Are direct flights from Cartagena to Santiago de Chile always the best option?

Direct flights are often the most convenient option, saving you time and avoiding layovers. However, flights with one or more stops can sometimes be significantly cheaper. Weigh the trade-off between travel time, convenience, and cost when making your decision.

Can flexible travel dates help on Cartagena to Santiago de Chile flights?

Yes, being flexible with your travel dates can often lead to finding more affordable flights. Prices can vary greatly even within the same week or month. Flying on weekdays or during off-peak seasons may result in lower fares.

What extra costs should I check before booking Cartagena to Santiago de Chile flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. These additional fees can impact the total cost of your trip.

Flights From Cartagena

To Santiago de Chile

Cheap Flights from Cartagena to Santiago de Chile

Browse current best options from Cartagena. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

Cartagena

RatePunk searches hundreds of travel sites at once for deals on flights to Santiago de Chile

Prices updated 4 days ago

476 airlines compared

80%+ AI score for best value

Fares are subject to change and may not be available for all dates. (Data last updated Oct 12, 2026.)

Today’s best flight deals from Cartagena to Santiago de Chile

Explore current cheapest deals departing from Cartagena to Santiago de Chile

2026-11-06 – 2026-11-16
CTG - Santiago de Chile
73% AI deal score
$359
$391
Round trip
2026-11-06 – 2026-11-22
CTG - Santiago de Chile
72% AI deal score
$345
$392
Round trip
2027-02-08 – 2027-02-23
CTG - Santiago de Chile
72% AI deal score
$335
$392
Round trip
2027-02-08 – 2027-02-25
CTG - Santiago de Chile
72% AI deal score
$336
$396
Round trip
2026-10-28 – 2026-11-16
CTG - Santiago de Chile
72% AI deal score
$353
$396
Round trip
2026-11-11 – 2026-11-16
CTG - Santiago de Chile
73% AI deal score
$385
$399
Round trip
2026-10-23 – 2026-11-16
CTG - Santiago de Chile
72% AI deal score
$352
$401
Round trip
2026-11-13 – 2026-11-16
CTG - Santiago de Chile
73% AI deal score
$391
$401
Round trip
2026-11-18 – 2026-11-22
CTG - Santiago de Chile
73% AI deal score
$390
$401
Round trip
2026-11-12 – 2026-11-16
CTG - Santiago de Chile
73% AI deal score
$391
$401
Round trip

Cartagena to Santiago de Chile: Overview

Insights for flights from Cartagena to Santiago de Chile

For cheap flights from Cartagena to Santiago de Chile, fares typically range from $589–$758, with a median of $643. Right now, current fares are above the typical level for this route. This indicates that finding a good price may require flexibility or waiting for new deals to emerge.

When is the cheapest time to fly from Cartagena to Santiago de Chile? The most affordable month to fly is typically February, with a median fare of $324. Other cost-effective options include September, where the median fare is $413, and August, with a median of $445. Planning your trip during these months could lead to significant savings.

A typical journey from Cartagena to Santiago de Chile takes approximately 5h 30m. However, this route is primarily served by connecting flights. Most itineraries connect at least once, with the median connecting journey taking 12h 14m and typically involving 2 stopovers. This means you should account for longer travel times when planning your trip.

The route from Cartagena to Santiago de Chile covers a distance of 4900 kilometers, classifying it as a long-haul flight. This distance often means that itineraries will include at least one connection, contributing to the overall journey time. Given that deals are infrequent for this route, setting up a price alert could be beneficial to catch favorable prices as they appear.

How much is a round trip from Cartagena to Santiago de Chile

Regular price: $328 - $561

Prices for flights from Cartagena to Santiago de Chile are currently within the regular range.

The regular price range for this route is between 328 USD and 561 USD. The current lowest deal is 392 USD with B&H Airlines, for travel from Mar 16-Mar 23.

now $392

Low $328

High $561

The cheapest time to fly from Cartagena to Santiago de Chile

The cheapest month to fly from Cartagena to Santiago is February, with a median price of $324. The most expensive month is December, with a median price of $682. Prices are generally lower from February to September.

