Are direct flights from Guayaquil to Panama City always the best option?

Direct flights usually offer convenience and save travel time. However, flights with layovers can sometimes be more affordable. Evaluate whether the time saved on a direct flight is worth a potentially higher cost for your travel plans.

Can flexible travel dates help on Guayaquil to Panama City flights?

Yes, being flexible with your travel dates can often lead to finding cheaper flights. Prices can vary significantly between different days of the week or even within the same week. Adjusting your departure or return by a day or two may result in savings.

What extra costs should I check before booking Guayaquil to Panama City flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. Factor these into your total travel budget.

Flights From Guayaquil

To Panama City

Cheap Flights from Guayaquil to Panama City

Browse current best options from Guayaquil. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

Guayaquil

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Prices updated 5 days ago

402 airlines compared

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Fares are subject to change and may not be available for all dates. (Data last updated Jul 12, 2026.)

Today’s best flight deals from Guayaquil to Panama City

Explore current cheapest deals departing from Guayaquil to Panama City

Round trip

Sort by: Cheapest

July 16 - July 24

Cheapest

Best

GYE - Panama

$419

$298

Round trip

July 13 - July 16

Earliest

GYE - Panama

$351

$317

Round trip

July 13 - July 18

Earliest

GYE - Panama

$326

$317

Round trip

July 13 - July 20

Earliest

GYE - Panama

$309

$317

Round trip

July 14 - July 16

GYE - Panama

$353

$317

Round trip

July 14 - July 17

GYE - Panama

$351

$317

Round trip

July 14 - July 18

GYE - Panama

$349

$317

Round trip

July 14 - July 19

GYE - Panama

$326

$317

Round trip

July 14 - July 20

GYE - Panama

$309

$317

Round trip

July 14 - July 21

GYE - Panama

$309

$317

Round trip

Unlock all 500+ flight deals to Panama City and get alerts when great deals appear

Guayaquil to Panama City: Overview

Insights for flights from Guayaquil to Panama City

For cheap flights from Guayaquil to Panama City, right now fares are below the typical level. Prices typically range from $897–$1554, with a median of $1120. However, 0% of recent fares were classified as a good price, indicating that finding significantly discounted tickets can be challenging.

The journey from Guayaquil to Panama City covers a distance of 3670 km, classifying it as a medium-haul route. This distance means you should expect a flight that is longer than a short domestic hop but not a full intercontinental trip.

A typical journey from Guayaquil to Panama City takes approximately 23h 53m, including connections. This longer duration is due to the fact that most itineraries connect at least once, with a median of 3 stopovers when connecting. There are currently no direct flights from Guayaquil to Panama City available in recent data.

When is the cheapest time to fly from Guayaquil to Panama City? The most affordable months to fly are typically August, with a median fare of $607, followed by March at $847, and September at $891. Planning your trip during these months could lead to more favorable pricing.

How much is a round trip from Guayaquil to Panama City

Regular price: $287 - $430

Prices are currently within the regular range.

The regular price range for flights is $287 to $430. The current lowest deal is $317 via Kayak, for travel from Jul 14-Jul 16.

now $317

Low $287

High $430

The cheapest time to fly from Guayaquil to Panama City

The cheapest month to fly from GYE to ECP is August, with a median price of $607. The most expensive month is December, with a median price of $2312. Prices are generally lower from January to September.

August

Cheapest

Flights from $607

December

Most Expensive

Flights from $2,312

Jan

Mar

Apr

May

Jun

Jul

Aug

Sep

Oct

Dec

Direct flights from Guayaquil to Panama City

Copa Airlines

Last-minute flights going from Guayaquil to Panama City

Sun, Jul 12

⌛ Last-Minute

GYE - Panama

Guayaquil (GYE) - Panama (PTY)

$351

$317

One-way

Sun, Jul 12

⌛ Last-Minute

GYE - Panama

Guayaquil (GYE) - Panama (PTY)

$326

$317

One-way

Sun, Jul 12

⌛ Last-Minute

GYE - Panama

Guayaquil (GYE) - Panama (PTY)

$309

$317

One-way

Sun, Jul 12

⌛ Last-Minute

GYE - Panama

Guayaquil (GYE) - Panama (PTY)

$309

$317

One-way

Mon, Jul 13

⌛ Last-Minute

GYE - Panama

Guayaquil (GYE) - Panama (PTY)

$353

$317

One-way

Mon, Jul 13

⌛ Last-Minute

GYE - Panama

Guayaquil (GYE) - Panama (PTY)

$351

$317

One-way

Biggest price drops on these dates for flights from Guayaquil to Panama City

2 nights

Sep 25 - Sep 27

$392 → $317

19%

2 nights

Sep 28 - Sep 30

$392 → $317

19%

3 nights

Sep 25 - Sep 28

$391 → $317

19%

4 nights

Sep 25 - Sep 29

$391 → $317

19%

Popular Airports to fly from Guayaquil to Panama City

Guayaquil - Panama City route insights

💸 Price insights

Recent fares are below the typical level

Recent fares from Guayaquil to Panama City are below the typical level at $317.

