Are direct flights from Medellín to Panama City always the best option?

Direct flights offer convenience and save travel time, but they are not always the most budget-friendly choice. Flights with one or more layovers can often be cheaper. Consider your priorities for cost versus travel time when making your selection.

Can flexible travel dates help on Medellín to Panama City flights?

Absolutely, being flexible with your travel dates can significantly impact the price of your flight. Mid-week flights or traveling during the off-peak season for your destination often yield lower fares. Adjusting your departure or return by a few days may reveal more affordable options.

What extra costs should I check before booking Medellín to Panama City flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. Factor these into your total travel budget to avoid surprises.

Flights From Medellín

To Panama City

Cheap Flights from Medellín to Panama City

Browse current best options from Medellín. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

Medellín

RatePunk searches hundreds of travel sites at once for deals on flights to Panama City

Prices updated today

485 airlines compared

80%+ AI score for best value

Fares are subject to change and may not be available for all dates. (Data last updated Nov 2, 2026.)

Today’s best flight deals from Medellín to Panama City

Explore current cheapest deals departing from Medellín to Panama City

2026-11-12 – 2026-11-14
MDE - Panama City
35% AI deal score
$529
$1,494
Round trip
2027-04-08 – 2027-04-17
MDE - Panama City
35% AI deal score
$503
$1,506
Round trip
2026-11-10 – 2026-11-14
MDE - Panama City
35% AI deal score
$535
$1,595
Round trip
2026-11-08 – 2026-11-14
MDE - Panama City
35% AI deal score
$519
$1,601
Round trip
2026-12-15 – 2027-01-06
MDE - Panama City
36% AI deal score
$473
$1,633
Round trip
2026-11-12 – 2026-11-19
MDE - Panama City
35% AI deal score
$493
$1,644
Round trip
2026-11-12 – 2026-11-26
MDE - Panama City
35% AI deal score
$451
$1,646
Round trip
2026-11-19 – 2026-11-26
MDE - Panama City
35% AI deal score
$493
$1,655
Round trip
2026-10-27 – 2026-11-14
MDE - Panama City
35% AI deal score
$547
$1,674
Round trip
2026-11-06 – 2026-11-14
MDE - Panama City
35% AI deal score
$512
$1,681
Round trip

Medellín to Panama City: Overview

How much is a round trip from Medellín to Panama City

Regular price: $568 - $814

Prices for flights from Medellín to Panama City are currently above the regular range.

The regular price range for flights from Medellín to Panama City is typically between $568 and $814. The current lowest deal is $1183 with United Airlines, for travel from Oct 26-Oct 28.

now $1,183

Low $568

High $814

The cheapest time to fly from Medellín to Panama City

The cheapest month to fly from MDE to ECP is October, with a median price of 1512 USD. The most expensive month is March, with a median price of 1766 USD. Prices are generally lower from October to December.

October

Cheapest

Flights from $1,512

March

Most Expensive

Flights from $1,766

Mar

Oct

Nov

Dec

Direct flights from Medellín to Panama City

WestJet

Maersk Air

AeroRepública

Air Transat

Last-minute flights going from Medellín to Panama City

Tue, Nov 10

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

Maersk Air, WestJet

$433

$1,479

One-way

Thu, Nov 12

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

Maersk Air, WestJet

$427

$1,479

One-way

Thu, Nov 19

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

Maersk Air, WestJet

$435

$1,538

One-way

Mon, Nov 30

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

Air Canada, WestJet

$489

$1,894

One-way

Mon, Nov 30

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

Air Canada, WestJet

$443

$2,552

One-way

Tue, Dec 1

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

Copa Airlines, WestJet

$547

$1,531

One-way

Biggest price drops on these dates for flights from Medellín to Panama City

9 nights

Apr 8 - Apr 17

$503 → $1,491

196%

3 nights

Jan 13 - Jan 16

$479 → $1,508

215%

7 nights

Jan 31 - Feb 7

$481 → $1,559

224%

27 nights

Dec 10 - Jan 6

$466 → $1,550

233%

Popular Airports to fly from Medellín to Panama City

Medellín - Panama City route insights

💸 Price insights

Recent fares are below the typical level

Recent fares for Medellín to Panama City are below the typical level.

📅 Best time to fly

November is historically cheapest

Historically, November is the cheapest month to fly from Medellín to Panama City.

⏱️ Flight duration

Connecting flights average 22h 16m

Connecting flights from Medellín to Panama City typically take 22 hours and 16 minutes.

✈️ Airlines & availability

Connecting flights are dominant

Connecting flights are dominant on this route, with a median of 2 stopovers.

🏆 Airline highlight

United Airlines offers a recent deal

United Airlines recently offered a deal for $1183 from Medellín to Panama City via kiwi.