February

Cheapest

Flights from $324

December

Most Expensive

Flights from $682

Feb

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Cartagena to Santiago de Chile

Avianca

Last-minute flights going from Cartagena to Santiago de Chile

Mon, Oct 19

⌛ Last-Minute

CTG - Santiago de Chile

Cartagena (CTG) - Santiago de Chile (SCL)

B&H Airlines

$381

$464

One-way

Wed, Oct 21

⌛ Last-Minute

CTG - Santiago de Chile

Cartagena (CTG) - Santiago de Chile (SCL)

B&H Airlines

$399

$521

One-way

Wed, Oct 28

⌛ Last-Minute

CTG - Santiago de Chile

Cartagena (CTG) - Santiago de Chile (SCL)

B&H Airlines

$428

$439

One-way

Wed, Oct 28

⌛ Last-Minute

CTG - Santiago de Chile

Cartagena (CTG) - Santiago de Chile (SCL)

B&H Airlines

$353

$457

One-way

Thu, Oct 29

⌛ Last-Minute

CTG - Santiago de Chile

Cartagena (CTG) - Santiago de Chile (SCL)

B&H Airlines

$423

$454

One-way

Sun, Nov 1

⌛ Last-Minute

CTG - Santiago de Chile

Cartagena (CTG) - Santiago de Chile (SCL)

B&H Airlines

$346

$460

One-way

Biggest price drops on these dates for flights from Cartagena to Santiago de Chile

2 nights

Nov 19 - Nov 21

$390 → $345

11%

3 nights

Nov 19 - Nov 22

$390 → $349

11%

5 nights

Nov 19 - Nov 24

$383 → $345

10%

3 nights

Oct 23 - Oct 26

$428 → $401

Popular Airports to fly from Cartagena to Santiago de Chile

Cartagena - Santiago de Chile route insights

💸 Price insights

Recent fares are above the typical level.

Recent fares from Cartagena to Santiago de Chile are above the typical level.

📅 Best time to fly

Fly in February for prices below $324.

Historically, February offers the lowest median prices at $324 for this route.

⏱️ Flight duration

Direct flights take 5h 30m.

The median direct flight from Cartagena to Santiago de Chile takes 5h 30m.

✈️ Airlines & availability

Connecting flights are dominant.

Connecting flights make up 80% of recent fares, with a median of 2 stopovers.

🏆 Airline highlight

Avianca offers direct flights.

Avianca is one airline offering direct flights from Cartagena to Santiago de Chile.

🎯 Booking tip

Deals are rare on this route.

Deals for flights from Cartagena to Santiago de Chile are historically rare.

Cartagena main airports to depart from

Rafael Núñez International (CTG)

Cheapest

Rafael Núñez International Airport (CTG) is a convenient option for flights from Cartagena to Santiago de Chile.

📍 ~7 km from city center (reachable by car)

💸 Flights from ~$346

Santiago de Chile main airports to arrive at

Comodoro Arturo Merino Benítez International (SCL)

Cheapest

SCL is the primary airport for Santiago de Chile, offering convenient access to the city.

📍 ~12 km from city center (reachable by car)

💸 Flights from ~$437

Airports nearby Santiago de Chile used as alternative

Governor Francisco Gabrielli International (MDZ)

Consider this major international airport for connections to Chile, despite requiring an international border crossing.

📍 ~180 km from Santiago de Chile (reachable by car)

💸 Flights from ~$500

Business & First Class Flight Deals to Santiago de Chile

Discover luxury on the budget with premium cabin class on flights from Cartagena to Santiago de Chile.

Elite

Best Elite deals to Santiago de Chile

Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.

