Are direct flights from Panama City to Rome always the best option?

Direct flights offer convenience and save travel time, but they are not always the most economical choice. Flights with one or more layovers can often be significantly cheaper. Consider your budget and time constraints when deciding between direct and connecting flights.

Can flexible travel dates help on Panama City to Rome flights?

Yes, being flexible with your travel dates can often lead to finding cheaper flights. Prices for airfare can vary greatly depending on the day of the week or time of year. Adjusting your departure or return by a few days may reveal more budget-friendly options.

What extra costs should I check before booking Panama City to Rome flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. Factor these into your total travel budget to avoid surprises.

Flights From Panama City

To Rome

Cheap Flights from Panama City to Rome

Browse current best options from Panama City. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

Panama City

RatePunk searches hundreds of travel sites at once for deals on flights to Rome

Prices updated today

462 airlines compared

80%+ AI score for best value

Fares are subject to change and may not be available for all dates. (Data last updated Sep 15, 2026.)

Today’s best flight deals from Panama City to Rome

Explore current cheapest deals departing from Panama City to Rome

2027-03-16 – 2027-03-23
ECP - Rome
89% AI deal score
$972
$627
Round trip
2027-01-11 – 2027-01-18
ECP - Rome
86% AI deal score
$882
$664
Round trip
2026-10-05 – 2026-10-14
ECP - Rome
85% AI deal score
$863
$699
Round trip
2027-03-15 – 2027-03-22
ECP - Rome
85% AI deal score
$921
$699
Round trip
2026-11-16 – 2026-11-23
ECP - Rome
77% AI deal score
$731
$717
Round trip
2026-11-26 – 2026-12-03
ECP - Rome
77% AI deal score
$730
$717
Round trip
2027-01-26 – 2027-02-03
ECP - Rome
83% AI deal score
$881
$722
Round trip
2026-11-08 – 2026-11-17
ECP - Rome
76% AI deal score
$709
$726
Round trip
2026-11-14 – 2026-11-21
ECP - Rome
77% AI deal score
$729
$730
Round trip
2027-01-21 – 2027-01-26
ECP - Rome
83% AI deal score
$894
$731
Round trip

Panama City to Rome: Overview

Insights for flights from Panama City to Rome

For those seeking cheap flights from Panama City to Rome, fares typically range from $818–$1419, with a median of $1013. Right now, fares are below the typical level, and about 13% of recent fares were classified as a good price. New deals appear almost daily, offering frequent opportunities to find favorable prices.

When is the cheapest time to fly from Panama City to Rome? The most affordable month to fly is January, with a median fare of $401. Following closely, July also offers competitive pricing with a median of $489. November is another relatively inexpensive option, showing a median fare of $677.

Most itineraries for flights from Panama City to Rome connect at least once, as 0% of recent fares were non-stop. For connecting itineraries, the typical number of connections is 2.

A typical journey from Panama City to Rome takes about 33h 35m, including connections. This is a long-haul route, covering a substantial distance of 8418 km.

How much is a round trip from Panama City to Rome

Regular price: $608 - $935

Prices for flights from Panama City to Rome are currently within the regular range.

Regular prices for this route typically range from $608 to $935. The current lowest deal is $667 with Deutsche Luft Hansa, for travel from Nov 16-Nov 23.

now $667

Low $608

High $935

The cheapest time to fly from Panama City to Rome

The cheapest month to fly from ECP to ROM is January, with a median price of $401. The most expensive month is September, with a median price of $1033. Prices are generally lower from January to December.

January

Cheapest

Flights from $401

September

Most Expensive

Flights from $1,033

Jan

Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Panama City to Rome

United Airlines

Air France

Deutsche Luft Hansa

KLM

Last-minute flights going from Panama City to Rome

Mon, Sep 21

⌛ Last-Minute

ECP - Rome

Panama City (ECP) - Rome (FCO)

United Airlines

$893

$785

One-way

Tue, Sep 22

⌛ Last-Minute

ECP - Rome

Panama City (ECP) - Rome (FCO)

$867

$775

One-way

Tue, Sep 22

⌛ Last-Minute

ECP - Rome

Panama City (ECP) - Rome (FCO)

$865

$826

One-way

Wed, Sep 23

⌛ Last-Minute

ECP - Rome

Panama City (ECP) - Rome (FCO)

$873

$786

One-way

Wed, Sep 23

⌛ Last-Minute

ECP - Rome

Panama City (ECP) - Rome (FCO)

$878

$831

One-way

Thu, Sep 24

⌛ Last-Minute

ECP - Rome

Panama City (ECP) - Rome (FCO)

United Airlines

$879

$814

One-way

Biggest price drops on these dates for flights from Panama City to Rome

7 nights

Mar 16 - Mar 23

$972 → $627

36%

7 nights

Mar 15 - Mar 22

$921 → $699

24%

7 nights

Jan 11 - Jan 18

$882 → $672

24%

9 nights

Oct 5 - Oct 14

$863 → $699

19%

Popular Airports to fly from Panama City to Rome

Panama City - Rome route insights

💸 Price insights

Recent fares are below the typical level

Recent fares from Panama City to Rome are below the typical level at $667.