🎯 Booking tip

Deals are rare on this route

Deals for flights from Medellín to Panama City are historically rare.

Medellín main airports to depart from

José María Córdova International (MDE)

Cheapest

José María Córdova International Airport offers flights from Medellín to Panama City, starting from $757.

📍 ~20 km from Medellín (reachable by car)

💸 Flights from ~$757

Olaya Herrera (EOH)

Olaya Herrera Airport is an alternative for flights from Medellín to Panama City, with prices from $1229.

📍 ~3 km from Medellín (reachable by car)

💸 Flights from ~$1,229

Panama City main airports to arrive at

Northwest Florida Beaches International (ECP)

Cheapest

Arrive at Northwest Florida Beaches International for convenient access to Panama City and the surrounding region.

📍 ~26 km from Panama City (reachable by car)

💸 Flights from ~$1,326

Airports nearby Panama City used as alternative

Destin–Fort Walton Beach (VPS)

Destin–Fort Walton Beach is a useful alternative, serving the same coastal region with similar airline carriers.

📍 ~90 km from Panama City (traffic can be heavy during peak tourist seasons).

💸 Flights from ~$680

Business & First Class Flight Deals to Panama City

Discover luxury on the budget with premium cabin class on flights from Medellín to Panama City.

Elite

Best Elite deals to Panama City

Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.

From MDE

Elite

Dec 27

Panama City, United States

66% AI deal score

$3,602

LATAM Chile, +1

Business Class

From MDE

Elite

Dec 28

Panama City, United States

66% AI deal score

$3,634

LATAM Chile, +1

Business Class

From MDE

Elite

Dec 22

Panama City, United States

66% AI deal score

$3,753

LATAM Chile, +1

Business Class

From MDE

Elite

Dec 29

Panama City, United States

66% AI deal score

$3,758

LATAM Chile, +1

Business Class

Frequently Asked Questions About Flights to Panama City

To find more affordable flights, consider being flexible with your travel dates and times. Comparing prices across different airlines and booking sites can often reveal better deals. Looking into flights with layovers instead of direct routes may also present cheaper options.

Booking flights in advance, often several weeks or months before your intended departure, can sometimes result in lower prices. Prices may fluctuate, so monitoring fares over time can help you identify a good booking window. Weekday travel can also sometimes be more affordable than weekend travel.

Yes, comparing nearby airports for both your origin and destination can sometimes lead to more economical flight options. While it may add to your ground travel time, the savings on airfare can sometimes be significant. Always check the total cost and convenience before deciding.

Related routes

More routes from Medellín

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Flights to Panama City from other cities

Flights from Amsterdam to Panama City Flights from Frankfurt to Panama City Flights from Guayaquil to Panama City Flights from Hong Kong to Panama City Flights from Munich to Panama City Flights from Paris to Panama City Flights from Quito to Panama City Flights from Rome to Panama City Flights from San Juan to Panama City Flights from San Miguel de Tucumán to Panama City Flights from Santiago de Chile to Panama City

Medellín to Panama City: Overview

How much is a round trip from Medellín to Panama City

Regular price: $568 - $814

Prices for flights from Medellín to Panama City are currently above the regular range.

The regular price range for flights from Medellín to Panama City is typically between $568 and $814. The current lowest deal is $1183 with United Airlines, for travel from Oct 26-Oct 28.

now $1,183

Low $568

High $814

The cheapest time to fly from Medellín to Panama City

October

Cheapest

Flights from $1,512

March

Most Expensive

Flights from $1,766

Mar

Oct

Nov

Dec

Direct flights from Medellín to Panama City

WestJet

Maersk Air

AeroRepública

Air Transat

Last-minute flights going from Medellín to Panama City

Tue, Nov 10

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

Maersk Air, WestJet

$433

$1,479

One-way

Thu, Nov 12

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

Maersk Air, WestJet

$427

$1,479

One-way

Thu, Nov 19

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

Maersk Air, WestJet

$435

$1,538

One-way

Mon, Nov 30

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

Air Canada, WestJet

$489

$1,894

One-way

Mon, Nov 30

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

Air Canada, WestJet

$443

$2,552

One-way

Tue, Dec 1

⌛ Last-Minute

MDE - Panama City

Medellín (MDE) - Panama City (ECP)

Copa Airlines, WestJet

$547

$1,531

One-way

Biggest price drops on these dates for flights from Medellín to Panama City

9 nights

Apr 8 - Apr 17

$503 → $1,491

196%

3 nights

Jan 13 - Jan 16

$479 → $1,508

215%

7 nights

Jan 31 - Feb 7

$481 → $1,559

224%

27 nights

Dec 10 - Jan 6

$466 → $1,550

233%

Popular Airports to fly from Medellín to Panama City