From CTG

Elite

Nov 05

Santiago de Chile, Chile

94% AI deal score

$2,592

$1,329

Save $1,263

Avianca, +1

Business Class

From CTG

Elite

Nov 19

Santiago de Chile, Chile

94% AI deal score

$2,511

$1,329

Save $1,182

Avianca, +1

Business Class

From CTG

Elite

Nov 25

Santiago de Chile, Chile

94% AI deal score

$2,550

$1,330

Save $1,220

Avianca, +1

Business Class

From CTG

Elite

Nov 25

Santiago de Chile, Chile

94% AI deal score

$2,550

$1,330

Save $1,220

Avianca, +1

Business Class

From CTG

Elite

Nov 25

Santiago de Chile, Chile

94% AI deal score

$2,550

$1,340

Save $1,210

Avianca, +1

Business Class

From CTG

Elite

Oct 27

Santiago de Chile, Chile

94% AI deal score

$2,815

$1,426

Save $1,389

Avianca, +1

Business Class

From CTG

Elite

Oct 30

Santiago de Chile, Chile

94% AI deal score

$1,586

$857

Save $729

LATAM Chile

Business Class

From CTG

Elite

Nov 09

Santiago de Chile, Chile

94% AI deal score

$1,659

$881

Save $778

LATAM Chile

Business Class

From CTG

Elite

Nov 01

Santiago de Chile, Chile

94% AI deal score

$1,656

$894

Save $762

LATAM Chile

Business Class

From CTG

Elite

Nov 03

Santiago de Chile, Chile

93% AI deal score

$2,578

$1,367

Save $1,211

Avianca, +1

Business Class

From CTG

Elite

Nov 22

Santiago de Chile, Chile

93% AI deal score

$2,529

$1,396

Save $1,133

Copa Airlines

Business Class

From CTG

Elite

Nov 22

Santiago de Chile, Chile

93% AI deal score

$2,529

$1,396

Save $1,133

Copa Airlines

Business Class

Frequently Asked Questions About Flights to Santiago de Chile

To find more affordable flights, consider being flexible with your travel dates and times. Comparing prices across different airlines and booking platforms can often reveal better deals. Setting up price alerts may also help you catch drops in fares.

Booking in advance, often several months before your intended travel date, can sometimes lead to lower prices. However, last-minute deals can occasionally appear, so it's useful to monitor prices. Mid-week bookings may also offer slight savings compared to weekend purchases.

Comparing nearby airports at both your origin and destination can sometimes uncover alternative flight options or better prices. While it may add to travel time, the potential savings could be significant. Always factor in the cost and convenience of ground transportation to and from these alternative airports.

Related routes

More routes from Cartagena

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Flights to Santiago de Chile from other cities

Cartagena to Santiago de Chile: Overview

Insights for flights from Cartagena to Santiago de Chile

How much is a round trip from Cartagena to Santiago de Chile

Regular price: $328 - $561

Prices for flights from Cartagena to Santiago de Chile are currently within the regular range.

The regular price range for this route is between 328 USD and 561 USD. The current lowest deal is 392 USD with B&H Airlines, for travel from Mar 16-Mar 23.

now $392

Low $328

High $561

The cheapest time to fly from Cartagena to Santiago de Chile

February

Cheapest

Flights from $324

December

Most Expensive

Flights from $682

Feb

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Cartagena to Santiago de Chile

Avianca

Last-minute flights going from Cartagena to Santiago de Chile

Mon, Oct 19

⌛ Last-Minute

CTG - Santiago de Chile

Cartagena (CTG) - Santiago de Chile (SCL)

B&H Airlines

$381

$464

One-way

Wed, Oct 21

⌛ Last-Minute

CTG - Santiago de Chile

Cartagena (CTG) - Santiago de Chile (SCL)

B&H Airlines

$399

$521

One-way

Wed, Oct 28

⌛ Last-Minute

CTG - Santiago de Chile

Cartagena (CTG) - Santiago de Chile (SCL)

B&H Airlines

$428

$439

One-way

Wed, Oct 28

⌛ Last-Minute

CTG - Santiago de Chile

Cartagena (CTG) - Santiago de Chile (SCL)

B&H Airlines

$353

$457

One-way

Thu, Oct 29

⌛ Last-Minute

CTG - Santiago de Chile

Cartagena (CTG) - Santiago de Chile (SCL)

B&H Airlines

$423

$454

One-way

Sun, Nov 1

⌛ Last-Minute

CTG - Santiago de Chile

Cartagena (CTG) - Santiago de Chile (SCL)

B&H Airlines

$346

$460

One-way

Biggest price drops on these dates for flights from Cartagena to Santiago de Chile

2 nights

Nov 19 - Nov 21

$390 → $345

11%

3 nights

Nov 19 - Nov 22

$390 → $349

11%

5 nights

Nov 19 - Nov 24

$383 → $345

10%

3 nights

Oct 23 - Oct 26

$428 → $401

Popular Airports to fly from Cartagena to Santiago de Chile

Cartagena - Santiago de Chile route insights

💸 Price insights

Recent fares are above the typical level.

Recent fares from Cartagena to Santiago de Chile are above the typical level.

📅 Best time to fly

Fly in February for prices below $324.

Historically, February offers the lowest median prices at $324 for this route.

⏱️ Flight duration

Direct flights take 5h 30m.

The median direct flight from Cartagena to Santiago de Chile takes 5h 30m.

✈️ Airlines & availability

Connecting flights are dominant.