📅 Best time to fly

January offers the lowest median price

Historically, January has offered the lowest median price at $401 for flights to Rome.

⏱️ Flight duration

Flights typically take 33h 35m

Flights from Panama City to Rome typically take 33h 35m, with two stopovers.

✈️ Airlines & availability

Connecting flights are dominant

Connecting flights are dominant on this route, with no direct flights available.

🏆 Airline highlight

Deutsche Luft Hansa offers a deal at $667

Deutsche Luft Hansa has a deal from Panama City to Rome for $667 via skyscanner.

🎯 Booking tip

Deals are frequent on this route

Deals on flights from Panama City to Rome are frequent, appearing within a 30-day window.

Panama City main airports to depart from

Northwest Florida Beaches International (ECP)

Cheapest

Northwest Florida Beaches International Airport (ECP) is a convenient option for flights from Panama City to Rome.

📍 ~26 km from Panama City (reachable by car)

💸 Flights from ~$734

Rome main airports to arrive at

Leonardo da Vinci–Fiumicino Airport (FCO)

Cheapest

Leonardo da Vinci–Fiumicino Airport is a convenient arrival choice for flights from Panama City to Rome.

📍 ~24 km from Rome city center (reachable by car, bus, or train).

💸 Flights from ~$715

Airports nearby Rome used as alternative

Naples International (NAP)

Naples International is a major international hub with significant capacity, offering excellent high-speed rail connectivity to Rome.

📍 ~187 km from Rome (reachable by high-speed rail)

💸 Flights from ~$870

Business & First Class Flight Deals to Rome

Discover luxury on the budget with premium cabin class on flights from Panama City to Rome.

Elite

Best Elite deals to Rome

Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.

From ECP

Elite

Dec 21

Rome, Italy

93% AI deal score

$8,582

$3,497

Save $5,085

United Airlines

Business Class

From ECP

Elite

Nov 16

Rome, Italy

91% AI deal score

$2,594

$1,812

Save $782

United Airlines

Business Class

From ECP

Elite

Dec 20

Rome, Italy

76% AI deal score

$3,024

Scandinavian Airlines

Business Class

From ECP

Elite

Dec 21

Rome, Italy

74% AI deal score

$4,627

KLM

Business Class

From ECP

Elite

Oct 22

Rome, Italy

72% AI deal score

$4,586

WestJet, +1

Business Class

From ECP

Elite

Oct 22

Rome, Italy

72% AI deal score

$4,627

WestJet, +1

Business Class

From ECP

Elite

Oct 22

Rome, Italy

72% AI deal score

$4,969

WestJet, +1

Business Class

From ECP

Elite

Oct 25

Rome, Italy

71% AI deal score

$5,634

WestJet, +1

Business Class

From ECP

Elite

Oct 25

Rome, Italy

71% AI deal score

$5,676

WestJet, +1

Business Class

From ECP

Elite

Dec 20

Rome, Italy

71% AI deal score

$5,749

United Airlines

Business Class

From ECP

Elite

Oct 04

Rome, Italy

71% AI deal score

$5,787

United Airlines

Business Class

From ECP

Elite

Oct 25

Rome, Italy

71% AI deal score

$6,017

WestJet, +1

Business Class

Frequently Asked Questions About Flights to Rome

To find more affordable flights, consider being flexible with your travel dates and times. Using flight comparison sites can help you see various options across different airlines. Looking into flights with layovers may also present lower prices than direct routes.

Booking flights in advance often provides better prices, though the ideal booking window can vary. Generally, purchasing tickets several weeks or months before your departure date may help you secure more favorable fares. Prices can fluctuate, so monitoring them is useful.

Comparing nearby airports at both your origin and destination can sometimes lead to more affordable flight options. While it may add to your ground travel time, the potential savings on airfare can be significant. Always check transportation costs and times to these alternative airports.

