From Knoxville
Cheap Flights from Knoxville
Browse current best options from Knoxville. Become a member to unlock all deals and get alerts when new deals appear.
Deals from
Knoxville
RatePunk searches hundreds of travel sites at once for deals on flights from Knoxville
Prices updated 24 days ago
486,190 searches this week
171 airlines compared
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Fares are subject to change and may not be available for all dates. (Data last updated May 29, 2026.)
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Today’s best flight deals from Knoxville
Explore current cheapest deals departing from Knoxville
One-way
Sort by: Cheapest
TYS
Washington, D.C.
United States • Jul 2026
$175
$28
One-way
TYS
Sarasota
United States • Jul 2026
$120
$30
One-way
TYS
Jacksonville
United States • Jul 2026
$136
$30
One-way
TYS
Philadelphia
United States • Jul 2026
$120
$34
One-way
TYS
Key West
United States • Jul 2026
$141
$36
One-way
TYS
Orlando
United States • Jul 2026
$101
$39
One-way
TYS
Chicago
United States • Nov 2026
$113
$39
One-way
TYS
Punta Gorda
United States • Aug 2026
$87
$39
One-way
TYS
Orlando
United States • Aug 2026
$88
$39
One-way
TYS
Austin
United States • Aug 2026
$119
$40
One-way
Unlock all 500+ flight deals from Knoxville and get alerts when great deals appear
Origin Intelligence — 1,613 Destinations from Knoxville Tracked
Insights for flights from Knoxville
Most popular airlines from Knoxville
American Airlines
Deutsche Luft Hansa
United Airlines
Southwest Airlines
Frontier Airlines
Allegiant Air
JetBlue Airways
Alaska Airlines, Inc.
Last-minute flights going from Knoxville soon
Tue, Jun 16
TYS - Jackson
Knoxville (TYS) - Jackson (JAC)
American Airlines
$840
$436
One-way
Fri, Jun 19
TYS - Seattle
Knoxville (TYS) - Seattle (SEA)
Frontier Airlines
$971
$402
One-way
Thu, Jun 18
TYS - Bozeman
Knoxville (TYS) - Bozeman (BZN)
United Airlines
$589
$397
One-way
Tue, Jun 30
TYS - Bakersfield
Knoxville (TYS) - Bakersfield (BFL)
American Airlines
$590
$429
One-way
Tue, Jun 30
TYS - Monterey
Knoxville (TYS) - Monterey (MRY)
United Airlines
$565
$434
One-way
Sat, Jun 27
TYS - Lahore
Knoxville (TYS) - Lahore (LHE)
Qatar Airways
$1,939
$1,705
One-way
Most popular destinations to fly from Knoxville
Okinawa Island
Japan • Sep 2026
from
$887
Nagasaki
Japan • Sep 2026
from
$889
Vienna
Austria • Dec 2026
from
$765
Athens
Greece • Dec 2026
from
$784
Dubrovnik
Croatia • Sep 2026
from
$814
Mumbai
India • Jan 2027
from
$1,047
Biggest price drops on international destinations from Knoxville
TYS - Okinawa Island
$1,601 → $887
TYS - Toyama
$1,686 → $1,019
TYS - Saga
$1,519 → $923
TYS - Auckland
$1,396 → $889
Popular Airports from Knoxville
Knoxville airport insights
🎯 Booking tip
Watch fares to Washington, D.C.
Flights to Washington, D.C. start at $28 for a direct one-way trip.
📅 Cheapest travel period
Jan
Flights from Knoxville tend to be lower priced in January.
⏱️ Best time to book
2-8 months in advance
Booking 2-8 months in advance offers the best prices for flights from TYS.
✈️ Airlines to watch
American Airlines, Deutsche Luft Hansa, United Airlines, Southwest Airlines
Major US carriers and a low-cost airline offer diverse flight options from Knoxville.
💸 Cheapest deals found
From ~$28 direct / ~$57 roundtrip
The cheapest deals from TYS are to destinations within the United States, such as Washington, D.C.
🗓️ Best days to catch a deal
Fri - Sat - Thu
Flights from Knoxville are cheapest on Friday, Saturday, and Thursday, based on 74278 deals.
Knoxville main airports to depart from
McGhee Tyson (TYS)
McGhee Tyson Airport is ideal for travelers seeking convenient flights from Knoxville and surrounding areas.
📍 ~20 km from city center (reachable by car)
💸 Flights from ~$57
Airports nearby Knoxville used as alternative
Nashville International (BNA)
Nashville International offers significantly more direct domestic and international flight options and competitive pricing.
📍 ~280 km from Knoxville (reachable by car)
💸 Flights from ~$53
Hartsfield–Jackson Atlanta International (ATL)
Hartsfield–Jackson Atlanta International provides unparalleled global connectivity and is a primary hub for Delta Air Lines.
📍 ~290 km from Knoxville (reachable by car)
💸 Flights from ~$50
Charlotte Douglas International (CLT)
Charlotte Douglas International is a major American Airlines hub offering extensive East Coast and international connections.
📍 ~290 km from Knoxville (reachable by car)
💸 Flights from ~$65
Greenville–Spartanburg International (GSP)
Greenville–Spartanburg International is a larger regional airport that often features lower fares and easier navigation.