Connecting flights make up 80% of recent fares, with a median of 2 stopovers.

🏆 Airline highlight

Avianca offers direct flights.

Avianca is one airline offering direct flights from Cartagena to Santiago de Chile.

🎯 Booking tip

Deals are rare on this route.

Deals for flights from Cartagena to Santiago de Chile are historically rare.

Cartagena main airports to depart from

Rafael Núñez International (CTG)

Cheapest

Rafael Núñez International Airport (CTG) is a convenient option for flights from Cartagena to Santiago de Chile.

📍 ~7 km from city center (reachable by car)

💸 Flights from ~$346

Santiago de Chile main airports to arrive at

Comodoro Arturo Merino Benítez International (SCL)

Cheapest

SCL is the primary airport for Santiago de Chile, offering convenient access to the city.

📍 ~12 km from city center (reachable by car)

💸 Flights from ~$437

Airports nearby Santiago de Chile used as alternative

Governor Francisco Gabrielli International (MDZ)

Consider this major international airport for connections to Chile, despite requiring an international border crossing.

Santiago de Chile, Chile

93% AI deal score

$2,529

$1,396

Save $1,133

Copa Airlines

Business Class

Frequently Asked Questions About Flights to Santiago de Chile

Cheap Flights from Cartagena to Santiago de Chile

Today’s best flight deals from Cartagena to Santiago de Chile

Cartagena to Santiago de Chile: Overview

Insights for flights from Cartagena to Santiago de Chile

How much is a round trip from Cartagena to Santiago de Chile

The cheapest time to fly from Cartagena to Santiago de Chile

Direct flights from Cartagena to Santiago de Chile

Last-minute flights going from Cartagena to Santiago de Chile

Biggest price drops on these dates for flights from Cartagena to Santiago de Chile

Popular Airports to fly from Cartagena to Santiago de Chile

Cartagena - Santiago de Chile route insights

Recent fares are above the typical level.

Fly in February for prices below $324.

Direct flights take 5h 30m.

Connecting flights are dominant.

Avianca offers direct flights.

Deals are rare on this route.

Cartagena main airports to depart from

Santiago de Chile main airports to arrive at

Airports nearby Santiago de Chile used as alternative

Business & First Class Flight Deals to Santiago de Chile

Best Elite deals to Santiago de Chile

Nov 05

Nov 19

Nov 25

Nov 25

Nov 25

Oct 27

Oct 30

Nov 09

Nov 01

Nov 03

Nov 22

Nov 22

Frequently Asked Questions About Flights to Santiago de Chile

How can I find cheap flights from Cartagena to Santiago de Chile?

When should I book flights from Cartagena to Santiago de Chile?

Should I compare nearby airports for flights from Cartagena to Santiago de Chile?

Are direct flights from Cartagena to Santiago de Chile always the best option?

Can flexible travel dates help on Cartagena to Santiago de Chile flights?

What extra costs should I check before booking Cartagena to Santiago de Chile flights?

Related routes

More routes from Cartagena

Flights to Santiago de Chile from other cities

Cartagena to Santiago de Chile: Overview

Insights for flights from Cartagena to Santiago de Chile

How much is a round trip from Cartagena to Santiago de Chile

The cheapest time to fly from Cartagena to Santiago de Chile

Direct flights from Cartagena to Santiago de Chile

Last-minute flights going from Cartagena to Santiago de Chile

Biggest price drops on these dates for flights from Cartagena to Santiago de Chile

Popular Airports to fly from Cartagena to Santiago de Chile

Cartagena - Santiago de Chile route insights

Recent fares are above the typical level.

Fly in February for prices below $324.

Direct flights take 5h 30m.

Connecting flights are dominant.

Avianca offers direct flights.

Deals are rare on this route.

Cartagena main airports to depart from

Santiago de Chile main airports to arrive at

Airports nearby Santiago de Chile used as alternative

Business & First Class Flight Deals to Santiago de Chile

Best Elite deals to Santiago de Chile

Nov 05

Nov 19

Nov 25

Nov 25

Nov 25

Oct 27

Oct 30

Nov 09

Nov 01

Nov 03

Nov 22

Nov 22

Frequently Asked Questions About Flights to Santiago de Chile

How can I find cheap flights from Cartagena to Santiago de Chile?

When should I book flights from Cartagena to Santiago de Chile?

Should I compare nearby airports for flights from Cartagena to Santiago de Chile?