Are direct flights from Medellín to Guayaquil always the best option?

Direct flights offer convenience by reducing travel time and avoiding layovers. However, they are not always the most budget-friendly choice. Flights with connections can often be more economical, depending on your priorities for cost versus travel duration.

Can flexible travel dates help on Medellín to Guayaquil flights?

Yes, being flexible with your travel dates can significantly impact flight prices. Flying on weekdays or during off-peak seasons often results in lower fares. Adjusting your departure or return by a few days may reveal more affordable options.

What extra costs should I check before booking Medellín to Guayaquil flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. Factor these into your total travel budget to avoid surprises.

Flights From Medellín

To Guayaquil

Cheap Flights from Medellín to Guayaquil

Browse current best options from Medellín. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

Medellín

RatePunk searches hundreds of travel sites at once for deals on flights to Guayaquil

Prices updated today

485 airlines compared

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Fares are subject to change and may not be available for all dates. (Data last updated Nov 2, 2026.)

Today’s best flight deals from Medellín to Guayaquil

Explore current cheapest deals departing from Medellín to Guayaquil

2026-12-18 – 2026-12-23
MDE - Guayaquil
39% AI deal score
$170
$384
Round trip
2026-11-13 – 2026-11-16
MDE - Guayaquil
38% AI deal score
$256
$387
Round trip
2026-12-07 – 2026-12-23
MDE - Guayaquil
38% AI deal score
$143
$395
Round trip
2026-12-18 – 2026-12-21
MDE - Guayaquil
39% AI deal score
$173
$396
Round trip
2026-12-02 – 2026-12-07
MDE - Guayaquil
39% AI deal score
$171
$401
Round trip
2026-11-23 – 2026-11-30
MDE - Guayaquil
35% AI deal score
$138
$401
Round trip
2026-11-27 – 2026-11-30
MDE - Guayaquil
34% AI deal score
$144
$402
Round trip
2026-10-30 – 2026-11-04
MDE - Guayaquil
38% AI deal score
$239
$402
Round trip
2026-12-15 – 2026-12-31
MDE - Guayaquil
40% AI deal score
$242
$407
Round trip
2026-11-20 – 2026-11-29
MDE - Guayaquil
37% AI deal score
$226
$408
Round trip

Medellín to Guayaquil: Overview

Insights for flights from Medellín to Guayaquil

Right now, the cheapest fares from Medellín to Guayaquil start at $333, with 7% of recent fares classified as a good price. Fares for this route typically range from $333–$353, with a median of $338. Current prices are significantly below the typical level, indicating a favorable time to consider booking. New deals for this route are infrequent, so setting up a price alert can be beneficial.

When is the cheapest time to fly from Medellín to Guayaquil? The most economical month to fly is January, with a median fare of $203. Following closely, February offers a median fare of $288, and September presents a median of $335, making these months generally more affordable for your trip.

A typical journey from Medellín to Guayaquil takes about 2h 0m. This route is primarily served by direct flights, with 79.7% of recent itineraries being non-stop. For the remaining itineraries that include connections, the median journey time extends to 7h 40m, typically involving 2 stopovers.

The distance between Medellín and Guayaquil is 1050 km, classifying this as a short-haul route. This means you can expect a relatively quick flight, making it a convenient option for regional travel.

How much is a round trip from Medellín to Guayaquil

Regular price: $236 - $307

Prices for flights from Medellín to Guayaquil are currently above the regular range.

The regular price range for this route is between 236 USD and 307 USD. The current lowest deal is 380 USD via skyscanner for travel from Nov 6-Nov 9.

now $380

Low $236

High $307

The cheapest time to fly from Medellín to Guayaquil

The cheapest month to fly from MDE to GYE is January, with a median price of $203. The most expensive month is March, with a median price of $404. Prices are generally lower from January to November.

