Cheap Flights from Medellín to Santo Domingo
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Prices updated 24 days ago
486,190 searches this week
171 airlines compared
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Fares are subject to change and may not be available for all dates. (Data last updated May 29, 2026.)
Today’s best flight deals from Medellín to Santo Domingo
Explore current cheapest deals departing from Medellín to Santo Domingo
Round trip
Sort by: Cheapest
September 22 - September 29
MDE - Santo Domingo
$217
$265
Round trip
September 19 - September 22
MDE - Santo Domingo
$225
$274
Round trip
October 17 - October 20
MDE - Santo Domingo
$259
$274
Round trip
November 17 - November 21
MDE - Santo Domingo
$226
$274
Round trip
November 17 - November 24
MDE - Santo Domingo
$221
$274
Round trip
August 28 - August 31
MDE - Santo Domingo
$250
$275
Round trip
November 11 - November 21
MDE - Santo Domingo
$216
$282
Round trip
October 10 - October 20
MDE - Santo Domingo
$238
$282
Round trip
September 5 - September 26
MDE - Santo Domingo
$188
$285
Round trip
July 2 - July 6
MDE - Santo Domingo
$245
$286
Round trip
Unlock all 500+ flight deals to Santo Domingo and get alerts when great deals appear
Route Intelligence — 486,190 Searches this Week
Insights for flights from Medellín to Santo Domingo
How much is a round trip from Medellín to Santo Domingo
Regular price: $182 - $334
Prices for flights from Medellín to Santo Domingo are currently within the regular range.
The regular price range for this route is between 182 USD and 334 USD. The lowest deal is 265 USD with Maersk Air, for travel from Sep 22 to Sep 29.
now $265
Low $182
High $334
The cheapest time to fly from Medellín to Santo Domingo
The cheapest month to fly from MDE to SDQ is March, with a median price of $238. The most expensive month is September, with a median price of $310. Prices are generally lower from March to October.
March
Flights from $238
September
Flights from $310
Direct flights from Medellín to Santo Domingo
Maersk Air
Last-minute flights going from Medellín to Santo Domingo
Sat, Jun 20
MDE - Santo Domingo
Medellín (MDE) - Santo Domingo (SDQ)
Copa Airlines
$426
$352
One-way
Wed, Jun 24
MDE - Santo Domingo
Medellín (MDE) - Santo Domingo (SDQ)
Copa Airlines
$458
$315
One-way
Wed, Jun 24
MDE - Santo Domingo
Medellín (MDE) - Santo Domingo (SDQ)
Copa Airlines
$425
$327
One-way
Wed, Jun 24
MDE - Santo Domingo
Medellín (MDE) - Santo Domingo (SDQ)
Copa Airlines
$419
$328
One-way
Thu, Jun 25
MDE - Santo Domingo
Medellín (MDE) - Santo Domingo (SDQ)
Copa Airlines
$402
$327
One-way
Thu, Jun 25
MDE - Santo Domingo
Medellín (MDE) - Santo Domingo (SDQ)
Copa Airlines
$427
$328
One-way
Biggest price drops on these dates for flights from Medellín to Santo Domingo
Jun 24 - Jun 27
$458 → $315
31%
Jun 26 - Jun 30
$418 → $315
25%
Jun 25 - Jun 29
$427 → $328
23%
Jun 24 - Jun 29
$425 → $327
23%
Popular Airports to fly from Medellín to Santo Domingo
Medellín - Santo Domingo route insights
💸 Price insights
Recent fares are above the typical level
Recent fares from Medellín to Santo Domingo are above the typical level, with 5% good prices.
📅 Best time to fly
March is the cheapest month to fly
Historically, March is the cheapest month to fly, with median prices around $238.
⏱️ Flight duration
Direct flights take 5h 26m
The median flight time from Medellín to Santo Domingo is 5h 26m.
✈️ Airlines & availability
Connecting flights are dominant
About 31.1% of deals are for direct flights. Connecting flights typically have 1 stopover.
🏆 Airline highlight
Maersk Air offers direct flights
Maersk Air is one airline that offers direct flights from Medellín to Santo Domingo.
🎯 Booking tip
Deals appear frequently
Deals for flights from Medellín to Santo Domingo appear frequently, about 1 per day.
Medellín main airports to depart from
José María Córdova International (MDE)
José María Córdova International Airport is a good option for flights from Medellín to Santo Domingo.
📍 ~20 km from Medellín city center (reachable by car).
