almost daily.

When flying from Guatemala City to Santiago de Chile, most itineraries connect at least once. There are no direct flights available on this route. The majority of connecting itineraries typically involve 2 stopovers, meaning you should factor in additional travel time for layovers.

A typical journey from Guatemala City to Santiago de Chile takes approximately 20h 20m, including connections. This duration accounts for the time spent on connecting flights and layovers, which are common given the lack of direct options on this long-haul route.

The distance between Guatemala City and Santiago de Chile is 5,731 kilometers, classifying this as a long-haul flight. This significant distance necessitates connecting flights and contributes to the extended journey times.

How much is a round trip from Guatemala City to Santiago de Chile

Regular price: $405 - $796

Prices for flights from Guatemala City to Santiago de Chile are currently within the regular range.

The regular price range for this route is between 405 USD and 796 USD. The current lowest deal is 484 USD with Avianca, for travel from Nov 2-Nov 8.

now $484

Low $405

High $796

The cheapest time to fly from Guatemala City to Santiago de Chile

The cheapest month to fly from GUA to SCL is December, with a median price of $342. The most expensive month is October, with a median price of $748. Prices are generally lower from January to December.

December

Cheapest

Flights from $342

October

Most Expensive

Flights from $748

Jan

Feb

Mar

Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Guatemala City to Santiago de Chile

Copa Airlines

Avianca

B&H Airlines

Maersk Air

Last-minute flights going from Guatemala City to Santiago de Chile

Mon, Sep 14

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$616

$625

One-way

Mon, Sep 14

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$532

$639

One-way

Tue, Sep 15

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$612

$640

One-way

Wed, Sep 16

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$617

$625

One-way

Thu, Sep 17

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$470

$625

One-way

Sat, Sep 19

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$487

$642

One-way

Biggest price drops on these dates for flights from Guatemala City to Santiago de Chile

5 nights

Oct 31 - Nov 5

$561 → $493

12%

7 nights

Oct 31 - Nov 7

$547 → $493

10%

4 nights

Oct 7 - Oct 11

$583 → $558

7 nights

Oct 23 - Oct 30

$549 → $533

Popular Airports to fly from Guatemala City to Santiago de Chile

Guatemala City - Santiago de Chile route insights

💸 Price insights

Recent fares are above the typical level

Recent fares for Guatemala City to Santiago de Chile are above the typical level.

📅 Best time to fly

Fly in December for the best prices

Historically, December, March, and November offer the lowest median prices for this route.

⏱️ Flight duration

Connecting flights average 20h 20m

Flights from Guatemala City to Santiago de Chile typically involve 2 stopovers, lasting 20h 20m.

✈️ Airlines & availability

Connecting flights are dominant

No direct flights are available. Connecting flights are the only option for this route.

🏆 Airline highlight

Avianca offers a recent deal at $484

Avianca recently offered a roundtrip deal for $484 from Guatemala City to Santiago de Chile.

🎯 Booking tip

Deals appear frequently

Deals for flights from Guatemala City to Santiago de Chile appear frequently.

Guatemala City main airports to depart from

La Aurora International (GUA)

Cheapest

La Aurora International Airport is a convenient option for flights from Guatemala City to Santiago de Chile.

📍 ~6 km from Guatemala City (reachable by car)

💸 Flights from ~$459

Santiago de Chile main airports to arrive at

Comodoro Arturo Merino Benítez International (SCL)

Cheapest

Comodoro Arturo Merino Benítez International Airport is the primary gateway to Santiago de Chile.

📍 ~12 km from city center (reachable by car)

💸 Flights from ~$459

Airports nearby Santiago de Chile used as alternative

Governor Francisco Gabrielli International (MDZ)