January

Cheapest

Flights from $203

March

Most Expensive

Flights from $404

Jan

Feb

Mar

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Medellín to Guayaquil

Avianca

Last-minute flights going from Medellín to Guayaquil

Wed, Oct 28

⌛ Last-Minute

MDE - Guayaquil

Medellín (MDE) - Guayaquil (GYE)

Avianca

$181

$459

One-way

Wed, Oct 28

⌛ Last-Minute

MDE - Guayaquil

Medellín (MDE) - Guayaquil (GYE)

Avianca

$184

$459

One-way

Wed, Oct 28

⌛ Last-Minute

MDE - Guayaquil

Medellín (MDE) - Guayaquil (GYE)

Avianca

$188

$459

One-way

Thu, Nov 5

⌛ Last-Minute

MDE - Guayaquil

Medellín (MDE) - Guayaquil (GYE)

Copa Airlines

$269

$397

One-way

Thu, Nov 5

⌛ Last-Minute

MDE - Guayaquil

Medellín (MDE) - Guayaquil (GYE)

Copa Airlines

$293

$397

One-way

Thu, Nov 5

⌛ Last-Minute

MDE - Guayaquil

Medellín (MDE) - Guayaquil (GYE)

Copa Airlines

$251

$436

One-way

Biggest price drops on these dates for flights from Medellín to Guayaquil

7 nights

Oct 28 - Nov 4

$365 → $402

10%

9 nights

Oct 31 - Nov 9

$333 → $405

22%

7 nights

Dec 23 - Dec 30

$280 → $390

39%

10 nights

Nov 1 - Nov 11

$274 → $401

47%

Popular Airports to fly from Medellín to Guayaquil

Medellín - Guayaquil route insights

💸 Price insights

Recent fares are above the typical level.

Recent fares for Medellín to Guayaquil are currently above the typical level.

📅 Best time to fly

Fly in January for the best prices.

Historically, January, February, and September offer the lowest median prices for this route.

⏱️ Flight duration

Direct flights take 2h 0m.

The typical direct flight duration is 2h 0m, while connecting flights average 7h 40m.

✈️ Airlines & availability

79.7% of flights are direct.

Most flights on this route are direct, with connecting flights typically having 2 stopovers.

🏆 Airline highlight

Avianca offers direct flights.

Avianca is one airline that offers direct flights for the Medellín to Guayaquil route.

🎯 Booking tip

Deals are rare for this route.

Deals for flights from Medellín to Guayaquil have historically been rare over the last 30 days.

Medellín main airports to depart from

José María Córdova International (MDE)

Cheapest

José María Córdova International Airport is a convenient departure point for flights from Medellín to Guayaquil.

📍 ~20 km from Medellín (reachable by car)

💸 Flights from ~$387

Olaya Herrera (EOH)

Olaya Herrera Airport offers an alternative departure option for flights from Medellín to Guayaquil.

📍 ~3 km from Medellín (reachable by car)

💸 Flights from ~$583

Guayaquil main airports to arrive at

José Joaquín de Olmedo International (GYE)

Cheapest

José Joaquín de Olmedo International Airport is a great arrival choice for flights from Medellín to Guayaquil.

📍 ~5 km from city center (reachable by car)

💸 Flights from ~$390

Airports nearby Guayaquil used as alternative

Mariscal Sucre International (UIO)

Cheapest

Mariscal Sucre International is the primary international hub for Ecuador, offering the most extensive route network.

📍 ~400 km from Guayaquil (significant road travel time if not flying between cities).

💸 Flights from ~$274

Business & First Class Flight Deals to Guayaquil

Discover luxury on the budget with premium cabin class on flights from Medellín to Guayaquil.

Elite

Best Elite deals to Guayaquil

Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.

