Are direct flights from Greenville to San Francisco always the best option?

Direct flights offer convenience and save time, but they are not always the most budget-friendly choice. Flights with layovers can sometimes be significantly cheaper, especially if you are flexible with your travel itinerary. Consider your priorities for cost versus travel time.

Can flexible travel dates help on Greenville to San Francisco flights?

Yes, being flexible with your travel dates can often lead to finding more affordable flights. Prices can vary greatly depending on the day of the week or season. Shifting your travel by a few days may result in noticeable savings on your ticket.

What extra costs should I check before booking Greenville to San Francisco flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. Being aware of these additional fees can help you calculate the total cost of your trip.

Flights From Greenville

To San Francisco

Cheap Flights from Greenville to San Francisco

Browse current best options from Greenville. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

Greenville

RatePunk searches hundreds of travel sites at once for deals on flights to San Francisco

Prices updated 1 day ago

461 airlines compared

80%+ AI score for best value

Fares are subject to change and may not be available for all dates. (Data last updated Sep 14, 2026.)

Today’s best flight deals from Greenville to San Francisco

Explore current cheapest deals departing from Greenville to San Francisco

2026-10-14 – 2026-10-17
GSP - San Francisco
80% AI deal score
$425
$333
Round trip
2026-10-15 – 2026-10-19
GSP - San Francisco
80% AI deal score
$425
$334
Round trip
2026-10-14 – 2026-10-19
GSP - San Francisco
79% AI deal score
$416
$334
Round trip
2026-10-15 – 2026-10-20
GSP - San Francisco
79% AI deal score
$416
$334
Round trip
2026-10-05 – 2026-10-07
GSP - San Francisco
80% AI deal score
$432
$334
Round trip
2026-12-15 – 2026-12-29
GSP - San Francisco
77% AI deal score
$383
$334
Round trip
2027-02-05 – 2027-02-08
GSP - San Francisco
78% AI deal score
$411
$348
Round trip
2026-11-09 – 2026-11-12
GSP - San Francisco
71% AI deal score
$353
$351
Round trip
2026-11-02 – 2026-11-12
GSP - San Francisco
70% AI deal score
$311
$356
Round trip
2026-10-06 – 2026-10-12
GSP - San Francisco
76% AI deal score
$402
$361
Round trip

Greenville to San Francisco: Overview

Insights for flights from Greenville to San Francisco

Most itineraries for cheap flights from Greenville to San Francisco connect at least once, with 0% of recent fares being non-stop. When connections are necessary, the typical number of stopovers is 2.

Right now, fares to San Francisco from Greenville are above the typical level. Prices for this route typically range from $469 to $952, with a median of $571. Currently, 0% of recent fares are classified as a good price.

When is the cheapest time to fly from Greenville to San Francisco? The most affordable month to fly is typically February, with a median fare of $234. Other cost-effective months include December, with a median of $310, and January, where the median fare is $343.

A typical journey from Greenville to San Francisco takes approximately 17h 4m, including connections. This route covers a distance of 3587 kilometers, classifying it as a medium-haul flight. New deals for this route appear almost daily, suggesting frequent opportunities to find favorable prices.

How much is a round trip from Greenville to San Francisco

Regular price: $347 - $618

Prices for flights from Greenville to San Francisco are currently below the regular range.

The regular price range for this route is between $347 and $618. The current lowest deal is $335 with American Airlines for travel from Oct 14-Oct 17.

now $335

Low $347

High $618

The cheapest time to fly from Greenville to San Francisco

The cheapest month to fly from GSP to SFO is February, with a median price of $234. The most expensive month is July, with a median price of $873. Prices are generally lower from January to December.

