To Panama City

Cheap Flights from Medellín to Panama City

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Medellín

RatePunk searches hundreds of travel sites at once for deals on flights to Panama City

Prices updated 24 days ago

486,190 searches this week

171 airlines compared

80%+ AI score for best value

Fares are subject to change and may not be available for all dates. (Data last updated May 29, 2026.)

Today’s best flight deals from Medellín to Panama City

Explore current cheapest deals departing from Medellín to Panama City

Round trip

Sort by: Cheapest

July 18 - July 22

Cheapest

MDE - Panama City

$499

$767

Round trip

July 13 - July 30

Best

MDE - Panama City

$448

$771

Round trip

July 12 - July 31

Earliest

MDE - Panama City

$445

$798

Round trip

July 13 - July 31

MDE - Panama City

$446

$798

Round trip

July 14 - July 30

MDE - Panama City

$445

$929

Round trip

July 14 - July 29

MDE - Panama City

$450

$977

Round trip

July 14 - July 31

MDE - Panama City

$448

$1,004

Round trip

July 12 - July 29

Earliest

MDE - Panama City

$448

$1,017

Round trip

July 28 - August 15

MDE - Panama City

$449

$1,026

Round trip

July 28 - August 15

EOH - Panama City

$463

$1,074

Round trip

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Route Intelligence — 486,190 Searches this Week

Insights for flights from Medellín to Panama City

For travelers looking for cheap flights from Medellín to Panama City, fares typically range from $985–$1486, with a median of $1211. Right now, current fares are below the typical level, though only 0% of recent fares were classified as a good price. New deals appear almost daily, offering frequent opportunities to find flights.

When is the cheapest time to fly from Medellín to Panama City? The most affordable month to fly is November, with a median fare of $484. Following closely are October, with a median of $741, and September, where the median fare is $773. These months present the best opportunities for lower prices.

Most itineraries for this route are connecting flights, as 0% of recent fares were non-stop. For those itineraries that include connections, the typical number of stopovers is 3. This means you should expect at least one stop on your journey.

How long is the flight from Medellín to Panama City? A typical journey from Medellín to Panama City, including connections, takes approximately 22h 16m. This duration reflects the prevalence of connecting flights on this route.

The route from Medellín to Panama City covers a distance of 2901 kilometers, classifying it as a medium-haul journey. This distance typically involves several hours of travel, often with layovers.

How much is a round trip from Medellín to Panama City

Regular price: $386 - $703

Prices for flights from Medellín to Panama City are currently above the regular range.

The regular price range for this route is between 386 USD and 703 USD. The current lowest deal is 771 USD with United Airlines, for travel from July 13 to July 30, 2026.

now $771

Low $386

High $703

The cheapest time to fly from Medellín to Panama City

The cheapest month to fly from MDE to ECP is November, with a median price of $484. The most expensive month is March, with a median price of $1464. Prices are generally lower from January to November.

November

Cheapest

Flights from $484

March

Most Expensive

Flights from $1,464

Jan

Mar

Apr

May

Jun

Jul

Sep

Oct

Nov

Direct flights from Medellín to Panama City

AeroRepública

Copa Airlines

Last-minute flights going from Medellín to Panama City

Tue, Jun 23

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

AeroRepública, Aeroenlaces Nacionales, Aeroméxico

$601

$1,164

One-way

Wed, Jun 24

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

Aeroméxico

$586

$1,189

One-way

Sun, Jul 12

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

United Airlines

$445

$798

One-way

Sun, Jul 12

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

United Airlines

$448

$1,017

One-way

Mon, Jul 13

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

United Airlines

$448

$771

One-way

Mon, Jul 13

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

United Airlines

$446

$798

One-way

Biggest price drops on these dates for flights from Medellín to Panama City

17 nights

Jul 13 - Jul 30

$448 → $771

72%

18 nights

Jul 13 - Jul 31

$446 → $798

79%

19 nights

Jul 12 - Jul 31

$445 → $798

79%

16 nights

Jul 14 - Jul 30

$445 → $929

109%

Popular Airports to fly from Medellín to Panama City

Medellín - Panama City route insights

💸 Price insights

Recent fares are above the typical level.

Recent fares from Medellín to Panama City are above the typical level at $771.

📅 Best time to fly

Fly in November for the best prices.

Historically, November is the cheapest month to fly, with a median price of $484.

⏱️ Flight duration

Connecting flights take 22h 16m on average.

Flights from Medellín to Panama City typically involve 3 stopovers, with a median duration of 22h 16m.

✈️ Airlines & availability

No direct flights available for this route.

There are no direct flights available; all routes include at least one stopover.

🏆 Airline highlight

United Airlines offers a current deal.

United Airlines has a current deal for $771 from Medellín to Panama City via kiwi.

🎯 Booking tip

Deals appear frequently for this route.