From MDE

Elite

Oct 29

Guayaquil, Ecuador

83% AI deal score

$1,368

$680

Save $688

LATAM Chile

Business Class

From MDE

Elite

Oct 29

Guayaquil, Ecuador

81% AI deal score

$1,412

$747

Save $665

LATAM Chile

Business Class

From MDE

Elite

Nov 16

Guayaquil, Ecuador

80% AI deal score

$1,375

$752

Save $623

LATAM Chile

Business Class

From MDE

Elite

Nov 15

Guayaquil, Ecuador

77% AI deal score

$1,370

$839

Save $531

LATAM Chile

Business Class

From MDE

Elite

Oct 29

Guayaquil, Ecuador

77% AI deal score

$1,411

$897

Save $514

LATAM Chile

Business Class

From MDE

Elite

Nov 18

Guayaquil, Ecuador

76% AI deal score

$1,374

$879

Save $495

LATAM Chile

Business Class

From MDE

Elite

Nov 11

Guayaquil, Ecuador

76% AI deal score

$1,368

$880

Save $488

LATAM Chile

Business Class

From MDE

Elite

Oct 29

Guayaquil, Ecuador

76% AI deal score

$1,392

$930

Save $462

LATAM Chile

Business Class

From MDE

Elite

Oct 29

Guayaquil, Ecuador

76% AI deal score

$1,368

$933

Save $435

LATAM Chile

Business Class

From MDE

Elite

Oct 29

Guayaquil, Ecuador

76% AI deal score

$1,418

$947

Save $471

LATAM Chile

Business Class

From MDE

Elite

Nov 05

Guayaquil, Ecuador

75% AI deal score

$1,367

$931

Save $436

LATAM Chile

Business Class

From MDE

Elite

Nov 11

Guayaquil, Ecuador

74% AI deal score

$1,384

$954

Save $430

LATAM Chile

Business Class

Frequently Asked Questions About Flights to Guayaquil

To find more affordable flights, consider being flexible with your travel dates and times. Using flight comparison sites can help you compare options from various providers. Looking into flights with layovers may also present lower prices than direct routes.

Booking flights in advance often helps secure better prices, though the ideal booking window can vary. Prices may fluctuate based on demand and seasonality. Monitoring price trends over time can also be beneficial before making a purchase.

Comparing nearby airports at both your origin and destination can sometimes reveal different flight options or prices. While not always necessary, it may offer more flexibility. This strategy can be useful if your travel plans allow for alternative airport choices.

Related routes

More routes from Medellín

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Flights to Guayaquil from other cities

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Medellín to Guayaquil: Overview

Insights for flights from Medellín to Guayaquil

How much is a round trip from Medellín to Guayaquil

Regular price: $236 - $307

Prices for flights from Medellín to Guayaquil are currently above the regular range.

The regular price range for this route is between 236 USD and 307 USD. The current lowest deal is 380 USD via skyscanner for travel from Nov 6-Nov 9.

now $380

Low $236

High $307

The cheapest time to fly from Medellín to Guayaquil

The cheapest month to fly from MDE to GYE is January, with a median price of $203. The most expensive month is March, with a median price of $404. Prices are generally lower from January to November.

January

Cheapest

Flights from $203

March

Most Expensive

Flights from $404

Jan

Feb

Mar

Jul

Aug

Sep

Oct

Nov

Dec

Direct flights from Medellín to Guayaquil

Avianca

Last-minute flights going from Medellín to Guayaquil

Wed, Oct 28

⌛ Last-Minute

MDE - Guayaquil

Medellín (MDE) - Guayaquil (GYE)

Avianca

$181

$459

One-way

Wed, Oct 28

⌛ Last-Minute

MDE - Guayaquil

Medellín (MDE) - Guayaquil (GYE)

Avianca

$184

$459

One-way

Wed, Oct 28

⌛ Last-Minute

MDE - Guayaquil

Medellín (MDE) - Guayaquil (GYE)

Avianca

$188

$459

One-way

Thu, Nov 5

⌛ Last-Minute

MDE - Guayaquil

Medellín (MDE) - Guayaquil (GYE)

Copa Airlines

$269

$397

One-way

Thu, Nov 5

⌛ Last-Minute

MDE - Guayaquil

Medellín (MDE) - Guayaquil (GYE)

Copa Airlines

$293

$397

One-way

Thu, Nov 5

⌛ Last-Minute

MDE - Guayaquil

Medellín (MDE) - Guayaquil (GYE)

Copa Airlines

$251

$436

One-way

Biggest price drops on these dates for flights from Medellín to Guayaquil

7 nights

Oct 28 - Nov 4

$365 → $402

10%

9 nights

Oct 31 - Nov 9

$333 → $405

22%

7 nights

Dec 23 - Dec 30

$280 → $390

39%

10 nights

Nov 1 - Nov 11

$274 → $401

47%

Popular Airports to fly from Medellín to Guayaquil

Medellín - Guayaquil route insights

💸 Price insights

Recent fares are above the typical level.

Recent fares for Medellín to Guayaquil are currently above the typical level.

📅 Best time to fly

Fly in January for the best prices.

Historically, January, February, and September offer the lowest median prices for this route.

⏱️ Flight duration

Direct flights take 2h 0m.

The typical direct flight duration is 2h 0m, while connecting flights average 7h 40m.

✈️ Airlines & availability

79.7% of flights are direct.

