Are direct flights from Medellín to Panama City always the best option?

Direct flights offer convenience and save travel time, but they are not always the most economical choice. Flights with one or more layovers can often be cheaper, though they will extend your journey. Consider your priorities for cost versus travel duration when making your selection.

Can flexible travel dates help on Medellín to Panama City flights?

Yes, being flexible with your travel dates can significantly impact the price of your flight. Mid-week flights or those during off-peak seasons usually offer lower fares compared to weekends or popular holiday periods. Adjusting your departure or return by even a day or two may lead to savings.

What extra costs should I check before booking Medellín to Panama City flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. Understanding these additional expenses can help you calculate the true total cost of your trip.

Flights From Medellín

To Panama City

Cheap Flights from Medellín to Panama City

Browse current best options from Medellín. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

Medellín

RatePunk searches hundreds of travel sites at once for deals on flights to Panama City

Prices updated 1 day ago

461 airlines compared

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Fares are subject to change and may not be available for all dates. (Data last updated Sep 14, 2026.)

Today’s best flight deals from Medellín to Panama City

Explore current cheapest deals departing from Medellín to Panama City

2027-02-08 – 2027-02-13
MDE - Panama
38% AI deal score
$138
$170
Round trip
2027-02-08 – 2027-02-16
MDE - Panama
38% AI deal score
$136
$170
Round trip
2027-02-14 – 2027-02-19
MDE - Panama
38% AI deal score
$138
$170
Round trip
2027-02-15 – 2027-02-19
MDE - Panama
39% AI deal score
$143
$170
Round trip
2027-01-20 – 2027-01-26
MDE - Panama
41% AI deal score
$178
$172
Round trip
2027-01-17 – 2027-01-31
MDE - Panama
39% AI deal score
$165
$174
Round trip
2027-02-09 – 2027-02-13
MDE - Panama
38% AI deal score
$138
$175
Round trip
2027-02-12 – 2027-02-14
MDE - Panama
37% AI deal score
$138
$182
Round trip
2027-02-12 – 2027-02-20
MDE - Panama
37% AI deal score
$136
$183
Round trip
2027-01-20 – 2027-01-24
MDE - Panama
40% AI deal score
$183
$184
Round trip

Medellín to Panama City: Overview

Insights for flights from Medellín to Panama City

The journey from Medellín to Panama City covers a distance of 2901 kilometers, classifying it as a medium-haul route. This distance means you'll typically be looking at flights that involve a significant travel duration, often with connections.

For cheap flights from Medellín to Panama City, fares are typically $969–$1551, with a median of $1242. Right now, current fares are below the typical level, which can present opportunities for savings. However, the share of recent fares classified as a good price is 0%, indicating that finding exceptionally low prices can be challenging.

When considering the cheapest time to fly from Medellín to Panama City, November stands out with a median fare of $484. Following closely, October offers a median fare of $741, and September presents a median of $773. These months generally offer more favorable pricing compared to other times of the year.

Most itineraries from Medellín to Panama City are connecting_dominant, meaning that almost all flights will involve at least one stopover. When connections are necessary, the typical number of stopovers is 3. This indicates that direct flights from Medellín to Panama City are not common for this route.

A typical journey from Medellín to Panama City takes approximately 22h 16m, including connections. This duration reflects the fact that most itineraries involve multiple stopovers, significantly extending the overall travel time compared to a non-stop flight.

How much is a round trip from Medellín to Panama City

Regular price: $118 - $241

Prices are currently within the regular range.

The regular price range for flights from Medellín to Panama is $118 to $241. The current lowest deal is $170 via Kayak for travel from Feb 8-Feb 13.

now $170

Low $118

High $241

The cheapest time to fly from Medellín to Panama City

The cheapest month to fly from MDE to ECP is November, with a median price of $484. The most expensive month is March, with a median price of $1464. Generally, prices are lower from January to November.

