Are direct flights from Guatemala City to Santiago de Chile always the best option?

Direct flights often offer convenience by reducing travel time and avoiding layovers. However, they are not always the cheapest option. Flights with one or more connections can sometimes be significantly more affordable, especially if you are flexible with your travel schedule.

Can flexible travel dates help on Guatemala City to Santiago de Chile flights?

Yes, being flexible with your travel dates can significantly impact the price of your flight. Flying on weekdays or during off-peak seasons often results in lower fares compared to weekends or popular holiday periods. Adjusting your departure or return by even a few days may yield savings.

What extra costs should I check before booking Guatemala City to Santiago de Chile flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. Factor these into your total travel budget to avoid surprises.

Flights From Guatemala City

To Santiago de Chile

Cheap Flights from Guatemala City to Santiago de Chile

Browse current best options from Guatemala City. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

Guatemala City

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Prices updated today

485 airlines compared

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Fares are subject to change and may not be available for all dates. (Data last updated Nov 2, 2026.)

Today’s best flight deals from Guatemala City to Santiago de Chile

Explore current cheapest deals departing from Guatemala City to Santiago de Chile

2026-11-13 – 2026-11-23
GUA - Santiago de Chile
73% AI deal score
$442
$618
Round trip
2026-11-12 – 2026-11-19
GUA - Santiago de Chile
73% AI deal score
$464
$618
Round trip
2027-03-01 – 2027-03-12
GUA - Santiago de Chile
71% AI deal score
$476
$638
Round trip
2027-03-02 – 2027-03-14
GUA - Santiago de Chile
69% AI deal score
$475
$639
Round trip
2027-03-02 – 2027-03-23
GUA - Santiago de Chile
68% AI deal score
$474
$643
Round trip
2026-11-16 – 2026-11-20
GUA - Santiago de Chile
73% AI deal score
$492
$645
Round trip
2027-03-09 – 2027-03-14
GUA - Santiago de Chile
69% AI deal score
$497
$647
Round trip
2027-03-16 – 2027-03-23
GUA - Santiago de Chile
69% AI deal score
$496
$650
Round trip
2027-03-09 – 2027-03-23
GUA - Santiago de Chile
69% AI deal score
$486
$651
Round trip
2027-02-11 – 2027-02-24
GUA - Santiago de Chile
71% AI deal score
$496
$656
Round trip

Guatemala City to Santiago de Chile: Overview

Insights for flights from Guatemala City to Santiago de Chile

For those planning cheap flights from Guatemala City to Santiago de Chile, February stands out as the most economical month to fly, with a median fare of just $407. Other favorable months include August, with a median fare of $443, and September, where the median fare is $463. These months offer significantly lower prices compared to the overall typical range for this route.

Fares for flights from Guatemala City to Santiago de Chile typically range from $714 to $1166, with a median price of $903. Right now, current fares are above the typical level for this route. No recent fares were classified as a good price, suggesting that current pricing may not represent optimal value.

Most itineraries from Guatemala City to Santiago de Chile involve connections. There are no direct flights from Guatemala City to Santiago de Chile, and most itineraries connect at least once. For connecting flights, the median number of stopovers is 3.

A typical journey from Guatemala City to Santiago de Chile takes approximately 34h 43m, including connections. This duration reflects the multiple stopovers common on this long-haul route.

The distance between Guatemala City and Santiago de Chile is 5731 km, classifying this as a long-haul journey. This considerable distance contributes to the extended travel times and the necessity for connecting flights.

How much is a round trip from Guatemala City to Santiago de Chile

Regular price: $437 - $825

Prices for flights from Guatemala City to Santiago de Chile are currently within the regular range.

The regular price range for this route is between 437 USD and 825 USD. The current lowest deal is 620 USD with Copa Airlines, for travel from Nov 15-Nov 19.

now $620

Low $437

High $825

The cheapest time to fly from Guatemala City to Santiago de Chile

The cheapest month to fly from GUA to SCL is February, with a median price of $407. The most expensive month is November, with a median price of $1102. Prices are generally lower from January to September.

February

Cheapest

Flights from $407

November

Most Expensive

Flights from $1,102

Jan

Feb

May

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Guatemala City to Santiago de Chile

Copa Airlines

B&H Airlines

Maersk Air

AeroRepública

Last-minute flights going from Guatemala City to Santiago de Chile

Mon, Nov 2

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$518

$694

One-way

Thu, Nov 5

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Avianca

$533

$791

One-way

Fri, Nov 6

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Avianca

$531

$724

One-way

Fri, Nov 6

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Avianca

$532

$778

One-way

Sun, Nov 8

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$483

$842

One-way

Wed, Nov 11

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Avianca

$437

$622

One-way

Biggest price drops on these dates for flights from Guatemala City to Santiago de Chile

4 nights

Nov 15 - Nov 19

$493 → $620

26%

9 nights

Mar 18 - Mar 27

$492 → $620

26%

Feb 2 - Mar 2

$502 → $643

28%

5 nights

Mar 9 - Mar 14

$497 → $640

29%

Popular Airports to fly from Guatemala City to Santiago de Chile

Guatemala City - Santiago de Chile route insights

💸 Price insights

Recent fares are above the typical level

Recent fares for Guatemala City to Santiago de Chile are above the typical level at $620.

