Are direct flights from Rome to Knoxville always the best option?

Direct flights offer convenience and save time, but they are not always the most economical choice. Flights with one or more layovers can often be significantly cheaper, especially for longer distances. Consider your budget and time constraints when deciding between direct and connecting flights.

Can flexible travel dates help on Rome to Knoxville flights?

Yes, being flexible with your travel dates can significantly impact the price of your flight. Flying on weekdays, during off-peak seasons, or avoiding major holidays often results in lower fares. Even shifting your travel by a day or two can sometimes lead to considerable savings.

What extra costs should I check before booking Rome to Knoxville flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. Be aware of currency conversion fees if booking in a different currency.

Flights From Rome

To Knoxville

Cheap Flights from Rome to Knoxville

Browse current best options from Rome. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

Rome

RatePunk searches hundreds of travel sites at once for deals on flights to Knoxville

Prices updated 1 day ago

462 airlines compared

80%+ AI score for best value

Fares are subject to change and may not be available for all dates. (Data last updated Sep 15, 2026.)

Today’s best flight deals from Rome to Knoxville

Explore current cheapest deals departing from Rome to Knoxville

2026-09-24 – 2026-09-28
ROM - Knoxville
93% AI deal score
1,035 €
651 €
Round trip
2026-11-09 – 2026-11-14
ROM - Knoxville
86% AI deal score
851 €
694 €
Round trip
2026-11-09 – 2026-12-03
ROM - Knoxville
79% AI deal score
796 €
700 €
Round trip
2026-11-07 – 2026-11-14
ROM - Knoxville
80% AI deal score
838 €
719 €
Round trip
2026-11-12 – 2026-11-14
ROM - Knoxville
81% AI deal score
873 €
720 €
Round trip
2026-11-19 – 2026-12-03
ROM - Knoxville
78% AI deal score
808 €
725 €
Round trip
2026-11-07 – 2026-12-03
ROM - Knoxville
78% AI deal score
793 €
725 €
Round trip
2026-11-12 – 2026-12-03
ROM - Knoxville
78% AI deal score
797 €
726 €
Round trip
2026-11-12 – 2026-12-10
ROM - Knoxville
78% AI deal score
796 €
733 €
Round trip
2026-09-26 – 2026-09-30
ROM - Knoxville
91% AI deal score
1,017 €
743 €
Round trip

Rome to Knoxville: Overview

Insights for flights from Rome to Knoxville

Right now, if you are looking for cheap flights from Rome to Knoxville, fares are significantly below the typical level. Prices for this route typically range from $978–$1331, with a median of $1056. Currently, about 20% of recent fares are considered a good price for this long-haul journey. New deals for this route are infrequent, so setting up a price alert can be beneficial.

When is the cheapest time to fly from Rome to Knoxville? Based on recent data, the most affordable month to fly is May, with a median fare of $1041. Following closely are April, with a median of $1058, and June, where the median fare is $1062. These months offer the most competitive pricing for this route.

For flights from Rome to Knoxville, most itineraries connect at least once. There are no direct flights from Rome to Knoxville, meaning all journeys will include connections. When connecting, the typical number of stopovers is 2, which impacts the overall travel time.

How long is the flight from Rome to Knoxville? A typical journey, including connections, takes approximately 55h 55m. This duration reflects the fact that all itineraries involve at least one stopover, extending the total travel time significantly.

How much is a round trip from Rome to Knoxville

Regular price: €869 - €1,296

Prices are currently below the regular range.

The regular price range for flights from Rome to Knoxville is 869 EUR to 1296 EUR. The current lowest deal is 651 EUR with Deutsche Luft Hansa for travel from Sep 24-Sep 28.

now 651 €

Low 869 €

High 1,296 €

The cheapest time to fly from Rome to Knoxville

The cheapest month to fly from Rome to Knoxville is May, with a median price of $1041. The most expensive month is June, with a median price of $1062. Prices are generally lower from April to May.