November

Cheapest

Flights from $484

March

Most Expensive

Flights from $1,464

Jan

Mar

Apr

May

Jun

Jul

Sep

Oct

Nov

Direct flights from Medellín to Panama City

AeroRepública

Copa Airlines

Last-minute flights going from Medellín to Panama City

Tue, Sep 15

⌛ Last-Minute

MDE - Panama

Medellín (MDE) - Panama (PTY)

$214

$247

One-way

Tue, Sep 15

⌛ Last-Minute

MDE - Panama

Medellín (MDE) - Panama (PTY)

$260

$291

One-way

Tue, Sep 15

⌛ Last-Minute

MDE - Panama

Medellín (MDE) - Panama (PTY)

$257

$291

One-way

Tue, Sep 15

⌛ Last-Minute

MDE - Panama

Medellín (MDE) - Panama (PTY)

$214

$291

One-way

Wed, Sep 16

⌛ Last-Minute

MDE - Panama

Medellín (MDE) - Panama (PTY)

$234

$286

One-way

Fri, Sep 18

⌛ Last-Minute

MDE - Panama

Medellín (MDE) - Panama (BLB)

$287

$286

One-way

Biggest price drops on these dates for flights from Medellín to Panama City

5 nights

Nov 20 - Nov 25

$335 → $207

38%

4 nights

Sep 14 - Sep 18

$413 → $305

26%

3 nights

Nov 20 - Nov 23

$337 → $238

29%

3 nights

Oct 21 - Oct 24

$304 → $220

28%

Popular Airports to fly from Medellín to Panama City

Medellín - Panama City route insights

💸 Price insights

Recent fares are below the typical level

Recent fares from Medellín to Panama City are below the typical level for this route.

📅 Best time to fly

November is historically cheapest

Historically, November is the cheapest month to fly from Medellín to Panama City, with a median price of $484.

⏱️ Flight duration

Connecting flights average 22h 16m

Connecting flights from Medellín to Panama City typically average 22 hours and 16 minutes.

✈️ Airlines & availability

Connecting flights are dominant

Connecting flights are dominant on this route, with a median of 3 stopovers when connecting.

🏆 Airline highlight

AeroRepública and Copa Airlines offer deals

AeroRepública and Copa Airlines have historically offered deals on this route.

🎯 Booking tip

Deals are frequent on this route

Deals on flights from Medellín to Panama City are frequent, appearing within a 30-day window.

Medellín main airports to depart from

José María Córdova International (MDE)

Cheapest

José María Córdova International Airport offers flights to Panama City, with prices from $168.

📍 ~20 km from Medellín (reachable by car)

💸 Flights from ~$168

Panama City main airports to arrive at

Northwest Florida Beaches International (ECP)

Cheapest

Arrive at Northwest Florida Beaches International for convenient access to Panama City and the surrounding region.

📍 ~26 km from Panama City (reachable by car)

💸 Flights from ~$841

Airports nearby Panama City used as alternative

Destin–Fort Walton Beach (VPS)

Destin–Fort Walton Beach (VPS) is a useful alternative, serving the same coastal region with similar airline carriers.

📍 ~90 km from Panama City (reachable by car, but traffic can be heavy).

💸 Flights from ~$610

Business & First Class Flight Deals to Panama City

Discover luxury on the budget with premium cabin class on flights from Medellín to Panama City.

Elite

Best Elite deals to Panama City

Exclusive daily First Class, Business Class, and Premium Economy flight deals, refreshed every 24 hours.

