Are direct flights from San Francisco to Knoxville always the best option?

Direct flights offer convenience by minimizing travel time and avoiding layovers, but they are not always the cheapest option. Flights with one or more connections can sometimes be significantly more affordable. Weigh the cost savings against the added travel time and potential for delays.

Can flexible travel dates help on San Francisco to Knoxville flights?

Being flexible with your travel dates can significantly impact the price of your flight. Mid-week travel or flying during off-peak seasons often results in lower fares compared to weekends or holidays. Adjusting your departure or return by a day or two may reveal better deals.

What extra costs should I check before booking San Francisco to Knoxville flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. Understanding these additional fees helps you calculate the true total cost of your trip.

Flights From San Francisco

To Knoxville

Cheap Flights from San Francisco to Knoxville

Browse current best options from San Francisco. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

San Francisco

RatePunk searches hundreds of travel sites at once for deals on flights to Knoxville

Prices updated 7 days ago

483 airlines compared

80%+ AI score for best value

Fares are subject to change and may not be available for all dates. (Data last updated Oct 26, 2026.)

Today’s best flight deals from San Francisco to Knoxville

Explore current cheapest deals departing from San Francisco to Knoxville

2027-01-10 – 2027-02-08
SFO - Knoxville
75% AI deal score
$282
$236
Round trip
2027-01-19 – 2027-02-08
SFO - Knoxville
79% AI deal score
$289
$236
Round trip
2027-01-10 – 2027-01-25
SFO - Knoxville
74% AI deal score
$289
$244
Round trip
2027-01-19 – 2027-01-25
SFO - Knoxville
81% AI deal score
$326
$244
Round trip
2027-01-26 – 2027-02-08
SFO - Knoxville
79% AI deal score
$301
$244
Round trip
2027-01-05 – 2027-01-25
SFO - Knoxville
74% AI deal score
$283
$244
Round trip
2027-01-06 – 2027-01-25
SFO - Knoxville
73% AI deal score
$283
$250
Round trip
2027-01-05 – 2027-01-24
SFO - Knoxville
73% AI deal score
$283
$250
Round trip
2027-01-19 – 2027-01-24
SFO - Knoxville
81% AI deal score
$334
$250
Round trip
2027-01-10 – 2027-01-24
SFO - Knoxville
73% AI deal score
$293
$253
Round trip

San Francisco to Knoxville: Overview

Insights for flights from San Francisco to Knoxville

Fares for cheap flights from San Francisco to Knoxville typically range from $534–$890, with a median of $727. Right now, current fares are below the typical level for this route. However, 0% of recent fares were classified as a good price, indicating that finding lower prices can be challenging. Deals are infrequent — a price alert helps to track fluctuations.

When is the cheapest time to fly from San Francisco to Knoxville? The most affordable month to fly is October, with a median fare of $445. Following closely is November, where the median fare is $752. These months present the best opportunities for travelers seeking lower prices on this route.

Most itineraries for flights from San Francisco to Knoxville connect at least once, as 0% of recent fares were non-stop. For connecting itineraries, the typical number of connections is 2. This means travelers should expect to make multiple stops on their journey.

A typical journey from San Francisco to Knoxville takes approximately 11h 19m, including connections. This duration accounts for the layovers and transfers common on this route, given that most itineraries are not direct flights from San Francisco to Knoxville. Travelers should plan accordingly for this travel time.

The distance between San Francisco and Knoxville is 3405 kilometers, classifying this as a medium-haul route. This distance typically involves a significant amount of air travel time, often necessitating connecting flights.

How much is a round trip from San Francisco to Knoxville

Regular price: $250 - $562

Prices for flights from San Francisco to Knoxville are currently below the regular range.

The regular price range for this route is $250-$562. The current lowest deal is $236 with Frontier Airlines, valid for travel from Jan 19-Feb 8.

now $236

Low $250

High $562

The cheapest time to fly from San Francisco to Knoxville

The cheapest month to fly from San Francisco to Knoxville is October, with a median price of $445. The most expensive month is November, with a median price of $752. Generally, prices are lower from October to November.