February

Cheapest

Flights from $234

July

Most Expensive

Flights from $873

Jan

Feb

Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Greenville to San Francisco

Breeze Airways

Frontier Airlines

United Airlines

American Airlines

Last-minute flights going from Greenville to San Francisco

Wed, Sep 16

⌛ Last-Minute

GSP - San Francisco

Greenville (GSP) - San Francisco (SFO)

Breeze Airways

$638

$1,006

One-way

Thu, Sep 17

⌛ Last-Minute

GSP - San Francisco

Greenville (GSP) - San Francisco (SFO)

Breeze Airways

$607

$632

One-way

Wed, Sep 23

⌛ Last-Minute

GSP - San Francisco

Greenville (GSP) - San Francisco (SFO)

Breeze Airways

$478

$515

One-way

Thu, Sep 24

⌛ Last-Minute

GSP - San Francisco

Greenville (GSP) - San Francisco (SFO)

Allegiant Air

$462

$433

One-way

Thu, Sep 24

⌛ Last-Minute

GSP - San Francisco

Greenville (GSP) - San Francisco (SFO)

Allegiant Air

$465

$594

One-way

Fri, Sep 25

⌛ Last-Minute

GSP - San Francisco

Greenville (GSP) - San Francisco (SFO)

Allegiant Air

$458

$453

One-way

Biggest price drops on these dates for flights from Greenville to San Francisco

2 nights

Oct 5 - Oct 7

$432 → $334

23%

3 nights

Oct 14 - Oct 17

$425 → $333

22%

4 nights

Oct 15 - Oct 19

$425 → $334

21%

5 nights

Oct 14 - Oct 19

$416 → $334

20%

Popular Airports to fly from Greenville to San Francisco

Greenville - San Francisco route insights

💸 Price insights

Recent fares are below the typical level at $335.

Recent fares from Greenville to San Francisco are below the typical level for this route.

📅 Best time to fly

Fly in February for prices as low as $234.

Historically, February, December, and January offer the lowest median prices for this route.

⏱️ Flight duration

Connecting flights average 17h 4m.

Flights from Greenville to San Francisco typically involve 2 stopovers, with a median duration of 17h 4m.

✈️ Airlines & availability

Connecting flights are dominant for this route.

There are no direct flights; connecting flights are dominant, with frequent deals available.

🏆 Airline highlight

American Airlines has a recent deal for $335.

A recent deal with American Airlines for $335 is available for October 14-October 17.

🎯 Booking tip

Deals are frequent for Greenville to San Francisco.

Deals for flights from Greenville to San Francisco are frequent, appearing often over 30 days.

Greenville main airports to depart from

Greenville–Spartanburg International (GSP)

Cheapest

Greenville–Spartanburg International is a convenient option for flights from Greenville to San Francisco.

📍 ~17 km from Greenville (reachable by car)

💸 Flights from ~$335

San Francisco main airports to arrive at

San Francisco International (SFO)

Cheapest

San Francisco International Airport is a good choice for reaching San Francisco and the wider Bay Area.

📍 ~18 km from city center (reachable by car)

💸 Flights from ~$335

Airports nearby San Francisco used as alternative

Oakland International (OAK)

Oakland International is a useful alternative with an extensive domestic network and direct BART rail connection.

📍 ~16 km from destination city (reachable by car or train)

💸 Flights from ~$417

Business & First Class Flight Deals to San Francisco

Discover luxury on the budget with premium cabin class on flights from Greenville to San Francisco.

Elite

Best Elite deals to San Francisco

Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.