Related routes

More routes from Panama City

Flights from Panama City to Amsterdam Flights from Panama City to Athens Flights from Panama City to Bangkok Flights from Panama City to Barcelona Flights from Panama City to Bocas Town, Bocas del Toro Flights from Panama City to Copenhagen Flights from Panama City to Dubai Flights from Panama City to Dublin Flights from Panama City to Tokyo Flights from Panama City to Venice Flights from Panama City to Vienna Flights from Panama City to Zürich

Flights to Rome from other cities

Flights from Bergerac to Rome Flights from Edinburgh to Rome Flights from Eindhoven to Rome Flights from El Paso to Rome Flights from Erie to Rome Flights from Eugene to Rome Flights from Exeter to Rome Flights from Faro to Rome Flights from Fort-de-France to Rome Flights from Fresno to Rome Flights from Karlsruhe to Rome Flights from Vail to Rome

Panama City to Rome: Overview

Insights for flights from Panama City to Rome

Most itineraries for flights from Panama City to Rome connect at least once, as 0% of recent fares were non-stop. For connecting itineraries, the typical number of connections is 2.

A typical journey from Panama City to Rome takes about 33h 35m, including connections. This is a long-haul route, covering a substantial distance of 8418 km.

How much is a round trip from Panama City to Rome

Regular price: $608 - $935

Prices for flights from Panama City to Rome are currently within the regular range.

Regular prices for this route typically range from $608 to $935. The current lowest deal is $667 with Deutsche Luft Hansa, for travel from Nov 16-Nov 23.

now $667

Low $608

High $935

The cheapest time to fly from Panama City to Rome

January

Cheapest

Flights from $401

September

Most Expensive

Flights from $1,033

Jan

Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Panama City to Rome

United Airlines

Air France

Deutsche Luft Hansa

KLM

Last-minute flights going from Panama City to Rome

Mon, Sep 21

⌛ Last-Minute

ECP - Rome

Panama City (ECP) - Rome (FCO)

United Airlines

$893

$785

One-way

Tue, Sep 22

⌛ Last-Minute

ECP - Rome

Panama City (ECP) - Rome (FCO)

$867

$775

One-way

Tue, Sep 22

⌛ Last-Minute

ECP - Rome

Panama City (ECP) - Rome (FCO)

$865

$826

One-way

Wed, Sep 23

⌛ Last-Minute

ECP - Rome

Panama City (ECP) - Rome (FCO)

$873

$786

One-way

Wed, Sep 23

⌛ Last-Minute

ECP - Rome

Panama City (ECP) - Rome (FCO)

$878

$831

One-way

Thu, Sep 24

⌛ Last-Minute

ECP - Rome

Panama City (ECP) - Rome (FCO)

United Airlines

$879

$814

One-way

Biggest price drops on these dates for flights from Panama City to Rome

7 nights

Mar 16 - Mar 23

$972 → $627

36%

7 nights

Mar 15 - Mar 22

$921 → $699

24%

7 nights

Jan 11 - Jan 18

$882 → $672

24%

9 nights

Oct 5 - Oct 14

$863 → $699

19%

Popular Airports to fly from Panama City to Rome

Panama City - Rome route insights

💸 Price insights

Recent fares are below the typical level

Recent fares from Panama City to Rome are below the typical level at $667.

📅 Best time to fly

January offers the lowest median price

Historically, January has offered the lowest median price at $401 for flights to Rome.

⏱️ Flight duration

Flights typically take 33h 35m

Flights from Panama City to Rome typically take 33h 35m, with two stopovers.

✈️ Airlines & availability

Connecting flights are dominant

Connecting flights are dominant on this route, with no direct flights available.

🏆 Airline highlight

Deutsche Luft Hansa offers a deal at $667

Deutsche Luft Hansa has a deal from Panama City to Rome for $667 via skyscanner.

🎯 Booking tip

Deals are frequent on this route

Deals on flights from Panama City to Rome are frequent, appearing within a 30-day window.

Panama City main airports to depart from

Northwest Florida Beaches International (ECP)

Cheapest

Northwest Florida Beaches International Airport (ECP) is a convenient option for flights from Panama City to Rome.

📍 ~26 km from Panama City (reachable by car)

💸 Flights from ~$734

Rome main airports to arrive at

Leonardo da Vinci–Fiumicino Airport (FCO)

Cheapest

Leonardo da Vinci–Fiumicino Airport is a convenient arrival choice for flights from Panama City to Rome.

📍 ~24 km from Rome city center (reachable by car, bus, or train).