📅 Best time to fly

February is historically cheapest at $407

Historically, February is the cheapest month to fly from Guatemala City to Santiago de Chile.

⏱️ Flight duration

Connecting flights average 34h 43m

Connecting flights from Guatemala City to Santiago de Chile typically average 34h 43m.

✈️ Airlines & availability

No direct flights available

There are no direct flights available on this route; all flights include at least one stopover.

🏆 Airline highlight

Copa Airlines has the most deals

Copa Airlines offers the most deals for flights from Guatemala City to Santiago de Chile.

🎯 Booking tip

Deals appear regularly

Deals on flights from Guatemala City to Santiago de Chile appear regularly.

Guatemala City main airports to depart from

La Aurora International (GUA)

Cheapest

La Aurora International Airport is a good option for flights from Guatemala City to Santiago de Chile.

📍 ~6 km from city center

💸 Flights from ~$507

Santiago de Chile main airports to arrive at

Comodoro Arturo Merino Benítez International (SCL)

Cheapest

Comodoro Arturo Merino Benítez International Airport is a key arrival point for Santiago de Chile.

📍 ~12 km from city center (reachable by car)

💸 Flights from ~$490

Airports nearby Santiago de Chile used as alternative

Governor Francisco Gabrielli International (MDZ)

Governor Francisco Gabrielli International in Mendoza, Argentina, is a major international airport with frequent connections to Chile.

📍 ~200 km from Santiago de Chile (requires crossing the international border into Argentina).

💸 Flights from ~$661

Business & First Class Flight Deals to Santiago de Chile

$1,853

Save $1,178

Avianca

Business Class

Frequently Asked Questions About Flights to Santiago de Chile

To find more affordable flights, consider being flexible with your travel dates and times. Using flight comparison sites can help you compare prices across various airlines and online travel agencies. Setting up price alerts may also notify you when fares drop for your desired route.

Booking flights in advance, often several months before your intended departure, can sometimes result in lower prices. However, prices can fluctuate, so monitoring fare trends for your specific route may be beneficial. Mid-week bookings are also sometimes associated with better deals.

Comparing nearby airports at both your origin and destination can sometimes uncover more affordable flight options. Even if an alternative airport is further away, the potential savings on airfare might outweigh the additional ground transportation costs. Always factor in the total cost and convenience.

Related routes

More routes from Guatemala City

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Flights to Santiago de Chile from other cities

Guatemala City to Santiago de Chile: Overview

Insights for flights from Guatemala City to Santiago de Chile

A typical journey from Guatemala City to Santiago de Chile takes approximately 34h 43m, including connections. This duration reflects the multiple stopovers common on this long-haul route.

How much is a round trip from Guatemala City to Santiago de Chile

Regular price: $437 - $825

Prices for flights from Guatemala City to Santiago de Chile are currently within the regular range.

The regular price range for this route is between 437 USD and 825 USD. The current lowest deal is 620 USD with Copa Airlines, for travel from Nov 15-Nov 19.

now $620

Low $437

High $825

The cheapest time to fly from Guatemala City to Santiago de Chile

February

Cheapest

Flights from $407

November

Most Expensive

Flights from $1,102

Jan

Feb

May

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Guatemala City to Santiago de Chile

Copa Airlines

B&H Airlines

Maersk Air

AeroRepública

Last-minute flights going from Guatemala City to Santiago de Chile

Mon, Nov 2

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$518

$694

One-way

Thu, Nov 5

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Avianca

$533

$791

One-way

Fri, Nov 6

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Avianca

$531

$724

One-way

Fri, Nov 6

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Avianca

$532

$778

One-way

Sun, Nov 8

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Copa Airlines

$483

$842

One-way

Wed, Nov 11

⌛ Last-Minute

GUA - Santiago de Chile

Guatemala City (GUA) - Santiago de Chile (SCL)

Avianca

$437

$622

One-way

Biggest price drops on these dates for flights from Guatemala City to Santiago de Chile

4 nights

Nov 15 - Nov 19

$493 → $620

26%

9 nights

Mar 18 - Mar 27

$492 → $620

26%

Feb 2 - Mar 2

$502 → $643

28%

5 nights

Mar 9 - Mar 14

$497 → $640

29%

Popular Airports to fly from Guatemala City to Santiago de Chile