From GSP

Elite

Oct 30

San Francisco, United States

90% AI deal score

$1,938

$1,158

Save $780

United Airlines

Business Class

From GSP

Elite

Oct 24

San Francisco, United States

89% AI deal score

$1,636

$1,115

Save $521

United Airlines

Business Class

From GSP

Elite

Dec 24

San Francisco, United States

88% AI deal score

$1,726

$1,180

Save $546

United Airlines

Business Class

From GSP

Elite

Feb 16

San Francisco, United States

87% AI deal score

$1,464

$1,115

Save $349

United Airlines

Business Class

From GSP

Elite

Feb 17

San Francisco, United States

87% AI deal score

$1,464

$1,115

Save $349

United Airlines

Business Class

From GSP

Elite

Nov 25

San Francisco, United States

87% AI deal score

$1,687

$1,201

Save $486

United Airlines

Business Class

From GSP

Elite

Nov 02

San Francisco, United States

86% AI deal score

$1,560

$1,209

Save $351

United Airlines

Business Class

From GSP

Elite

Dec 30

San Francisco, United States

86% AI deal score

$1,730

$1,291

Save $439

United Airlines

Business Class

From GSP

Elite

Feb 27

San Francisco, United States

85% AI deal score

$1,479

$1,201

Save $278

United Airlines

Business Class

From GSP

Elite

Oct 03

San Francisco, United States

85% AI deal score

$1,615

$1,271

Save $344

United Airlines

Business Class

From GSP

Elite

Sep 29

San Francisco, United States

85% AI deal score

$1,652

$1,271

Save $381

United Airlines

Business Class

From GSP

Elite

Nov 16

San Francisco, United States

85% AI deal score

$1,648

$1,273

Save $375

United Airlines

Business Class

Frequently Asked Questions About Flights to San Francisco

To find more affordable flights, consider being flexible with your travel dates and times. Using flight comparison sites can help you compare various options efficiently. Looking into different airlines and booking in advance may also uncover better deals.

Booking flights in advance often provides more competitive prices, especially for popular routes. However, prices can fluctuate, so monitoring fares over time may help you identify a good booking window. Weekday bookings can sometimes be more affordable than weekend bookings.

Comparing nearby airports can sometimes reveal more affordable flight options or different schedules. While it might add to your ground travel time, the potential savings could be significant. Always factor in the cost and convenience of transportation to and from alternative airports.

Related routes

More routes from Greenville

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Flights to San Francisco from other cities

Flights from Hong Kong to San Francisco Flights from Honolulu to San Francisco Flights from Houston to San Francisco Flights from Huntsville to San Francisco Flights from Hyderabad to San Francisco Flights from Indianapolis to San Francisco Flights from Islamabad to San Francisco Flights from Istanbul to San Francisco Flights from Kathmandu to San Francisco Flights from Kuala Lumpur to San Francisco Flights from Las Vegas to San Francisco Flights from Los Angeles to San Francisco

Greenville to San Francisco: Overview

Insights for flights from Greenville to San Francisco

How much is a round trip from Greenville to San Francisco

Regular price: $347 - $618

Prices for flights from Greenville to San Francisco are currently below the regular range.

The regular price range for this route is between $347 and $618. The current lowest deal is $335 with American Airlines for travel from Oct 14-Oct 17.

now $335

Low $347

High $618

The cheapest time to fly from Greenville to San Francisco

The cheapest month to fly from GSP to SFO is February, with a median price of $234. The most expensive month is July, with a median price of $873. Prices are generally lower from January to December.

February

Cheapest

Flights from $234

July

Most Expensive

Flights from $873

Jan

Feb

Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Greenville to San Francisco

Breeze Airways

Frontier Airlines

United Airlines

American Airlines

Last-minute flights going from Greenville to San Francisco

Wed, Sep 16

⌛ Last-Minute

GSP - San Francisco

Greenville (GSP) - San Francisco (SFO)

Breeze Airways

$638

$1,006

One-way

Thu, Sep 17

⌛ Last-Minute

GSP - San Francisco

Greenville (GSP) - San Francisco (SFO)

Breeze Airways

$607

$632

One-way

Wed, Sep 23

⌛ Last-Minute

GSP - San Francisco

Greenville (GSP) - San Francisco (SFO)

Breeze Airways

$478

$515

One-way

Thu, Sep 24

⌛ Last-Minute

GSP - San Francisco

Greenville (GSP) - San Francisco (SFO)

Allegiant Air

$462

$433

One-way

Thu, Sep 24

⌛ Last-Minute

GSP - San Francisco

Greenville (GSP) - San Francisco (SFO)

Allegiant Air

$465

$594

One-way

Fri, Sep 25

⌛ Last-Minute

GSP - San Francisco

Greenville (GSP) - San Francisco (SFO)

Allegiant Air

$458

$453

One-way

Biggest price drops on these dates for flights from Greenville to San Francisco

2 nights

Oct 5 - Oct 7

$432 → $334

23%

3 nights

Oct 14 - Oct 17

$425 → $333

22%

4 nights

Oct 15 - Oct 19

$425 → $334

21%

5 nights

Oct 14 - Oct 19

$416 → $334

20%

Popular Airports to fly from Greenville to San Francisco

Greenville - San Francisco route insights

💸 Price insights

Recent fares are below the typical level at $335.

Recent fares from Greenville to San Francisco are below the typical level for this route.

📅 Best time to fly

Fly in February for prices as low as $234.

Historically, February, December, and January offer the lowest median prices for this route.

⏱️ Flight duration

Connecting flights average 17h 4m.