Deals for flights from Medellín to Panama City appear frequently, about 0.57 deals per day.

Medellín main airports to depart from

José María Córdova International (MDE)

Cheapest

José María Córdova International is a good option for flights from Medellín to Panama City.

📍 ~18 km from Medellín (reachable by car)

💸 Flights from ~$767

Olaya Herrera (EOH)

Olaya Herrera is an alternative for flights from Medellín to Panama City.

📍 ~3 km from Medellín (reachable by car)

💸 Flights from ~$1084

Panama City main airports to arrive at

Northwest Florida Beaches International (ECP)

Cheapest

ECP is a convenient arrival airport for Panama City, offering access to the Florida Gulf Coast.

📍 ~20 km from Panama City (reachable by car)

💸 Flights from ~$767

Airports nearby Panama City used as alternative

Destin–Fort Walton Beach (VPS)

Destin–Fort Walton Beach can be a useful alternative, offering frequent flight options to Panama City.

📍 ~90 km from Panama City (traffic on Highway 98 can significantly impact travel time).

💸 Flights from ~$597

Pensacola International (PNS)

Pensacola International is a reliable alternative for major carrier networks with superior connectivity.

📍 ~135 km from Panama City (approximately 1.5 to 2 hours drive).

💸 Flights from ~$490

Tallahassee International (TLH)

Cheapest

Tallahassee International offers consistent regional jet service and reasonable driving distance via I-10.

📍 ~140 km from Panama City (located in a different timezone).

💸 Flights from ~$471

Dothan Regional (DHN)

Dothan Regional offers a simple terminal experience for quick departures, with relatively close proximity.

📍 ~100 km from Panama City (very limited flight schedule and destinations).

💸 Flights from ~$2109

Montgomery Regional (MGM)

Montgomery Regional provides additional carrier options for travelers heading north into Alabama.

📍 ~255 km from Panama City (significant driving distance exceeding 240km).

💸 Flights from ~$1138

Business & First Class Flight Deals to Panama City

Discover luxury on the budget with premium cabin class on flights from Medellín to Panama City.

Panama City, United States

49% AI deal score

$4,476

Frequently Asked Questions About Flights to Panama City

To find more affordable flights, consider being flexible with your travel dates and times. Comparing prices across different airlines and booking sites can often reveal better deals. Looking into flights with layovers instead of direct routes may also present cheaper options.

Booking flights in advance, often several weeks or months before your intended departure, can sometimes result in lower prices. Prices may fluctuate, so monitoring fares over a period can help you identify a good booking window. Weekday bookings might also offer different pricing compared to weekends.

Comparing nearby airports at both your origin and destination can sometimes uncover more economical flight options. While it may add to your ground travel time, the savings on airfare can sometimes be significant. Always factor in the additional transportation costs and time when considering this.

Related routes

Consider alternative routes from Medellín

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Cheap Flights from Medellín to Panama City

Today’s best flight deals from Medellín to Panama City

Unlock all 500+ flight deals to Panama City and get alerts when great deals appear

Route Intelligence — 486,190 Searches this Week

Insights for flights from Medellín to Panama City

How much is a round trip from Medellín to Panama City

The cheapest time to fly from Medellín to Panama City

Direct flights from Medellín to Panama City

Last-minute flights going from Medellín to Panama City

Biggest price drops on these dates for flights from Medellín to Panama City

Popular Airports to fly from Medellín to Panama City

Medellín - Panama City route insights

Recent fares are above the typical level.

Fly in November for the best prices.

Connecting flights take 22h 16m on average.

No direct flights available for this route.

United Airlines offers a current deal.

Deals appear frequently for this route.

Medellín main airports to depart from

Panama City main airports to arrive at

Airports nearby Panama City used as alternative

Business & First Class Flight Deals to Panama City

Best Elite deals to Panama City

Jul 12

Jul 07

Jul 12

Sep 19

Aug 18

Jul 13

Jul 07

Jul 13

Jul 07

Aug 18

Aug 18

Aug 18

Jul 12

Jul 13

Aug 06

Frequently Asked Questions About Flights to Panama City

How can I find cheap flights from Medellín to Panama City?

How can I find cheap flights from Medellín to Panama City?

When should I book flights from Medellín to Panama City?

When should I book flights from Medellín to Panama City?

Should I compare nearby airports for flights from Medellín to Panama City?

Should I compare nearby airports for flights from Medellín to Panama City?

Are direct flights from Medellín to Panama City always the best option?

Are direct flights from Medellín to Panama City always the best option?

Can flexible travel dates help on Medellín to Panama City flights?

Can flexible travel dates help on Medellín to Panama City flights?

What extra costs should I check before booking Medellín to Panama City flights?

What extra costs should I check before booking Medellín to Panama City flights?

Related routes

Consider alternative routes from Medellín