October

Cheapest

Flights from $445

November

Most Expensive

Flights from $752

Oct

Nov

Direct flights from San Francisco to Knoxville

Frontier Airlines

Allegiant Air

United Airlines

American Airlines

Last-minute flights going from San Francisco to Knoxville

Fri, Oct 30

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines, Allegiant Air

$458

$592

One-way

Fri, Oct 30

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines, Allegiant Air

$478

$664

One-way

Fri, Oct 30

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines, Allegiant Air

$467

$686

One-way

Fri, Oct 30

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines, Allegiant Air

$502

$754

One-way

Fri, Oct 30

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines, Allegiant Air

$546

$831

One-way

Fri, Oct 30

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines, Allegiant Air

$666

$860

One-way

Biggest price drops on these dates for flights from San Francisco to Knoxville

5 nights

Jan 19 - Jan 24

$334 → $250

25%

3 nights

Dec 16 - Dec 19

$442 → $358

19%

4 nights

Nov 12 - Nov 16

$400 → $323

19%

4 nights

Jan 20 - Jan 24

$331 → $261

21%

Popular Airports to fly from San Francisco to Knoxville

San Francisco - Knoxville route insights

💸 Price insights

Recent fares are below the typical level

Recent fares from San Francisco to Knoxville are below the typical level at $236.

📅 Best time to fly

October is historically cheapest at $445

Historically, October is the cheapest month to fly from San Francisco to Knoxville, with a median price of $445.

⏱️ Flight duration

Connecting flights average 11h 19m

Connecting flights from San Francisco to Knoxville typically average 11h 19m, covering a distance of 3405 km.

✈️ Airlines & availability

Connecting flights are dominant

The route from San Francisco to Knoxville is connecting-dominant, with a median of 2 stopovers.

🏆 Airline highlight

Frontier Airlines has 53 deals

Frontier Airlines offers 53 direct deals for flights from San Francisco to Knoxville.

🎯 Booking tip

Deals are rare for this route

Deals for flights from San Francisco to Knoxville are rare, based on the last 30 days.

San Francisco main airports to depart from

San Francisco International (SFO)

Cheapest

San Francisco International is a convenient option for flights from San Francisco to Knoxville.

📍 ~18 km from city center (reachable by car or train)

💸 Flights from ~$224

Knoxville main airports to arrive at

McGhee Tyson (TYS)

Cheapest

McGhee Tyson Airport is ideal for travelers flying from San Francisco to Knoxville.

📍 ~18 km from Knoxville (reachable by car)

💸 Flights from ~$241

Airports nearby Knoxville used as alternative

Hartsfield–Jackson Atlanta International (ATL)

Cheapest

Hartsfield–Jackson Atlanta International offers unparalleled direct flight options and often provides significant cost savings.

📍 ~280 km from Knoxville (reachable by car)

💸 Flights from ~$144

Business & First Class Flight Deals to Knoxville

Discover luxury on the budget with premium cabin class on flights from San Francisco to Knoxville.

Elite

Best Elite deals to Knoxville

Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.