May

Cheapest

Flights from 1,041 €

June

Most Expensive

Flights from 1,062 €

Apr

May

Jun

Direct flights from Rome to Knoxville

Allegiant Air

Aer Lingus

TAP Portugal

Aero Services Executive

Last-minute flights going from Rome to Knoxville

Thu, Sep 17

⌛ Last-Minute

FCO - Knoxville

Rome (FCO) - Knoxville (TYS)

Aer Lingus

1,140 €

2,432 €

One-way

Fri, Sep 25

⌛ Last-Minute

FCO - Knoxville

Rome (FCO) - Knoxville (TYS)

Deutsche Luft Hansa

984 €

743 €

One-way

Sat, Sep 26

⌛ Last-Minute

FCO - Knoxville

Rome (FCO) - Knoxville (TYS)

Lufthansa

1,035 €

741 €

One-way

Thu, Oct 1

⌛ Last-Minute

FCO - Knoxville

Rome (FCO) - Knoxville (TYS)

Deutsche Luft Hansa

1,001 €

654 €

One-way

Thu, Oct 15

⌛ Last-Minute

FCO - Knoxville

Rome (FCO) - Knoxville (TYS)

Alitalia, Allegiant Air

917 €

803 €

One-way

Wed, Oct 21

⌛ Last-Minute

FCO - Knoxville

Rome (FCO) - Knoxville (TYS)

United Airlines

879 €

770 €

One-way

Biggest price drops on these dates for flights from Rome to Knoxville

4 nights

Sep 24 - Sep 28

1,035 € → 658 €

36%

2 nights

Dec 2 - Dec 4

1,019 € → 741 €

27%

2 nights

Dec 9 - Dec 11

1,023 € → 746 €

27%

4 nights

Sep 26 - Sep 30

1,017 € → 743 €

27%

Popular Airports to fly from Rome to Knoxville

Rome - Knoxville route insights

💸 Price insights

Recent fares are below the typical level

Recent fares from Rome to Knoxville are below the typical level for this route.

📅 Best time to fly

May is historically the cheapest month

Historically, May is the cheapest month to fly from Rome to Knoxville, with a median price of $1041.

⏱️ Flight duration

Connecting flights average 55h 55m

Flights from Rome to Knoxville typically involve connections, with an average duration of 55h 55m.

✈️ Airlines & availability

Connecting flights are dominant

Connecting flights are dominant for this route, with no direct flights available in the last 90 days.

🏆 Airline highlight

Deutsche Luft Hansa offers a recent deal

Deutsche Luft Hansa recently offered a deal for $651 from Rome to Knoxville.

🎯 Booking tip

Deals are rare for this route

Deals for flights from Rome to Knoxville are rare, appearing infrequently over the last 30 days.

Rome main airports to depart from

Leonardo da Vinci–Fiumicino Airport (FCO)

Cheapest

Fly from Leonardo da Vinci–Fiumicino Airport for flights from Rome to Knoxville, often with competitive pricing.

📍 ~24 km from Rome city center (reachable by car or train)

💸 Flights from ~€650

Knoxville main airports to arrive at

McGhee Tyson (TYS)

Cheapest

McGhee Tyson Airport (TYS) is a convenient arrival choice for flights from Rome to Knoxville.

📍 ~18 km from Knoxville (reachable by car)

💸 Flights from ~€649

Airports nearby Knoxville used as alternative

Hartsfield–Jackson Atlanta International (ATL)

Cheapest

Hartsfield–Jackson Atlanta International often provides significant cost savings on international and domestic routes.

📍 ~250 km from Knoxville (reachable by car)

💸 Flights from ~€550

Business & First Class Flight Deals to Knoxville

Discover luxury on the budget with premium cabin class on flights from Rome to Knoxville.

Elite

Best Elite deals to Knoxville

Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.

From FCO

Elite

Sep 29

Knoxville, United States

77% AI deal score

$5,502

$5,317

Save $185

United Airlines

Business Class

From FCO

Elite

Oct 15

Knoxville, United States

74% AI deal score

$2,920

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 18

Knoxville, United States

74% AI deal score

$3,061

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 15

Knoxville, United States

74% AI deal score

$3,125

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 21

Knoxville, United States

74% AI deal score

$3,150

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 24

Knoxville, United States

74% AI deal score

$3,150

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 15

Knoxville, United States

73% AI deal score

$2,988

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 18

Knoxville, United States

73% AI deal score

$3,129

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 19

Knoxville, United States

73% AI deal score

$3,205

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 15

Knoxville, United States

73% AI deal score

$3,262

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 18

Knoxville, United States

73% AI deal score

$3,266

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 17

Knoxville, United States

73% AI deal score

$3,267

Condor Flugdienst, +1

Business Class

Frequently Asked Questions About Flights to Knoxville

To find more affordable flights, consider being flexible with your travel dates and times. Comparing prices across different airlines and booking sites can often reveal better deals. Looking into flights with layovers instead of direct routes may also present cheaper options.