From MDE

Elite

Sep 24

Panama City, United States

68% AI deal score

$2,747

Aeroméxico, +1

Business Class

From MDE

Elite

Sep 24

Panama City, United States

68% AI deal score

$2,769

Aeroméxico, +1

Business Class

From MDE

Elite

Sep 24

Panama City, United States

68% AI deal score

$2,784

Aeroméxico, +1

Business Class

From MDE

Elite

Sep 24

Panama City, United States

68% AI deal score

$2,786

Aeroméxico, +1

Business Class

From MDE

Elite

Sep 24

Panama City, United States

68% AI deal score

$2,800

Aeroméxico, +1

Business Class

From MDE

Elite

Sep 24

Panama City, United States

68% AI deal score

$2,801

Aeroméxico, +1

Business Class

From MDE

Elite

Sep 24

Panama City, United States

68% AI deal score

$2,816

Aeroméxico, +1

Business Class

From MDE

Elite

Sep 24

Panama City, United States

68% AI deal score

$2,822

Aeroméxico, +1

Business Class

From MDE

Elite

Sep 24

Panama City, United States

68% AI deal score

$2,840

Aeroméxico, +1

Business Class

From MDE

Elite

Sep 24

Panama City, United States

68% AI deal score

$2,859

Aeroméxico, +1

Business Class

From MDE

Elite

Sep 24

Panama City, United States

67% AI deal score

$2,894

Aeroméxico, +1

Business Class

From MDE

Elite

Oct 03

Panama City, United States

67% AI deal score

$3,034

Aeroméxico, +1

Business Class

Frequently Asked Questions About Flights to Panama City

To find more affordable flights, consider being flexible with your travel dates and times. Comparing prices across different airlines and booking sites can often reveal better deals. Looking into flights with layovers instead of direct routes may also present cheaper options.

Booking flights in advance, often several weeks or months before your intended departure, can sometimes result in lower prices. Prices may fluctuate, so monitoring fares over time can help you identify a good booking window. Weekday travel can also sometimes be more economical than weekend travel.

Comparing nearby airports for both your origin and destination can sometimes uncover more budget-friendly flight options. While it may add to your ground travel, the savings on airfare can occasionally be significant. Always factor in the additional time and cost of transportation to and from these alternative airports.

Related routes

More routes from Medellín

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Flights to Panama City from other cities

Flights from Amsterdam to Panama City Flights from Barcelona to Panama City Flights from Bogotá to Panama City Flights from Frankfurt to Panama City Flights from Munich to Panama City Flights from Paris to Panama City Flights from Quito to Panama City Flights from Reykjavik to Panama City Flights from Rome to Panama City Flights from San Juan to Panama City Flights from San Miguel de Tucumán to Panama City Flights from Santiago de Chile to Panama City

Medellín to Panama City: Overview

Insights for flights from Medellín to Panama City

How much is a round trip from Medellín to Panama City

Regular price: $118 - $241

Prices are currently within the regular range.

The regular price range for flights from Medellín to Panama is $118 to $241. The current lowest deal is $170 via Kayak for travel from Feb 8-Feb 13.

now $170

Low $118

High $241

The cheapest time to fly from Medellín to Panama City

November

Cheapest

Flights from $484

March

Most Expensive

Flights from $1,464

Jan

Mar

Apr

May

Jun

Jul

Sep

Oct

Nov

Direct flights from Medellín to Panama City

AeroRepública

Copa Airlines

Last-minute flights going from Medellín to Panama City

Tue, Sep 15

⌛ Last-Minute

MDE - Panama

Medellín (MDE) - Panama (PTY)

$214

$247

One-way

Tue, Sep 15

⌛ Last-Minute

MDE - Panama

Medellín (MDE) - Panama (PTY)

$260

$291

One-way

Tue, Sep 15

⌛ Last-Minute

MDE - Panama

Medellín (MDE) - Panama (PTY)

$257

$291

One-way

Tue, Sep 15

⌛ Last-Minute

MDE - Panama

Medellín (MDE) - Panama (PTY)

$214

$291

One-way

Wed, Sep 16

⌛ Last-Minute

MDE - Panama

Medellín (MDE) - Panama (PTY)

$234

$286

One-way

Fri, Sep 18

⌛ Last-Minute

MDE - Panama

Medellín (MDE) - Panama (BLB)

$287

$286

One-way

Biggest price drops on these dates for flights from Medellín to Panama City

5 nights

Nov 20 - Nov 25

$335 → $207

38%

4 nights

Sep 14 - Sep 18

$413 → $305

26%

3 nights

Nov 20 - Nov 23

$337 → $238

29%

3 nights

Oct 21 - Oct 24

$304 → $220

28%

Popular Airports to fly from Medellín to Panama City

Medellín - Panama City route insights

💸 Price insights

Recent fares are below the typical level

Recent fares from Medellín to Panama City are below the typical level for this route.

📅 Best time to fly

November is historically cheapest

Historically, November is the cheapest month to fly from Medellín to Panama City, with a median price of $484.

