Are direct flights from San Francisco to Knoxville always the best option?

Direct flights are often convenient as they save time and reduce the chances of missed connections. However, flights with layovers can sometimes be more budget-friendly. Weigh the importance of convenience against potential cost savings when making your decision.

Can flexible travel dates help on San Francisco to Knoxville flights?

Being flexible with your travel dates can significantly impact the price of your flight. Mid-week travel or flying during off-peak seasons usually offers lower fares than weekend or holiday travel. Even shifting your departure or return by a day or two may result in savings.

What extra costs should I check before booking San Francisco to Knoxville flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. These additional fees can add up and impact your total travel budget.

Flights From San Francisco

To Knoxville

Cheap Flights from San Francisco to Knoxville

Browse current best options from San Francisco. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

San Francisco

RatePunk searches hundreds of travel sites at once for deals on flights to Knoxville

Prices updated 2 days ago

405 airlines compared

80%+ AI score for best value

Fares are subject to change and may not be available for all dates. (Data last updated Jul 26, 2026.)

Today’s best flight deals from San Francisco to Knoxville

Explore current cheapest deals departing from San Francisco to Knoxville

2026-10-28 – 2026-11-02
SFO - Knoxville
86% AI deal score
$419
$248
Round trip
2026-10-29 – 2026-11-02
SFO - Knoxville
86% AI deal score
$426
$250
Round trip
2026-10-28 – 2026-11-16
SFO - Knoxville
83% AI deal score
$366
$256
Round trip
2026-10-28 – 2026-11-09
SFO - Knoxville
83% AI deal score
$377
$256
Round trip
2026-10-31 – 2026-11-02
SFO - Knoxville
86% AI deal score
$428
$256
Round trip
2026-10-29 – 2026-11-16
SFO - Knoxville
83% AI deal score
$370
$258
Round trip
2026-10-29 – 2026-11-09
SFO - Knoxville
83% AI deal score
$381
$258
Round trip
2026-10-28 – 2026-11-01
SFO - Knoxville
85% AI deal score
$423
$263
Round trip
2026-10-29 – 2026-11-15
SFO - Knoxville
82% AI deal score
$370
$265
Round trip
2026-10-29 – 2026-11-12
SFO - Knoxville
81% AI deal score
$379
$276
Round trip

San Francisco to Knoxville: Overview

Insights for flights from San Francisco to Knoxville

A typical journey from San Francisco to Knoxville covers a distance of 3405 kilometers, classifying it as a medium-haul route. For travelers seeking cheap flights from San Francisco to Knoxville, fares right now are significantly below the typical level. Recent fares for this route are typically $656–$1159, with a median of $889. Only 1% of recent fares were classified as a good price, indicating that finding deals can be challenging.

When is the cheapest time to fly from San Francisco to Knoxville? The data indicates that April is the most affordable month, with a median fare of $362. Following April, July offers a median fare of $602, and September presents a median fare of $875. These months offer more competitive pricing compared to the overall median.

Most itineraries for this route connect at least once, as 0% of recent fares were for direct flights from San Francisco to Knoxville. When connecting, the typical number of stopovers is 2, which significantly impacts the overall travel time.

How long is the flight from San Francisco to Knoxville? A typical journey, including connections, is approximately 74h 33m. This extended duration reflects the prevalence of connecting itineraries and the typical number of stopovers involved in reaching Knoxville from San Francisco.

How much is a round trip from San Francisco to Knoxville

Regular price: $344 - $514

Prices for flights from San Francisco to Knoxville are currently below the regular range.

The regular price range for flights from San Francisco to Knoxville is between $344 and $514. The current lowest deal is $249 with Frontier Airlines for travel from Oct 28-Nov 2.

now $249

Low $344

High $514

The cheapest time to fly from San Francisco to Knoxville

The cheapest month to fly from San Francisco to Knoxville is April, with a median price of $397. The most expensive month is August, with a median price of $947. Prices are generally lower from April to September.

April

Cheapest

Flights from $397

August

Most Expensive

Flights from $947

Apr

Jul

Aug

Sep

Direct flights from San Francisco to Knoxville

Frontier Airlines

Allegiant Air

United Airlines

Last-minute flights going from San Francisco to Knoxville

Thu, Aug 6

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines

$560

$465

One-way

Thu, Aug 6

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Deutsche Luft Hansa

$495

$513

One-way

Sat, Aug 8

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines

$483

$369

One-way

Sat, Aug 8

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Southwest Airlines

$539

$410

One-way

Mon, Aug 10

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines

$457

$349

One-way

Mon, Aug 10

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

American Airlines

$475

$376

One-way

Biggest price drops on these dates for flights from San Francisco to Knoxville

4 nights

Oct 29 - Nov 2

$425 → $250

41%

5 nights

Oct 28 - Nov 2

$422 → $249

41%

2 nights

Oct 31 - Nov 2

$427 → $257

40%

3 nights

Aug 24 - Aug 27

$473 → $326

31%

Popular Airports to fly from San Francisco to Knoxville

San Francisco - Knoxville route insights

💸 Price insights

Recent fares are below the typical level

Recent fares from San Francisco to Knoxville are below the typical level at $249.