Most flights on this route are direct, with connecting flights typically having 2 stopovers.

🏆 Airline highlight

Avianca offers direct flights.

Avianca is one airline that offers direct flights for the Medellín to Guayaquil route.

🎯 Booking tip

Deals are rare for this route.

Deals for flights from Medellín to Guayaquil have historically been rare over the last 30 days.

Medellín main airports to depart from

José María Córdova International (MDE)

Cheapest

José María Córdova International Airport is a convenient departure point for flights from Medellín to Guayaquil.

📍 ~20 km from Medellín (reachable by car)

💸 Flights from ~$387

Olaya Herrera (EOH)

Olaya Herrera Airport offers an alternative departure option for flights from Medellín to Guayaquil.

📍 ~3 km from Medellín (reachable by car)

💸 Flights from ~$583

Guayaquil main airports to arrive at

José Joaquín de Olmedo International (GYE)

Cheapest

José Joaquín de Olmedo International Airport is a great arrival choice for flights from Medellín to Guayaquil.

📍 ~5 km from city center (reachable by car)

💸 Flights from ~$390

Airports nearby Guayaquil used as alternative

Mariscal Sucre International (UIO)

Cheapest

Mariscal Sucre International is the primary international hub for Ecuador, offering the most extensive route network.

Guayaquil, Ecuador

74% AI deal score

$1,384

$954

Save $430

LATAM Chile

Business Class

Frequently Asked Questions About Flights to Guayaquil

Cheap Flights from Medellín to Guayaquil

Today’s best flight deals from Medellín to Guayaquil

Medellín to Guayaquil: Overview

Insights for flights from Medellín to Guayaquil

How much is a round trip from Medellín to Guayaquil

The cheapest time to fly from Medellín to Guayaquil

Direct flights from Medellín to Guayaquil

Last-minute flights going from Medellín to Guayaquil

Biggest price drops on these dates for flights from Medellín to Guayaquil

Popular Airports to fly from Medellín to Guayaquil

Medellín - Guayaquil route insights

Recent fares are above the typical level.

Fly in January for the best prices.

Direct flights take 2h 0m.

79.7% of flights are direct.

Avianca offers direct flights.

Deals are rare for this route.

Medellín main airports to depart from

Guayaquil main airports to arrive at

Airports nearby Guayaquil used as alternative

Business & First Class Flight Deals to Guayaquil

Best Elite deals to Guayaquil

Oct 29

Oct 29

Nov 16

Nov 15

Oct 29

Nov 18

Nov 11

Oct 29

Oct 29

Oct 29

Nov 05

Nov 11

Frequently Asked Questions About Flights to Guayaquil

How can I find cheap flights from Medellín to Guayaquil?

When should I book flights from Medellín to Guayaquil?

Should I compare nearby airports for flights from Medellín to Guayaquil?

Are direct flights from Medellín to Guayaquil always the best option?

Can flexible travel dates help on Medellín to Guayaquil flights?

What extra costs should I check before booking Medellín to Guayaquil flights?

Related routes

More routes from Medellín

Flights to Guayaquil from other cities

Medellín to Guayaquil: Overview

Insights for flights from Medellín to Guayaquil

How much is a round trip from Medellín to Guayaquil

The cheapest time to fly from Medellín to Guayaquil

Direct flights from Medellín to Guayaquil

Last-minute flights going from Medellín to Guayaquil

Biggest price drops on these dates for flights from Medellín to Guayaquil

Popular Airports to fly from Medellín to Guayaquil

Medellín - Guayaquil route insights

Recent fares are above the typical level.

Fly in January for the best prices.

Direct flights take 2h 0m.

79.7% of flights are direct.

Avianca offers direct flights.

Deals are rare for this route.

Medellín main airports to depart from

Guayaquil main airports to arrive at

Airports nearby Guayaquil used as alternative

Business & First Class Flight Deals to Guayaquil

Best Elite deals to Guayaquil

Oct 29

Oct 29

Nov 16

Nov 15

Oct 29

Nov 18

Nov 11

Oct 29

Oct 29

Oct 29

Nov 05

Nov 11

Frequently Asked Questions About Flights to Guayaquil

How can I find cheap flights from Medellín to Guayaquil?

When should I book flights from Medellín to Guayaquil?

Should I compare nearby airports for flights from Medellín to Guayaquil?