From SFO

Elite

Dec 08

Knoxville, United States

70% AI deal score

$2,332

Porter Airlines, +1

Business Class

From SFO

Elite

Dec 08

Knoxville, United States

70% AI deal score

$2,332

Porter Airlines, +1

Business Class

From SFO

Elite

Dec 15

Knoxville, United States

70% AI deal score

$2,387

Porter Airlines, +1

Business Class

From SFO

Elite

Dec 10

Knoxville, United States

70% AI deal score

$2,401

Porter Airlines, +1

Business Class

From SFO

Elite

Dec 10

Knoxville, United States

70% AI deal score

$2,401

Porter Airlines, +1

Business Class

From SFO

Elite

Nov 18

Knoxville, United States

70% AI deal score

$2,417

Air Transat, +1

Business Class

From SFO

Elite

Dec 08

Knoxville, United States

70% AI deal score

$2,547

Porter Airlines, +1

Business Class

From SFO

Elite

Dec 08

Knoxville, United States

70% AI deal score

$2,595

Porter Airlines, +1

Business Class

From SFO

Elite

Dec 15

Knoxville, United States

70% AI deal score

$2,602

Porter Airlines, +1

Business Class

From SFO

Elite

Dec 10

Knoxville, United States

70% AI deal score

$2,615

Porter Airlines, +1

Business Class

From SFO

Elite

Dec 10

Knoxville, United States

70% AI deal score

$2,663

Porter Airlines, +1

Business Class

From SFO

Elite

Jan 23

Knoxville, United States

69% AI deal score

$2,399

Porter Airlines, +1

Business Class

Frequently Asked Questions About Flights to Knoxville

To find more affordable flights, consider being flexible with your travel dates and times. Comparing prices across different airlines and booking platforms can often reveal better deals. Setting up price alerts may also notify you when fares drop for your desired route.

Booking flights several weeks or months in advance often results in lower prices, especially for popular routes. However, last-minute deals can sometimes appear, so it's wise to monitor fare trends. Mid-week bookings may also offer slight advantages over weekend purchases.

Comparing nearby airports at both your origin and destination can sometimes uncover more affordable flight options. While it may add to your ground travel time, the potential savings on airfare can be significant. Always factor in the total cost and convenience when considering this approach.

Related routes

More routes from San Francisco

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Flights to Knoxville from other cities

Flights from Atlanta to Knoxville Flights from Bangkok to Knoxville Flights from Chicago to Knoxville Flights from Dallas to Knoxville Flights from Florence to Knoxville Flights from Houston to Knoxville Flights from Madrid to Knoxville Flights from Milan to Knoxville Flights from Rome to Knoxville Flights from Southampton to Knoxville Flights from Venice to Knoxville

San Francisco to Knoxville: Overview

Insights for flights from San Francisco to Knoxville

How much is a round trip from San Francisco to Knoxville

Regular price: $250 - $562

Prices for flights from San Francisco to Knoxville are currently below the regular range.

The regular price range for this route is $250-$562. The current lowest deal is $236 with Frontier Airlines, valid for travel from Jan 19-Feb 8.

now $236

Low $250

High $562

The cheapest time to fly from San Francisco to Knoxville

October

Cheapest

Flights from $445

November

Most Expensive

Flights from $752

Oct

Nov

Direct flights from San Francisco to Knoxville

Frontier Airlines

Allegiant Air

United Airlines

American Airlines

Last-minute flights going from San Francisco to Knoxville

Fri, Oct 30

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines, Allegiant Air

$458

$592

One-way

Fri, Oct 30

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines, Allegiant Air

$478

$664

One-way

Fri, Oct 30

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines, Allegiant Air

$467

$686

One-way

Fri, Oct 30

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines, Allegiant Air

$502

$754

One-way

Fri, Oct 30

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines, Allegiant Air

$546

$831

One-way

Fri, Oct 30

⌛ Last-Minute

SFO - Knoxville

San Francisco (SFO) - Knoxville (TYS)

Frontier Airlines, Allegiant Air

$666

$860

One-way

Biggest price drops on these dates for flights from San Francisco to Knoxville

5 nights

Jan 19 - Jan 24

$334 → $250

25%

3 nights

Dec 16 - Dec 19

$442 → $358

19%

4 nights

Nov 12 - Nov 16

$400 → $323

19%

4 nights

Jan 20 - Jan 24

$331 → $261

21%

Popular Airports to fly from San Francisco to Knoxville

San Francisco - Knoxville route insights

💸 Price insights

Recent fares are below the typical level

Recent fares from San Francisco to Knoxville are below the typical level at $236.

📅 Best time to fly

October is historically cheapest at $445

Historically, October is the cheapest month to fly from San Francisco to Knoxville, with a median price of $445.

⏱️ Flight duration

Connecting flights average 11h 19m

Connecting flights from San Francisco to Knoxville typically average 11h 19m, covering a distance of 3405 km.

✈️ Airlines & availability

Connecting flights are dominant

The route from San Francisco to Knoxville is connecting-dominant, with a median of 2 stopovers.