📅 Best time to fly

April is historically the cheapest month to fly

Historically, April is the cheapest month to fly from San Francisco to Knoxville, with a median price of $397.

⏱️ Flight duration

Connecting flights average 74h 33m

Connecting flights from San Francisco to Knoxville typically average 74h 33m.

✈️ Airlines & availability

Connecting flights are dominant on this route

Direct flights are not available; connecting flights are dominant with a median of 2 stopovers.

🏆 Airline highlight

Frontier Airlines has 39 direct deals

Frontier Airlines offers 39 direct deals from San Francisco to Knoxville.

🎯 Booking tip

Deals appear regularly for this route

Deals for flights from San Francisco to Knoxville appear regularly, with frequent opportunities to save.

San Francisco main airports to depart from

San Francisco International (SFO)

Cheapest

San Francisco International is a major hub, offering many flight options to Knoxville.

📍 ~18 km from San Francisco city center (reachable by car or train).

💸 Flights from ~$248

Knoxville main airports to arrive at

McGhee Tyson (TYS)

Cheapest

McGhee Tyson Airport is ideal for travelers flying from San Francisco to Knoxville.

📍 ~18 km from city center (reachable by car)

💸 Flights from ~$248

Airports nearby Knoxville used as alternative

Hartsfield–Jackson Atlanta International (ATL)

Cheapest

Hartsfield–Jackson Atlanta International offers unparalleled direct flight options and often provides significant cost savings.

📍 ~290 km from Knoxville (requires a 3.5 to 4-hour drive)

💸 Flights from ~$237

Business & First Class Flight Deals to Knoxville

83% AI deal score

$1,672

$1,277

Save $395

Frequently Asked Questions About Flights to Knoxville

To find more affordable flights, consider being flexible with your travel dates and times. Comparing prices across different airlines and booking platforms can often reveal better deals. Setting up price alerts may also help you catch drops in fares.

Booking in advance can often secure better prices, though last-minute deals sometimes appear. Generally, monitoring prices over several weeks before your intended travel date can help you identify a good time to purchase. Prices can fluctuate based on demand and other factors.

Yes, comparing nearby airports at both your origin and destination can sometimes lead to more affordable flight options. While it may require additional ground transportation, the savings on airfare can sometimes be significant. Always factor in the total cost and convenience.

Related routes

More routes from San Francisco

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Flights to Knoxville from other cities

Flights from Atlanta to Knoxville Flights from Bangkok to Knoxville Flights from Chicago to Knoxville Flights from Dallas to Knoxville Flights from Florence to Knoxville Flights from Houston to Knoxville Flights from Madrid to Knoxville Flights from Milan to Knoxville Flights from Nashville to Knoxville Flights from Rome to Knoxville Flights from Southampton to Knoxville Flights from Venice to Knoxville

San Francisco to Knoxville: Overview

Insights for flights from San Francisco to Knoxville

How much is a round trip from San Francisco to Knoxville

Regular price: $344 - $514

Prices for flights from San Francisco to Knoxville are currently below the regular range.

The regular price range for flights from San Francisco to Knoxville is between $344 and $514. The current lowest deal is $249 with Frontier Airlines for travel from Oct 28-Nov 2.

now $249

Low $344

High $514

The cheapest time to fly from San Francisco to Knoxville

April

Cheapest

Flights from $397

August

Most Expensive

Flights from $947

Apr

Jul

Aug

Sep

Direct flights from San Francisco to Knoxville

Frontier Airlines

Allegiant Air

United Airlines

Last-minute flights going from San Francisco to Knoxville

Thu, Aug 6

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines

$560

$465

One-way

Thu, Aug 6

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Deutsche Luft Hansa

$495

$513

One-way

Sat, Aug 8

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines

$483

$369

One-way

Sat, Aug 8

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Southwest Airlines

$539

$410

One-way

Mon, Aug 10

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines

$457

$349

One-way

Mon, Aug 10

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

American Airlines

$475

$376

One-way

Biggest price drops on these dates for flights from San Francisco to Knoxville

4 nights

Oct 29 - Nov 2

$425 → $250

41%

5 nights

Oct 28 - Nov 2

$422 → $249

41%

2 nights

Oct 31 - Nov 2

$427 → $257

40%

3 nights

Aug 24 - Aug 27

$473 → $326

31%

Popular Airports to fly from San Francisco to Knoxville