Are direct flights from San Francisco to Knoxville always the best option?

Direct flights offer convenience by minimizing travel time and avoiding layovers. However, connecting flights can sometimes be more economical, depending on the route and airline. Evaluate your priorities for cost versus convenience when making your choice.

Can flexible travel dates help on San Francisco to Knoxville flights?

Yes, being flexible with your travel dates can often lead to finding cheaper flights. Prices can vary significantly between different days of the week or even within the same week. Weekday travel, for example, may sometimes offer lower fares than weekend travel.

What extra costs should I check before booking San Francisco to Knoxville flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. Being aware of these additional fees can help you budget accurately.

Flights From San Francisco

To Knoxville

Cheap Flights from San Francisco to Knoxville

Browse current best options from San Francisco. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

San Francisco

RatePunk searches hundreds of travel sites at once for deals on flights to Knoxville

Prices updated 1 day ago

462 airlines compared

80%+ AI score for best value

Fares are subject to change and may not be available for all dates. (Data last updated Sep 15, 2026.)

Today’s best flight deals from San Francisco to Knoxville

Explore current cheapest deals departing from San Francisco to Knoxville

2026-10-31 – 2026-11-09
SFO - Knoxville
83% AI deal score
$368
$252
Round trip
2026-11-05 – 2026-11-09
SFO - Knoxville
83% AI deal score
$380
$254
Round trip
2026-10-31 – 2026-11-16
SFO - Knoxville
80% AI deal score
$343
$263
Round trip
2026-10-31 – 2026-11-05
SFO - Knoxville
84% AI deal score
$401
$264
Round trip
2026-11-05 – 2026-11-16
SFO - Knoxville
79% AI deal score
$329
$265
Round trip
2026-10-29 – 2026-11-09
SFO - Knoxville
81% AI deal score
$355
$267
Round trip
2027-01-05 – 2027-01-11
SFO - Knoxville
86% AI deal score
$356
$269
Round trip
2026-10-28 – 2026-11-09
SFO - Knoxville
80% AI deal score
$352
$271
Round trip
2026-11-11 – 2026-11-16
SFO - Knoxville
81% AI deal score
$373
$275
Round trip
2026-10-28 – 2026-11-16
SFO - Knoxville
74% AI deal score
$338
$282
Round trip

San Francisco to Knoxville: Overview

Insights for flights from San Francisco to Knoxville

For cheap flights from San Francisco to Knoxville, fares typically range from $656–$1159, with a median of $889. Right now, current fares are below the typical level, and only 1% of recent fares were classified as a good price. New deals show up several times a week, so setting a price alert can help you track changes.

When is the cheapest time to fly from San Francisco to Knoxville? The most affordable month to fly is April, with a median fare of $362. Other cost-effective options include July, with a median fare of $602, and September, where the median fare is $875.

Most itineraries connect at least once when flying from San Francisco to Knoxville, as 0% of recent fares were for non-stop flights. For connecting itineraries, the typical number of connections is 2.

How long is the flight from San Francisco to Knoxville? A typical journey, including connections, takes approximately 74h 33m. This duration reflects the common itineraries that involve at least one stopover.

The route from San Francisco to Knoxville covers a distance of 3405 kilometers, classifying it as a medium-haul journey. This distance generally means a longer travel time, often involving connecting flights.

How much is a round trip from San Francisco to Knoxville

Regular price: $286 - $503

Prices for flights from San Francisco to Knoxville are currently below the regular range.

The regular price range for this route is $286 to $503. The current lowest deal is $257 with Frontier Airlines for travel from Oct 28-Nov 16.

now $257

Low $286

High $503

The cheapest time to fly from San Francisco to Knoxville

The cheapest month to fly from San Francisco to Knoxville is April, with a median price of $397. The most expensive month is August, with a median price of $947. Prices are generally lower from April to September.

April

Cheapest

Flights from $397

August

Most Expensive

Flights from $947

Apr

Jul

Aug

Sep

Direct flights from San Francisco to Knoxville

Frontier Airlines

Allegiant Air

United Airlines

American Airlines

Last-minute flights going from San Francisco to Knoxville

Wed, Sep 16

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

United Airlines

$687

$657

One-way

Thu, Sep 17

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines

$678

$454

One-way

Thu, Sep 17

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines

$560

$475

One-way

Thu, Sep 17

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines

$524

$475

One-way

Thu, Sep 17

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines

$687

$489

One-way

Sat, Sep 19

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

American Airlines

$522

$480

One-way

Biggest price drops on these dates for flights from San Francisco to Knoxville

1 night

Sep 17 - Sep 18

$687 → $487

29%

1 night

Sep 20 - Sep 21

$614 → $497

19%

6 nights

Jan 5 - Jan 11

$356 → $269

25%

7 nights

Sep 17 - Sep 24

$560 → $473

16%

Popular Airports to fly from San Francisco to Knoxville

San Francisco - Knoxville route insights

💸 Price insights

Recent fares are below the typical level

Recent fares from San Francisco to Knoxville are below the typical level at $257.