📅 Best time to fly

August is historically cheapest

Historically, August is the cheapest month to fly, with a median price of $607.

⏱️ Flight duration

Median flight time is 23h 53m

The median flight duration from Guayaquil to Panama City is 23 hours and 53 minutes.

✈️ Airlines & availability

Connecting flights are dominant

Connecting flights are dominant on this route, with a median of 3 stopovers.

🏆 Airline highlight

Copa Airlines offers direct deals

Copa Airlines has offered direct deals on the Guayaquil to Panama City route.

🎯 Booking tip

Deals appear regularly

Deals on flights from Guayaquil to Panama City appear regularly.

Guayaquil main airports to depart from

José Joaquín de Olmedo International (GYE)

Cheapest

Fly from Guayaquil to Panama City with good value fares from José Joaquín de Olmedo International.

📍 ~5 km from city center (reachable by car)

💸 Flights from ~$293

Panama City main airports to arrive at

Northwest Florida Beaches International (ECP)

Cheapest

Arrive at Northwest Florida Beaches International to reach Panama City and surrounding areas.

📍 ~20 km from city center (reachable by car)

💸 Flights from ~$904

Airports nearby Panama City used as alternative

Destin–Fort Walton Beach (VPS)

Destin–Fort Walton Beach Airport is a useful alternative with frequent flight options for your arrival.

📍 ~100 km from Panama City (traffic on Highway 98 can impact travel time).

💸 Flights from ~$599

Pensacola International (PNS)

Cheapest

Pensacola International Airport offers superior connectivity and a full range of cabin classes for your arrival.

📍 ~120 km from Panama City (approximately 1.5 to 2 hours drive).

💸 Flights from ~$526

Tallahassee International (TLH)

Tallahassee International Airport provides consistent regional jet service and reasonable driving distance via I-10.

📍 ~120 km from Panama City (located in a different timezone).

💸 Flights from ~$527

Dothan Regional (DHN)

Dothan Regional Airport offers a simple terminal experience for quick arrivals, with relatively close proximity.

📍 ~100 km from Panama City (very limited flight schedule and destinations).

💸 Flights from ~$2230

Montgomery Regional (MGM)

Montgomery Regional Airport provides additional carrier options for travelers heading north into Alabama.

📍 ~240 km from Panama City (significant driving distance).

💸 Flights from ~$1155

Frequently Asked Questions About Flights to Panama City

To find more affordable flights, consider being flexible with your travel dates and times. Using flight comparison sites can help you compare prices from various airlines and online travel agencies. Look out for deals and promotions that may be available.

Booking in advance often helps secure better prices, especially for popular routes. However, last-minute deals can sometimes appear. It's often recommended to monitor price trends and book when you see a fare that fits your budget.

Comparing nearby airports can sometimes reveal different flight options or prices. While it may add to your ground travel, it could potentially lead to savings. Always consider the total cost and convenience when evaluating this option.

Related routes

Consider alternative routes from Guayaquil

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Cheap Flights from Guayaquil to Panama City

Today’s best flight deals from Guayaquil to Panama City

Unlock all 500+ flight deals to Panama City and get alerts when great deals appear

Guayaquil to Panama City: Overview

Insights for flights from Guayaquil to Panama City

How much is a round trip from Guayaquil to Panama City

The cheapest time to fly from Guayaquil to Panama City

Direct flights from Guayaquil to Panama City

Last-minute flights going from Guayaquil to Panama City

Biggest price drops on these dates for flights from Guayaquil to Panama City

Popular Airports to fly from Guayaquil to Panama City

Guayaquil - Panama City route insights

Recent fares are below the typical level

August is historically cheapest

Median flight time is 23h 53m

Connecting flights are dominant

Copa Airlines offers direct deals

Deals appear regularly

Guayaquil main airports to depart from

Panama City main airports to arrive at

Airports nearby Panama City used as alternative

Frequently Asked Questions About Flights to Panama City

How can I find cheap flights from Guayaquil to Panama City?

When should I book flights from Guayaquil to Panama City?

Should I compare nearby airports for flights from Guayaquil to Panama City?

Are direct flights from Guayaquil to Panama City always the best option?

Can flexible travel dates help on Guayaquil to Panama City flights?

What extra costs should I check before booking Guayaquil to Panama City flights?

Related routes

Consider alternative routes from Guayaquil