Booking flights in advance, often several months out, can sometimes lead to lower prices. However, last-minute deals can also appear, so it's useful to monitor price trends. Mid-week bookings may occasionally offer better rates than weekend purchases.

Yes, comparing nearby airports at both your origin and destination can often lead to discovering more affordable flights. Sometimes, flying into or out of a smaller, less busy airport can result in significant savings. Always factor in the additional travel time and cost to reach these alternative airports.

Rome to Knoxville: Overview

Insights for flights from Rome to Knoxville

How much is a round trip from Rome to Knoxville

Regular price: €869 - €1,296

Prices are currently below the regular range.

The regular price range for flights from Rome to Knoxville is 869 EUR to 1296 EUR. The current lowest deal is 651 EUR with Deutsche Luft Hansa for travel from Sep 24-Sep 28.

now 651 €

Low 869 €

High 1,296 €

The cheapest time to fly from Rome to Knoxville

The cheapest month to fly from Rome to Knoxville is May, with a median price of $1041. The most expensive month is June, with a median price of $1062. Prices are generally lower from April to May.

May

Cheapest

Flights from 1,041 €

June

Most Expensive

Flights from 1,062 €

Apr

May

Jun

Direct flights from Rome to Knoxville

Allegiant Air

Aer Lingus

TAP Portugal

Aero Services Executive

Last-minute flights going from Rome to Knoxville

Thu, Sep 17

⌛ Last-Minute

FCO - Knoxville

Rome (FCO) - Knoxville (TYS)

Aer Lingus

1,140 €

2,432 €

One-way

Fri, Sep 25

⌛ Last-Minute

FCO - Knoxville

Rome (FCO) - Knoxville (TYS)

Deutsche Luft Hansa

984 €

743 €

One-way

Sat, Sep 26

⌛ Last-Minute

FCO - Knoxville

Rome (FCO) - Knoxville (TYS)

Lufthansa

1,035 €

741 €

One-way

Thu, Oct 1

⌛ Last-Minute

FCO - Knoxville

Rome (FCO) - Knoxville (TYS)

Deutsche Luft Hansa

1,001 €

654 €

One-way

Thu, Oct 15

⌛ Last-Minute

FCO - Knoxville

Rome (FCO) - Knoxville (TYS)

Alitalia, Allegiant Air

917 €

803 €

One-way

Wed, Oct 21

⌛ Last-Minute

FCO - Knoxville

Rome (FCO) - Knoxville (TYS)

United Airlines

879 €

770 €

One-way

Biggest price drops on these dates for flights from Rome to Knoxville

4 nights

Sep 24 - Sep 28

1,035 € → 658 €

36%

2 nights

Dec 2 - Dec 4

1,019 € → 741 €

27%

2 nights

Dec 9 - Dec 11

1,023 € → 746 €

27%

4 nights

Sep 26 - Sep 30

1,017 € → 743 €

27%

Popular Airports to fly from Rome to Knoxville

Rome - Knoxville route insights

💸 Price insights

Recent fares are below the typical level

Recent fares from Rome to Knoxville are below the typical level for this route.

📅 Best time to fly

May is historically the cheapest month

Historically, May is the cheapest month to fly from Rome to Knoxville, with a median price of $1041.

⏱️ Flight duration

Connecting flights average 55h 55m

Flights from Rome to Knoxville typically involve connections, with an average duration of 55h 55m.

✈️ Airlines & availability

Connecting flights are dominant

Connecting flights are dominant for this route, with no direct flights available in the last 90 days.

🏆 Airline highlight

Deutsche Luft Hansa offers a recent deal

Deutsche Luft Hansa recently offered a deal for $651 from Rome to Knoxville.

🎯 Booking tip

Deals are rare for this route

Deals for flights from Rome to Knoxville are rare, appearing infrequently over the last 30 days.

Rome main airports to depart from

Leonardo da Vinci–Fiumicino Airport (FCO)

Cheapest

Fly from Leonardo da Vinci–Fiumicino Airport for flights from Rome to Knoxville, often with competitive pricing.

📍 ~24 km from Rome city center (reachable by car or train)

💸 Flights from ~€650

Knoxville main airports to arrive at

McGhee Tyson (TYS)

Cheapest

McGhee Tyson Airport (TYS) is a convenient arrival choice for flights from Rome to Knoxville.