💸 Flights from ~$265
Olaya Herrera (EOH)
Olaya Herrera Airport is an alternative for flights from Medellín to Santo Domingo.
📍 ~5 km from Medellín city center (reachable by car).
💸 Flights from ~$412
Santo Domingo main airports to arrive at
Las Américas International (SDQ)
Las Américas International Airport is a convenient arrival option for flights from Medellín to Santo Domingo.
📍 ~28 km from Santo Domingo (reachable by car)
💸 Flights from ~$265
La Isabela International (JBQ)
La Isabela International Airport offers an alternative arrival point for your trip to Santo Domingo.
📍 ~10 km from Santo Domingo (reachable by car)
💸 Flights from ~$764
Airports nearby Santo Domingo used as alternative
Punta Cana International (PUJ)
Punta Cana International (PUJ) is a major international hub, often offering competitive pricing and direct routes.
📍 ~150 km from Santo Domingo (reachable by car)
💸 Flights from ~$272
Cibao International (STI)
Cibao International (STI) is a reliable alternative for regional and North American travel with frequent flights.
📍 ~155 km from Santo Domingo (reachable by car)
💸 Flights from ~$332
Gregorio Luperón International (POP)
Gregorio Luperón International (POP) is a major international airport serving the north coast with established routes.
📍 ~200 km from Santo Domingo (reachable by car)
💸 Flights from ~$450
Samaná El Catey International (AZS)
Samaná El Catey International (AZS) is geographically the closest alternative, with easy access via a toll road.
📍 ~90 km from Santo Domingo (reachable by car)
💸 Flights from ~$1843
Business & First Class Flight Deals to Santo Domingo
Discover luxury on the budget with premium cabin class on flights from Medellín to Santo Domingo.
Elite
Best Elite deals to Santo Domingo
Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.
From MDE
Elite
Aug 19
Santo Domingo, Dominican Republic
79% AI deal score
$1,221
$765
Save $456
From MDE
Elite
Jul 16
Santo Domingo, Dominican Republic
79% AI deal score
$1,310
$765
Save $545
From MDE
Elite
Sep 03
Santo Domingo, Dominican Republic
79% AI deal score
$1,275
$773
Save $502
From MDE
Elite
Oct 27
Santo Domingo, Dominican Republic
79% AI deal score
$1,306
$795
Save $511
From MDE
Elite
Jun 25
Santo Domingo, Dominican Republic
78% AI deal score
$1,205
$765
Save $440
From MDE
Elite
Nov 09
Santo Domingo, Dominican Republic
78% AI deal score
$1,234
$785
Save $449
From MDE
Elite
Oct 27
Santo Domingo, Dominican Republic
78% AI deal score
$1,265
$790
Save $475
From MDE
Elite
Oct 28
Santo Domingo, Dominican Republic
78% AI deal score
$1,265
$790
Save $475
From MDE
Elite
Oct 31
Santo Domingo, Dominican Republic
78% AI deal score
$1,273
$790
Save $483
From MDE
Elite
Oct 17
Santo Domingo, Dominican Republic
78% AI deal score
$1,260
$790
Save $470
From MDE
Elite
Oct 13
Santo Domingo, Dominican Republic
78% AI deal score
$1,252
$790
Save $462
From MDE
Elite
Oct 15
Santo Domingo, Dominican Republic
78% AI deal score
$1,252
$790
Save $462
From MDE
Elite
Oct 21
Santo Domingo, Dominican Republic
78% AI deal score
$1,251
$790
Save $461
From MDE
Elite
Oct 14
Santo Domingo, Dominican Republic
78% AI deal score
$1,252
$790
Save $462
From MDE
Elite
Oct 22
Santo Domingo, Dominican Republic
78% AI deal score
$1,252
$790
Save $462
From MDE
Elite
Oct 12
Santo Domingo, Dominican Republic
78% AI deal score
$1,255
$790
Save $465
From MDE
Elite
Oct 26
Santo Domingo, Dominican Republic
78% AI deal score
$1,263
$795
Save $468
From MDE
Elite
Oct 27
Santo Domingo, Dominican Republic