📍 ~190 km from Knoxville (reachable by car)
💸 Flights from ~$56
Asheville Regional (AVL)
Asheville Regional is the geographically closest alternative, useful for specific low-cost carrier routes.
📍 ~110 km from Knoxville (reachable by car)
💸 Flights from ~$53
Business & First Class Flight Deals from Knoxville
Discover luxury on the budget with premium cabin class on flights from Knoxville.
Elite
Best Elite deals from Knoxville
Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.
From TYS
Elite
Houston
United States • Jul 2026
92% AI deal score
$827
$519
Save $308
United Airlines
Business Class
From TYS
Elite
Denver
United States • Aug 2026
90% AI deal score
$1,089
$735
Save $354
United Airlines
Business Class
From TYS
Elite
Chicago
United States • Jun 2026
88% AI deal score
$652
$529
Save $123
United Airlines
Business Class
From TYS
Elite
Saint Andrew Parish
Dominica • Aug 2026
86% AI deal score
$3,626
$1,695
Save $1,931
Contour Airlines, +1
Business Class
From TYS
Elite
Honolulu
United States • Mar 2027
85% AI deal score
$5,028
$3,544
Save $1,484
United Airlines
Business Class
From TYS
Elite
Las Vegas
United States • Aug 2026
84% AI deal score
$1,099
$514
Save $585
Frontier
Business Class
From TYS
Elite
Los Angeles
United States • Aug 2026
84% AI deal score
$1,015
$546
Save $469
Frontier
Business Class
From TYS
Elite
Washington, D.C.
United States • Aug 2026
83% AI deal score
$974
$572
Save $402
United Airlines
Business Class
From TYS
Elite
Saint Thomas
United States • Aug 2026
82% AI deal score
$1,165
$878
Save $287
American
Business Class
From TYS
Elite
Saint Thomas
United States • Aug 2026
81% AI deal score
$1,088
$878
Save $210
American
Business Class
From TYS
Elite
Santiago de Chile
Chile • Aug 2026
80% AI deal score
$2,990
$2,455
Save $535
Delta, +1
Business Class
From TYS
Elite
San Juan
United States • Aug 2026
80% AI deal score
$1,101
$926
Save $175
American
Business Class
From TYS
Elite
Denver
United States • Aug 2026
78% AI deal score
$644
$454
Save $190
Frontier
Business Class
From TYS
Elite
Miami
United States • Nov 2026
77% AI deal score
$591
$443
Save $148
American
Business Class
From TYS
Elite
Medellín
Colombia • Nov 2026
76% AI deal score
$1,146
$981
Save $165
American
Business Class
From TYS
Elite
Aruba
Aruba • Aug 2026
76% AI deal score
$1,410
$1,169
Save $241
American
Business Class
From TYS
Elite
Bogotá
Colombia • Aug 2026
75% AI deal score
$1,066
$967
Save $99
United
Business Class
From TYS
Elite
Willemstad
Curaçao • Sep 2026
75% AI deal score
$1,478
$1,213
Save $265
American
Business Class
From TYS
Elite
Tortola
British Virgin Islands • Aug 2026
75% AI deal score
$1,629
$1,347
Save $282
American
Business Class
From TYS
Elite
Orlando
United States • Aug 2026
74% AI deal score
$719
$516
Save $203
Frontier
Business Class
From TYS
Elite
Austin
United States • Aug 2026
74% AI deal score
$699
$513
Save $186
Frontier
Business Class
From TYS
Elite
Kahului
United States • Mar 2027
74% AI deal score
$4,895
$3,695
Save $1,200
United Airlines
Business Class
From TYS
Elite
Cartagena
Colombia • Aug 2026
74% AI deal score
$1,141
$987
Save $154
American
Business Class
From TYS
Elite
Cartagena
Colombia • Aug 2026
73% AI deal score
$1,063
$982
Save $81
American
Business Class
From TYS
Elite
San Francisco
United States • Aug 2026
72% AI deal score
$1,174
$1,157
Save $17
Delta
Business Class
From TYS
Elite
San Juan
United States • Aug 2026
71% AI deal score
$975
$926
Save $49
American
Business Class
From TYS
Elite
Las Vegas
United States • Aug 2026
71% AI deal score
$1,104
$1,054
Save $50
Delta
Business Class
From TYS
Elite
Anguilla
Anguilla • Jul 2026
71% AI deal score
$2,700
$2,280
Save $420
Cape Air, +1
Business Class
From TYS
Elite
Seattle
United States • Oct 2026
70% AI deal score
$1,146
American
Business Class
From TYS
Elite
Philadelphia
United States • Jul 2026
68% AI deal score
$652
$557
Save $95
Frontier
Business Class
From TYS
Elite
Los Angeles
United States • Aug 2026
67% AI deal score
$1,057
United
Business Class
From TYS
Elite
San Diego
United States • Aug 2026
67% AI deal score
$1,103
Delta
Business Class
From TYS
Elite
Washington, D.C.
United States • Dec 2026
66% AI deal score
$508
$436
Save $72
American
Business Class
From TYS
Elite
Washington, D.C.
United States • Dec 2026
66% AI deal score
$513
$436
Save $77
American
Business Class
From TYS
Elite
New Orleans
United States • Oct 2026
66% AI deal score
$709
$627
Save $82
Delta
Business Class