📍 ~18 km from Knoxville (reachable by car)

💸 Flights from ~€649

Airports nearby Knoxville used as alternative

Hartsfield–Jackson Atlanta International (ATL)

Cheapest

Hartsfield–Jackson Atlanta International often provides significant cost savings on international and domestic routes.

📍 ~250 km from Knoxville (reachable by car)

💸 Flights from ~€550

Business & First Class Flight Deals to Knoxville

Discover luxury on the budget with premium cabin class on flights from Rome to Knoxville.

Elite

Best Elite deals to Knoxville

Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.

From FCO

Elite

Sep 29

Knoxville, United States

77% AI deal score

$5,502

$5,317

Save $185

United Airlines

Business Class

From FCO

Elite

Oct 15

Knoxville, United States

74% AI deal score

$2,920

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 18

Knoxville, United States

74% AI deal score

$3,061

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 15

Knoxville, United States

74% AI deal score

$3,125

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 21

Knoxville, United States

74% AI deal score

$3,150

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 24

Knoxville, United States

74% AI deal score

$3,150

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 15

Knoxville, United States

73% AI deal score

$2,988

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 18

Knoxville, United States

73% AI deal score

$3,129

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 19

Knoxville, United States

73% AI deal score

$3,205

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 15

Knoxville, United States

73% AI deal score

$3,262

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 18

Knoxville, United States

73% AI deal score

$3,266

Condor Flugdienst, +1

Business Class

From FCO

Elite

Oct 17

Knoxville, United States

73% AI deal score

$3,267

Condor Flugdienst, +1

Business Class

Frequently Asked Questions About Flights to Knoxville

Cheap Flights from Rome to Knoxville

Today’s best flight deals from Rome to Knoxville

Rome to Knoxville: Overview

Insights for flights from Rome to Knoxville

How much is a round trip from Rome to Knoxville

The cheapest time to fly from Rome to Knoxville

Direct flights from Rome to Knoxville

Last-minute flights going from Rome to Knoxville

Biggest price drops on these dates for flights from Rome to Knoxville

Popular Airports to fly from Rome to Knoxville

Rome - Knoxville route insights

Recent fares are below the typical level

May is historically the cheapest month

Connecting flights average 55h 55m

Connecting flights are dominant

Deutsche Luft Hansa offers a recent deal

Deals are rare for this route

Rome main airports to depart from

Knoxville main airports to arrive at

Airports nearby Knoxville used as alternative

Business & First Class Flight Deals to Knoxville

Best Elite deals to Knoxville

Sep 29

Oct 15

Oct 18

Oct 15

Oct 21

Oct 24

Oct 15

Oct 18

Oct 19

Oct 15

Oct 18

Oct 17

Frequently Asked Questions About Flights to Knoxville

How can I find cheap flights from Rome to Knoxville?

When should I book flights from Rome to Knoxville?

Should I compare nearby airports for flights from Rome to Knoxville?

Are direct flights from Rome to Knoxville always the best option?

Can flexible travel dates help on Rome to Knoxville flights?

What extra costs should I check before booking Rome to Knoxville flights?

Related routes

More routes from Rome

Flights to Knoxville from other cities

Rome to Knoxville: Overview

Insights for flights from Rome to Knoxville

How much is a round trip from Rome to Knoxville

The cheapest time to fly from Rome to Knoxville

Direct flights from Rome to Knoxville

Last-minute flights going from Rome to Knoxville

Biggest price drops on these dates for flights from Rome to Knoxville

Popular Airports to fly from Rome to Knoxville

Rome - Knoxville route insights

Recent fares are below the typical level

May is historically the cheapest month

Connecting flights average 55h 55m

Connecting flights are dominant

Deutsche Luft Hansa offers a recent deal

Deals are rare for this route

Rome main airports to depart from

Knoxville main airports to arrive at

Airports nearby Knoxville used as alternative

Business & First Class Flight Deals to Knoxville

Best Elite deals to Knoxville

Sep 29

Oct 15

Oct 18

Oct 15

Oct 21

Oct 24

Oct 15

Oct 18

Oct 19

Oct 15

Oct 18

Oct 17

Frequently Asked Questions About Flights to Knoxville

How can I find cheap flights from Rome to Knoxville?

When should I book flights from Rome to Knoxville?

Should I compare nearby airports for flights from Rome to Knoxville?