Cheapest

Santiago de Chile, Chile

94% AI deal score

$3,643

$1,893

Save $1,750

Copa Airlines

Business Class

From GUA

Elite

Oct 09

Santiago de Chile, Chile

93% AI deal score

$3,190

$1,688

Save $1,502

Avianca

Business Class

From GUA

Elite

Oct 09

Santiago de Chile, Chile

93% AI deal score

$3,349

$1,826

Save $1,523

Avianca

Business Class

From GUA

Elite

Oct 09

Santiago de Chile, Chile

93% AI deal score

$3,419

$1,826

Save $1,593

Avianca

Business Class

From GUA

Elite

Oct 09

Santiago de Chile, Chile

93% AI deal score

$3,192

$1,826

Save $1,366

Avianca

Business Class

From GUA

Elite

Oct 09

Santiago de Chile, Chile

93% AI deal score

$3,190

$1,826

Save $1,364

Avianca

Business Class

From GUA

Elite

Oct 09

Santiago de Chile, Chile

93% AI deal score

$3,220

$1,826

Save $1,394

Avianca

Business Class

From GUA

Elite

Oct 09

Santiago de Chile, Chile

93% AI deal score

$3,225

$1,826

Save $1,399

Avianca

Business Class

From GUA

Elite

Oct 09

Santiago de Chile, Chile

93% AI deal score

$3,190

$1,826

Save $1,364

Avianca

Business Class

From GUA

Elite

Oct 09

Santiago de Chile, Chile

93% AI deal score

$3,190

$1,826

Save $1,364

Avianca

Business Class

From GUA

Elite

Oct 09

Santiago de Chile, Chile

93% AI deal score

$3,293

$1,827

Save $1,466

Avianca

Business Class

Frequently Asked Questions About Flights to Santiago de Chile

To find more affordable flights, consider using flight comparison websites to check various airlines and online travel agencies. Being flexible with your travel dates and considering flights during the off-peak season can often lead to better deals. Also, signing up for fare alerts may notify you of price drops.

Booking flights in advance, often several months before your intended departure, may help you secure better prices. Prices can fluctuate, so monitoring fares over time can be beneficial. Last-minute bookings usually carry a higher cost.

Comparing nearby airports can sometimes reveal more economical flight options. While it may add to your ground transportation, the potential savings on airfare can be significant. Always factor in the total cost and travel time when considering this approach.

Related routes

More routes from Guatemala City

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Flights to Santiago de Chile from other cities

Guatemala City to Santiago de Chile: Overview

Insights for flights from Guatemala City to Santiago de Chile

How much is a round trip from Guatemala City to Santiago de Chile

Regular price: $405 - $796

Prices for flights from Guatemala City to Santiago de Chile are currently within the regular range.

The regular price range for this route is between 405 USD and 796 USD. The current lowest deal is 484 USD with Avianca, for travel from Nov 2-Nov 8.

now $484

Low $405

High $796

The cheapest time to fly from Guatemala City to Santiago de Chile

December

Cheapest

Flights from $342

October

Most Expensive

Flights from $748

Jan

Feb

Mar

Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Guatemala City to Santiago de Chile

Copa Airlines

Avianca

B&H Airlines

Maersk Air

Last-minute flights going from Guatemala City to Santiago de Chile

Mon, Sep 14

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$616

$625

One-way

Mon, Sep 14

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$532

$639

One-way

Tue, Sep 15

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$612

$640

One-way

Wed, Sep 16

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$617

$625

One-way

Thu, Sep 17

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$470

$625

One-way

Sat, Sep 19

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$487

$642

One-way

Biggest price drops on these dates for flights from Guatemala City to Santiago de Chile

5 nights

Oct 31 - Nov 5

$561 → $493

12%

7 nights

Oct 31 - Nov 7

$547 → $493

10%

4 nights

Oct 7 - Oct 11

$583 → $558

7 nights

Oct 23 - Oct 30

$549 → $533

Popular Airports to fly from Guatemala City to Santiago de Chile

Guatemala City - Santiago de Chile route insights

💸 Price insights

Recent fares are above the typical level

Recent fares for Guatemala City to Santiago de Chile are above the typical level.

📅 Best time to fly

Fly in December for the best prices

Historically, December, March, and November offer the lowest median prices for this route.

⏱️ Flight duration

Connecting flights average 20h 20m

Flights from Guatemala City to Santiago de Chile typically involve 2 stopovers, lasting 20h 20m.

✈️ Airlines & availability

Connecting flights are dominant

No direct flights are available. Connecting flights are the only option for this route.

🏆 Airline highlight

Avianca offers a recent deal at $484

Avianca recently offered a roundtrip deal for $484 from Guatemala City to Santiago de Chile.