🏆 Airline highlight

Frontier Airlines has 53 deals

Frontier Airlines offers 53 direct deals for flights from San Francisco to Knoxville.

🎯 Booking tip

Deals are rare for this route

Deals for flights from San Francisco to Knoxville are rare, based on the last 30 days.

San Francisco main airports to depart from

San Francisco International (SFO)

Cheapest

San Francisco International is a convenient option for flights from San Francisco to Knoxville.

📍 ~18 km from city center (reachable by car or train)

💸 Flights from ~$224

Knoxville main airports to arrive at

McGhee Tyson (TYS)

Cheapest

McGhee Tyson Airport is ideal for travelers flying from San Francisco to Knoxville.

📍 ~18 km from Knoxville (reachable by car)

💸 Flights from ~$241

Airports nearby Knoxville used as alternative

Hartsfield–Jackson Atlanta International (ATL)

Cheapest

Hartsfield–Jackson Atlanta International offers unparalleled direct flight options and often provides significant cost savings.

📍 ~280 km from Knoxville (reachable by car)

💸 Flights from ~$144

Knoxville, United States

69% AI deal score

$2,399

Porter Airlines, +1

Business Class

Frequently Asked Questions About Flights to Knoxville

Cheap Flights from San Francisco to Knoxville

Today’s best flight deals from San Francisco to Knoxville

San Francisco to Knoxville: Overview

Insights for flights from San Francisco to Knoxville

How much is a round trip from San Francisco to Knoxville

The cheapest time to fly from San Francisco to Knoxville

Direct flights from San Francisco to Knoxville

Last-minute flights going from San Francisco to Knoxville

Biggest price drops on these dates for flights from San Francisco to Knoxville

Popular Airports to fly from San Francisco to Knoxville

San Francisco - Knoxville route insights

Recent fares are below the typical level

October is historically cheapest at $445

Connecting flights average 11h 19m

Connecting flights are dominant

Frontier Airlines has 53 deals

Deals are rare for this route

San Francisco main airports to depart from

Knoxville main airports to arrive at

Airports nearby Knoxville used as alternative

Business & First Class Flight Deals to Knoxville

Best Elite deals to Knoxville

Dec 08

Dec 08

Dec 15

Dec 10

Dec 10

Nov 18

Dec 08

Dec 08

Dec 15

Dec 10

Dec 10

Jan 23

Frequently Asked Questions About Flights to Knoxville

How can I find cheap flights from San Francisco to Knoxville?

When should I book flights from San Francisco to Knoxville?

Should I compare nearby airports for flights from San Francisco to Knoxville?

Are direct flights from San Francisco to Knoxville always the best option?

Can flexible travel dates help on San Francisco to Knoxville flights?

What extra costs should I check before booking San Francisco to Knoxville flights?

Related routes

More routes from San Francisco

Flights to Knoxville from other cities

San Francisco to Knoxville: Overview

Insights for flights from San Francisco to Knoxville

How much is a round trip from San Francisco to Knoxville

The cheapest time to fly from San Francisco to Knoxville

Direct flights from San Francisco to Knoxville

Last-minute flights going from San Francisco to Knoxville

Biggest price drops on these dates for flights from San Francisco to Knoxville

Popular Airports to fly from San Francisco to Knoxville

San Francisco - Knoxville route insights

Recent fares are below the typical level

October is historically cheapest at $445

Connecting flights average 11h 19m

Connecting flights are dominant

Frontier Airlines has 53 deals

Deals are rare for this route

San Francisco main airports to depart from

Knoxville main airports to arrive at

Airports nearby Knoxville used as alternative

Business & First Class Flight Deals to Knoxville

Best Elite deals to Knoxville

Dec 08

Dec 08

Dec 15

Dec 10

Dec 10

Nov 18

Dec 08

Dec 08

Dec 15

Dec 10

Dec 10

Jan 23

Frequently Asked Questions About Flights to Knoxville

How can I find cheap flights from San Francisco to Knoxville?

When should I book flights from San Francisco to Knoxville?

Should I compare nearby airports for flights from San Francisco to Knoxville?