Flights from Greenville to San Francisco typically involve 2 stopovers, with a median duration of 17h 4m.

✈️ Airlines & availability

Connecting flights are dominant for this route.

There are no direct flights; connecting flights are dominant, with frequent deals available.

🏆 Airline highlight

American Airlines has a recent deal for $335.

A recent deal with American Airlines for $335 is available for October 14-October 17.

🎯 Booking tip

Deals are frequent for Greenville to San Francisco.

Deals for flights from Greenville to San Francisco are frequent, appearing often over 30 days.

Greenville main airports to depart from

Greenville–Spartanburg International (GSP)

Cheapest

Greenville–Spartanburg International is a convenient option for flights from Greenville to San Francisco.

📍 ~17 km from Greenville (reachable by car)

💸 Flights from ~$335

San Francisco main airports to arrive at

San Francisco International (SFO)

Cheapest

San Francisco International Airport is a good choice for reaching San Francisco and the wider Bay Area.

📍 ~18 km from city center (reachable by car)

💸 Flights from ~$335

Airports nearby San Francisco used as alternative

Oakland International (OAK)

Oakland International is a useful alternative with an extensive domestic network and direct BART rail connection.

San Francisco, United States

85% AI deal score

$1,648

$1,273

Save $375

United Airlines

Business Class

Frequently Asked Questions About Flights to San Francisco

Cheap Flights from Greenville to San Francisco

Today’s best flight deals from Greenville to San Francisco

Greenville to San Francisco: Overview

Insights for flights from Greenville to San Francisco

How much is a round trip from Greenville to San Francisco

The cheapest time to fly from Greenville to San Francisco

Direct flights from Greenville to San Francisco

Last-minute flights going from Greenville to San Francisco

Biggest price drops on these dates for flights from Greenville to San Francisco

Popular Airports to fly from Greenville to San Francisco

Greenville - San Francisco route insights

Recent fares are below the typical level at $335.

Fly in February for prices as low as $234.

Connecting flights average 17h 4m.

Connecting flights are dominant for this route.

American Airlines has a recent deal for $335.

Deals are frequent for Greenville to San Francisco.

Greenville main airports to depart from

San Francisco main airports to arrive at

Airports nearby San Francisco used as alternative

Business & First Class Flight Deals to San Francisco

Best Elite deals to San Francisco

Oct 30

Oct 24

Dec 24

Feb 16

Feb 17

Nov 25

Nov 02

Dec 30

Feb 27

Oct 03

Sep 29

Nov 16

Frequently Asked Questions About Flights to San Francisco

How can I find cheap flights from Greenville to San Francisco?

When should I book flights from Greenville to San Francisco?

Should I compare nearby airports for flights from Greenville to San Francisco?

Are direct flights from Greenville to San Francisco always the best option?

Can flexible travel dates help on Greenville to San Francisco flights?

What extra costs should I check before booking Greenville to San Francisco flights?

Related routes

More routes from Greenville

Flights to San Francisco from other cities

Greenville to San Francisco: Overview

Insights for flights from Greenville to San Francisco

How much is a round trip from Greenville to San Francisco

The cheapest time to fly from Greenville to San Francisco

Direct flights from Greenville to San Francisco

Last-minute flights going from Greenville to San Francisco

Biggest price drops on these dates for flights from Greenville to San Francisco

Popular Airports to fly from Greenville to San Francisco

Greenville - San Francisco route insights

Recent fares are below the typical level at $335.

Fly in February for prices as low as $234.

Connecting flights average 17h 4m.

Connecting flights are dominant for this route.

American Airlines has a recent deal for $335.

Deals are frequent for Greenville to San Francisco.

Greenville main airports to depart from

San Francisco main airports to arrive at

Airports nearby San Francisco used as alternative

Business & First Class Flight Deals to San Francisco

Best Elite deals to San Francisco

Oct 30

Oct 24

Dec 24

Feb 16

Feb 17

Nov 25

Nov 02

Dec 30

Feb 27

Oct 03

Sep 29

Nov 16

Frequently Asked Questions About Flights to San Francisco

How can I find cheap flights from Greenville to San Francisco?

When should I book flights from Greenville to San Francisco?

Should I compare nearby airports for flights from Greenville to San Francisco?