🎯 Booking tip

Deals appear frequently

Deals for flights from Guatemala City to Santiago de Chile appear frequently.

Guatemala City main airports to depart from

La Aurora International (GUA)

Cheapest

La Aurora International Airport is a convenient option for flights from Guatemala City to Santiago de Chile.

📍 ~6 km from Guatemala City (reachable by car)

💸 Flights from ~$459

Santiago de Chile main airports to arrive at

Comodoro Arturo Merino Benítez International (SCL)

Cheapest

Comodoro Arturo Merino Benítez International Airport is the primary gateway to Santiago de Chile.

📍 ~12 km from city center (reachable by car)

💸 Flights from ~$459

Airports nearby Santiago de Chile used as alternative

Governor Francisco Gabrielli International (MDZ)

Cheapest

Consider this major international airport for its frequent connections, though it requires crossing into Argentina.

Santiago de Chile, Chile

93% AI deal score

$3,293

$1,827

Save $1,466

Avianca

Business Class

Frequently Asked Questions About Flights to Santiago de Chile

Cheap Flights from Guatemala City to Santiago de Chile

Today’s best flight deals from Guatemala City to Santiago de Chile

Guatemala City to Santiago de Chile: Overview

Insights for flights from Guatemala City to Santiago de Chile

How much is a round trip from Guatemala City to Santiago de Chile

The cheapest time to fly from Guatemala City to Santiago de Chile

Direct flights from Guatemala City to Santiago de Chile

Last-minute flights going from Guatemala City to Santiago de Chile

Biggest price drops on these dates for flights from Guatemala City to Santiago de Chile

Popular Airports to fly from Guatemala City to Santiago de Chile

Guatemala City - Santiago de Chile route insights

Recent fares are above the typical level

Fly in December for the best prices

Connecting flights average 20h 20m

Connecting flights are dominant

Avianca offers a recent deal at $484

Deals appear frequently

Guatemala City main airports to depart from

Santiago de Chile main airports to arrive at

Airports nearby Santiago de Chile used as alternative

Business & First Class Flight Deals to Santiago de Chile

Best Elite deals to Santiago de Chile

Sep 16

Sep 29

Oct 09

Oct 09

Oct 09

Oct 09

Oct 09

Oct 09

Oct 09

Oct 09

Oct 09

Oct 09

Frequently Asked Questions About Flights to Santiago de Chile

How can I find cheap flights from Guatemala City to Santiago de Chile?

When should I book flights from Guatemala City to Santiago de Chile?

Should I compare nearby airports for flights from Guatemala City to Santiago de Chile?

Are direct flights from Guatemala City to Santiago de Chile always the best option?

Can flexible travel dates help on Guatemala City to Santiago de Chile flights?

What extra costs should I check before booking Guatemala City to Santiago de Chile flights?

Related routes

More routes from Guatemala City

Flights to Santiago de Chile from other cities

Guatemala City to Santiago de Chile: Overview

Insights for flights from Guatemala City to Santiago de Chile

How much is a round trip from Guatemala City to Santiago de Chile

The cheapest time to fly from Guatemala City to Santiago de Chile

Direct flights from Guatemala City to Santiago de Chile

Last-minute flights going from Guatemala City to Santiago de Chile

Biggest price drops on these dates for flights from Guatemala City to Santiago de Chile

Popular Airports to fly from Guatemala City to Santiago de Chile

Guatemala City - Santiago de Chile route insights

Recent fares are above the typical level

Fly in December for the best prices

Connecting flights average 20h 20m

Connecting flights are dominant

Avianca offers a recent deal at $484

Deals appear frequently

Guatemala City main airports to depart from

Santiago de Chile main airports to arrive at

Airports nearby Santiago de Chile used as alternative

Business & First Class Flight Deals to Santiago de Chile

Best Elite deals to Santiago de Chile

Sep 16

Sep 29

Oct 09

Oct 09

Oct 09

Oct 09

Oct 09

Oct 09

Oct 09

Oct 09

Oct 09

Oct 09

Frequently Asked Questions About Flights to Santiago de Chile

How can I find cheap flights from Guatemala City to Santiago de Chile?

When should I book flights from Guatemala City to Santiago de Chile?

Should I compare nearby airports for flights from Guatemala City to Santiago de Chile?