78% AI deal score
$1,248
$795
Save $453
From MDE
Elite
Oct 31
Santo Domingo, Dominican Republic
78% AI deal score
$1,248
$795
Save $453
From MDE
Elite
Oct 28
Santo Domingo, Dominican Republic
78% AI deal score
$1,248
$795
Save $453
From MDE
Elite
Nov 05
Santo Domingo, Dominican Republic
77% AI deal score
$1,192
$790
Save $402
From MDE
Elite
Nov 03
Santo Domingo, Dominican Republic
77% AI deal score
$1,189
$790
Save $399
From MDE
Elite
Nov 07
Santo Domingo, Dominican Republic
77% AI deal score
$1,209
$795
Save $414
From MDE
Elite
Nov 10
Santo Domingo, Dominican Republic
77% AI deal score
$1,179
$795
Save $384
From MDE
Elite
Nov 03
Santo Domingo, Dominican Republic
77% AI deal score
$1,180
$795
Save $385
From MDE
Elite
Nov 17
Santo Domingo, Dominican Republic
77% AI deal score
$1,181
$795
Save $386
From MDE
Elite
Nov 12
Santo Domingo, Dominican Republic
77% AI deal score
$1,178
$795
Save $383
From MDE
Elite
Nov 05
Santo Domingo, Dominican Republic
77% AI deal score
$1,177
$795
Save $382
From MDE
Elite
Nov 05
Santo Domingo, Dominican Republic
77% AI deal score
$1,180
$795
Save $385
From MDE
Elite
Nov 19
Santo Domingo, Dominican Republic
77% AI deal score
$1,175
$795
Save $380
From MDE
Elite
Nov 17
Santo Domingo, Dominican Republic
77% AI deal score
$1,178
$795
Save $383
From MDE
Elite
Nov 24
Santo Domingo, Dominican Republic
77% AI deal score
$1,197
$795
Save $402
From MDE
Elite
Nov 12
Santo Domingo, Dominican Republic
77% AI deal score
$1,178
$795
Save $383
From MDE
Elite
Nov 10
Santo Domingo, Dominican Republic
77% AI deal score
$1,178
$795
Save $383
From MDE
Elite
Nov 03
Santo Domingo, Dominican Republic
77% AI deal score
$1,180
$795
Save $385
From MDE
Elite
Nov 19
Santo Domingo, Dominican Republic
77% AI deal score
$1,178
$795
Save $383
From MDE
Elite
Jul 29
Santo Domingo, Dominican Republic
77% AI deal score
$1,234
$804
Save $430
From MDE
Elite
Jul 28
Santo Domingo, Dominican Republic
77% AI deal score
$1,233
$804
Save $429
From MDE
Elite
Jul 14
Santo Domingo, Dominican Republic
77% AI deal score
$1,204
$804
Save $400
From MDE
Elite
Jul 16
Santo Domingo, Dominican Republic
76% AI deal score
$1,203
$804
Save $399
From MDE
Elite
Aug 05
Santo Domingo, Dominican Republic
76% AI deal score
$1,145
$804
Save $341
From MDE
Elite
Aug 06
Santo Domingo, Dominican Republic
76% AI deal score
$1,147
$804
Save $343
From MDE
Elite
Jul 21
Santo Domingo, Dominican Republic
76% AI deal score
$1,204
$804
Save $400
From MDE
Elite
Nov 03
Santo Domingo, Dominican Republic
75% AI deal score
$1,192
$850
Save $342
From MDE
Elite
Nov 03
Santo Domingo, Dominican Republic
75% AI deal score
$1,180
$850
Save $330
From MDE
Elite
Aug 16
Santo Domingo, Dominican Republic
68% AI deal score
$1,870
$1,528
Save $342
From MDE
Elite
Aug 22
Santo Domingo, Dominican Republic
68% AI deal score
$1,847
$1,541
Save $306
From MDE
Elite
Aug 20
Santo Domingo, Dominican Republic
67% AI deal score
$1,825
$1,541
Save $284
From MDE
Elite
Aug 23
Santo Domingo, Dominican Republic
67% AI deal score
$1,830
$1,541
Save $289
From MDE
Elite
Aug 19
Santo Domingo, Dominican Republic
67% AI deal score
$1,825
$1,541
Save $284
From MDE
Elite
Aug 16
Santo Domingo, Dominican Republic
67% AI deal score
$1,832
$1,541
Save $291
From MDE
Elite
Aug 18
Santo Domingo, Dominican Republic
67% AI deal score
$1,825
$1,541
Save $284
From MDE
Elite
Aug 17
Santo Domingo, Dominican Republic
67% AI deal score
$1,808
$1,541
Save $267
From MDE
Elite
Aug 24
Santo Domingo, Dominican Republic
67% AI deal score
$1,830
$1,550
Save $280