💸 Flights from ~$715

Airports nearby Rome used as alternative

Naples International (NAP)

Naples International is a major international hub with significant capacity, offering excellent high-speed rail connectivity to Rome.

📍 ~187 km from Rome (reachable by high-speed rail)

💸 Flights from ~$870

Business & First Class Flight Deals to Rome

Discover luxury on the budget with premium cabin class on flights from Panama City to Rome.

Elite

Best Elite deals to Rome

Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.

From ECP

Elite

Dec 21

Rome, Italy

93% AI deal score

$8,582

$3,497

Save $5,085

United Airlines

Business Class

From ECP

Elite

Nov 16

Rome, Italy

91% AI deal score

$2,594

$1,812

Save $782

United Airlines

Business Class

From ECP

Elite

Dec 20

Rome, Italy

76% AI deal score

$3,024

Scandinavian Airlines

Business Class

From ECP

Elite

Dec 21

Rome, Italy

74% AI deal score

$4,627

KLM

Business Class

From ECP

Elite

Oct 22

Rome, Italy

72% AI deal score

$4,586

WestJet, +1

Business Class

From ECP

Elite

Oct 22

Rome, Italy

72% AI deal score

$4,627

WestJet, +1

Business Class

From ECP

Elite

Oct 22

Rome, Italy

72% AI deal score

$4,969

WestJet, +1

Business Class

From ECP

Elite

Oct 25

Rome, Italy

71% AI deal score

$5,634

WestJet, +1

Business Class

From ECP

Elite

Oct 25

Rome, Italy

71% AI deal score

$5,676

WestJet, +1

Business Class

From ECP

Elite

Dec 20

Rome, Italy

71% AI deal score

$5,749

United Airlines

Business Class

From ECP

Elite

Oct 04

Rome, Italy

71% AI deal score

$5,787

United Airlines

Business Class

From ECP

Elite

Oct 25

Rome, Italy

71% AI deal score

$6,017

WestJet, +1

Business Class

Frequently Asked Questions About Flights to Rome

Cheap Flights from Panama City to Rome

Today’s best flight deals from Panama City to Rome

Panama City to Rome: Overview

Insights for flights from Panama City to Rome

How much is a round trip from Panama City to Rome

The cheapest time to fly from Panama City to Rome

Direct flights from Panama City to Rome

Last-minute flights going from Panama City to Rome

Biggest price drops on these dates for flights from Panama City to Rome

Popular Airports to fly from Panama City to Rome

Panama City - Rome route insights

Recent fares are below the typical level

January offers the lowest median price

Flights typically take 33h 35m

Connecting flights are dominant

Deutsche Luft Hansa offers a deal at $667

Deals are frequent on this route

Panama City main airports to depart from

Rome main airports to arrive at

Airports nearby Rome used as alternative

Business & First Class Flight Deals to Rome

Best Elite deals to Rome

Dec 21

Nov 16

Dec 20

Dec 21

Oct 22

Oct 22

Oct 22

Oct 25

Oct 25

Dec 20

Oct 04

Oct 25

Frequently Asked Questions About Flights to Rome

How can I find cheap flights from Panama City to Rome?

When should I book flights from Panama City to Rome?

Should I compare nearby airports for flights from Panama City to Rome?

Are direct flights from Panama City to Rome always the best option?

Can flexible travel dates help on Panama City to Rome flights?

What extra costs should I check before booking Panama City to Rome flights?

Related routes

More routes from Panama City

Flights to Rome from other cities

Panama City to Rome: Overview

Insights for flights from Panama City to Rome

How much is a round trip from Panama City to Rome

The cheapest time to fly from Panama City to Rome

Direct flights from Panama City to Rome

Last-minute flights going from Panama City to Rome

Biggest price drops on these dates for flights from Panama City to Rome

Popular Airports to fly from Panama City to Rome

Panama City - Rome route insights

Recent fares are below the typical level

January offers the lowest median price

Flights typically take 33h 35m

Connecting flights are dominant

Deutsche Luft Hansa offers a deal at $667

Deals are frequent on this route

Panama City main airports to depart from

Rome main airports to arrive at

Airports nearby Rome used as alternative

Business & First Class Flight Deals to Rome

Best Elite deals to Rome

Dec 21

Nov 16

Dec 20

Dec 21

Oct 22

Oct 22

Oct 22

Oct 25

Oct 25

Dec 20

Oct 04

Oct 25

Frequently Asked Questions About Flights to Rome

How can I find cheap flights from Panama City to Rome?

When should I book flights from Panama City to Rome?

Should I compare nearby airports for flights from Panama City to Rome?