⏱️ Flight duration

Connecting flights average 22h 16m

Connecting flights from Medellín to Panama City typically average 22 hours and 16 minutes.

✈️ Airlines & availability

Connecting flights are dominant

Connecting flights are dominant on this route, with a median of 3 stopovers when connecting.

🏆 Airline highlight

AeroRepública and Copa Airlines offer deals

AeroRepública and Copa Airlines have historically offered deals on this route.

🎯 Booking tip

Deals are frequent on this route

Deals on flights from Medellín to Panama City are frequent, appearing within a 30-day window.

Medellín main airports to depart from

José María Córdova International (MDE)

Cheapest

José María Córdova International Airport offers flights to Panama City, with prices from $168.

📍 ~20 km from Medellín (reachable by car)

💸 Flights from ~$168

Panama City main airports to arrive at

Northwest Florida Beaches International (ECP)

Cheapest

Arrive at Northwest Florida Beaches International for convenient access to Panama City and the surrounding region.

📍 ~26 km from Panama City (reachable by car)

💸 Flights from ~$841

Airports nearby Panama City used as alternative

Destin–Fort Walton Beach (VPS)

Destin–Fort Walton Beach (VPS) is a useful alternative, serving the same coastal region with similar airline carriers.

📍 ~90 km from Panama City (reachable by car, but traffic can be heavy).

💸 Flights from ~$610

Panama City, United States

67% AI deal score

$3,034

Aeroméxico, +1

Business Class

Frequently Asked Questions About Flights to Panama City

Cheap Flights from Medellín to Panama City

Today’s best flight deals from Medellín to Panama City

Medellín to Panama City: Overview

Insights for flights from Medellín to Panama City

How much is a round trip from Medellín to Panama City

The cheapest time to fly from Medellín to Panama City

Direct flights from Medellín to Panama City

Last-minute flights going from Medellín to Panama City

Biggest price drops on these dates for flights from Medellín to Panama City

Popular Airports to fly from Medellín to Panama City

Medellín - Panama City route insights

Recent fares are below the typical level

November is historically cheapest

Connecting flights average 22h 16m

Connecting flights are dominant

AeroRepública and Copa Airlines offer deals

Deals are frequent on this route

Medellín main airports to depart from

Panama City main airports to arrive at

Airports nearby Panama City used as alternative

Business & First Class Flight Deals to Panama City

Best Elite deals to Panama City

Sep 24

Sep 24

Sep 24

Sep 24

Sep 24

Sep 24

Sep 24

Sep 24

Sep 24

Sep 24

Sep 24

Oct 03

Frequently Asked Questions About Flights to Panama City

How can I find cheap flights from Medellín to Panama City?

When should I book flights from Medellín to Panama City?

Should I compare nearby airports for flights from Medellín to Panama City?

Are direct flights from Medellín to Panama City always the best option?

Can flexible travel dates help on Medellín to Panama City flights?

What extra costs should I check before booking Medellín to Panama City flights?

Related routes

More routes from Medellín

Flights to Panama City from other cities

Medellín to Panama City: Overview

Insights for flights from Medellín to Panama City

How much is a round trip from Medellín to Panama City

The cheapest time to fly from Medellín to Panama City

Direct flights from Medellín to Panama City

Last-minute flights going from Medellín to Panama City

Biggest price drops on these dates for flights from Medellín to Panama City

Popular Airports to fly from Medellín to Panama City

Medellín - Panama City route insights

Recent fares are below the typical level

November is historically cheapest

Connecting flights average 22h 16m

Connecting flights are dominant

AeroRepública and Copa Airlines offer deals

Deals are frequent on this route

Medellín main airports to depart from

Panama City main airports to arrive at

Airports nearby Panama City used as alternative

Business & First Class Flight Deals to Panama City

Best Elite deals to Panama City

Sep 24

Sep 24

Sep 24

Sep 24

Sep 24

Sep 24

Sep 24

Sep 24

Sep 24

Sep 24

Sep 24

Oct 03

Frequently Asked Questions About Flights to Panama City

How can I find cheap flights from Medellín to Panama City?

When should I book flights from Medellín to Panama City?

Should I compare nearby airports for flights from Medellín to Panama City?