📅 Best time to fly

April is historically the cheapest month

Historically, April is the cheapest month to fly from San Francisco to Knoxville, with a median price of $362.

⏱️ Flight duration

Connecting flights typically take 74h 33m

Connecting flights from San Francisco to Knoxville typically take 74h 33m.

✈️ Airlines & availability

Connecting flights are dominant

Connecting flights are dominant on this route, with a median of 2 stopovers.

🏆 Airline highlight

Frontier Airlines has 64 deals

Frontier Airlines has 64 deals for flights from San Francisco to Knoxville.

🎯 Booking tip

Deals appear regularly

Deals for flights from San Francisco to Knoxville appear regularly.

San Francisco main airports to depart from

San Francisco International (SFO)

Cheapest

San Francisco International is a convenient option for flights from San Francisco to Knoxville.

📍 ~18 km from city center (reachable by car or train)

💸 Flights from ~$269

Knoxville main airports to arrive at

McGhee Tyson (TYS)

Cheapest

McGhee Tyson Airport is ideal for reaching Knoxville and surrounding areas from San Francisco.

📍 ~18 km from Knoxville (reachable by car)

💸 Flights from ~$277

Airports nearby Knoxville used as alternative

Hartsfield–Jackson Atlanta International (ATL)

Hartsfield–Jackson Atlanta International offers unparalleled direct flight options and often provides significant cost savings.

📍 ~290 km from Knoxville (reachable by car)

💸 Flights from ~$219

Business & First Class Flight Deals to Knoxville

Porter Airlines, +1

Business Class

From SFO

Elite

Oct 20

Knoxville, United States

71% AI deal score

$1,892

Porter Airlines, +1

Business Class

From SFO

Elite

Oct 31

Knoxville, United States

71% AI deal score

$1,941

Porter Airlines, +1

Business Class

From SFO

Elite

Oct 31

Knoxville, United States

71% AI deal score

$1,941

Porter Airlines, +1

Business Class

Frequently Asked Questions About Flights to Knoxville

To find more affordable flights, consider being flexible with your travel dates and times. Comparing prices across different airlines and booking platforms can often reveal better deals. Setting up price alerts may also help you catch drops in fares.

Booking in advance often provides more options and potentially lower prices, especially for popular routes. However, last-minute deals can sometimes appear, so it's wise to monitor fare trends. The ideal booking window can vary depending on demand and seasonality.

Comparing nearby airports can sometimes lead to more affordable flight options or different schedules. While it may require additional ground transportation, the potential savings could be significant. Always factor in the total cost and travel time when considering alternative airports.

Related routes

More routes from San Francisco

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Flights to Knoxville from other cities

Flights from Atlanta to Knoxville Flights from Bangkok to Knoxville Flights from Chicago to Knoxville Flights from Dallas to Knoxville Flights from Florence to Knoxville Flights from Hong Kong to Knoxville Flights from Houston to Knoxville Flights from Madrid to Knoxville Flights from Milan to Knoxville Flights from Nashville to Knoxville Flights from Southampton to Knoxville Flights from Venice to Knoxville

San Francisco to Knoxville: Overview

Insights for flights from San Francisco to Knoxville

How much is a round trip from San Francisco to Knoxville

Regular price: $286 - $503

Prices for flights from San Francisco to Knoxville are currently below the regular range.

The regular price range for this route is $286 to $503. The current lowest deal is $257 with Frontier Airlines for travel from Oct 28-Nov 16.

now $257

Low $286

High $503

The cheapest time to fly from San Francisco to Knoxville

April

Cheapest

Flights from $397

August

Most Expensive

Flights from $947

Apr

Jul

Aug

Sep

Direct flights from San Francisco to Knoxville

Frontier Airlines

Allegiant Air

United Airlines

American Airlines

Last-minute flights going from San Francisco to Knoxville

Wed, Sep 16

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

United Airlines

$687

$657

One-way

Thu, Sep 17

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines

$678

$454

One-way

Thu, Sep 17

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines

$560

$475

One-way

Thu, Sep 17

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines

$524

$475

One-way

Thu, Sep 17

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines

$687

$489

One-way

Sat, Sep 19

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

American Airlines

$522

$480

One-way

Biggest price drops on these dates for flights from San Francisco to Knoxville

1 night

Sep 17 - Sep 18

$687 → $487

29%

1 night

Sep 20 - Sep 21

$614 → $497

19%

6 nights

Jan 5 - Jan 11

$356 → $269

25%

7 nights

Sep 17 - Sep 24

$560 → $473

16%

Popular Airports to fly from San Francisco to Knoxville