Are direct flights from Rome to Panama City always the best option?

Direct flights offer convenience and save time, but they are not always the most economical choice. Flights with layovers can often be cheaper, especially for longer distances. Weigh the trade-off between travel time and cost to find what suits your needs.

Can flexible travel dates help on Rome to Panama City flights?

Yes, having flexible travel dates can significantly increase your chances of finding cheaper flights. Prices often vary greatly depending on the day of the week or season. Flying during off-peak times or mid-week can frequently lead to better deals.

What extra costs should I check before booking Rome to Panama City flights?

Before booking, always check for potential extra costs such as baggage fees, seat selection charges, and in-flight services. Some airlines may also charge for printing boarding passes at the airport. Factor these into your total travel budget.

Flights From Rome

To Panama City

Cheap Flights from Rome to Panama City

Browse current best options from Rome. Become a member to unlock all deals and get alerts when new deals appear.

Deals from

Rome

RatePunk searches hundreds of travel sites at once for deals on flights to Panama City

Prices updated 2 days ago

405 airlines compared

80%+ AI score for best value

Fares are subject to change and may not be available for all dates. (Data last updated Jul 26, 2026.)

Today’s best flight deals from Rome to Panama City

Explore current cheapest deals departing from Rome to Panama City

2026-10-04 – 2026-10-11
ROM - Panama City
83% AI deal score
985 €
803 €
Round trip
2026-08-01 – 2026-08-08
ROM - Panama City
83% AI deal score
1,221 €
974 €
Round trip
2026-08-24 – 2026-09-03
ROM - Panama City
79% AI deal score
1,064 €
977 €
Round trip
2026-08-29 – 2026-09-16
ROM - Panama City
72% AI deal score
1,042 €
1,055 €
Round trip
2026-09-14 – 2026-09-17
ROM - Panama City
75% AI deal score
986 €
1,069 €
Round trip
2026-09-14 – 2026-09-16
ROM - Panama City
72% AI deal score
988 €
1,119 €
Round trip
2026-09-09 – 2026-09-16
ROM - Panama City
71% AI deal score
955 €
1,129 €
Round trip
2026-09-02 – 2026-09-16
ROM - Panama City
71% AI deal score
912 €
1,149 €
Round trip
2026-08-15 – 2026-08-31
ROM - Panama City
73% AI deal score
1,057 €
1,301 €
Round trip

Rome to Panama City: Overview

How much is a round trip from Rome to Panama City

Regular price: €846 - €1,294

Prices are currently below the regular range.

The regular price range for flights from Rome to Panama City is 846 EUR to 1294 EUR. The current lowest deal is 808 EUR with United Airlines for travel from Oct 4-Oct 11.

now 808 €

Low 846 €

High 1,294 €

The cheapest time to fly from Rome to Panama City

The cheapest month to fly from Rome to Panama City is November, with a median price of $728. The most expensive month is June, with a median price of $3880. Prices are generally lower from August to November.

November

Cheapest

Flights from 728 €

June

Most Expensive

Flights from 3,880 €

Jun

Jul

Aug

Sep

Nov

Direct flights from Rome to Panama City

United Airlines

WestJet

Air Transat

Aer Lingus

Last-minute flights going from Rome to Panama City

Tue, Aug 4

⌛ Last-Minute

FCO - Panama City

Rome (FCO) - Panama City (ECP)

Alitalia, KLM

1,112 €

2,502 €

One-way

Tue, Aug 4

⌛ Last-Minute

FCO - Panama City

Rome (FCO) - Panama City (ECP)

Alitalia, KLM

1,112 €

2,767 €

One-way

Wed, Aug 5

⌛ Last-Minute

FCO - Panama City

Rome (FCO) - Panama City (ECP)

Alitalia, KLM

1,114 €

2,670 €

One-way

Wed, Aug 5

⌛ Last-Minute

FCO - Panama City

Rome (FCO) - Panama City (ECP)

Alitalia, KLM

1,108 €

2,935 €

One-way

Sat, Aug 22

⌛ Last-Minute

FCO - Panama City

Rome (FCO) - Panama City (ECP)

Alitalia, KLM

1,212 €

2,422 €

One-way

Sat, Aug 22

⌛ Last-Minute

FCO - Panama City

Rome (FCO) - Panama City (ECP)

Alitalia, KLM

1,205 €

2,576 €

One-way

Biggest price drops on these dates for flights from Rome to Panama City

4 nights

Sep 18 - Sep 22

999 € → 771 €

23%

12 nights

Sep 9 - Sep 21

917 € → 1,006 €

10%

5 nights

Sep 16 - Sep 21

984 € → 1,153 €

17%

6 nights

Sep 15 - Sep 21

959 € → 1,129 €

18%

Popular Airports to fly from Rome to Panama City

Rome - Panama City route insights

💸 Price insights

Recent fares are below the typical level

Recent fares from Rome to Panama City are €808, below the typical level of €992.

📅 Best time to fly

Fly in November for the best prices

Historically, November is the cheapest month to fly from Rome to Panama City, with a median price of $728.

⏱️ Flight duration

Flights are typically 15h 13m long

The typical flight duration from Rome to Panama City is 15h 13m.

✈️ Airlines & availability

United Airlines offers the most deals

United Airlines offers the most direct deals on this route, followed by WestJet and Air Transat.

🏆 Airline highlight

United Airlines has 10 deals

United Airlines has historically offered 10 deals for flights from Rome to Panama City.

🎯 Booking tip

Deals are rare for this route

Deals on flights from Rome to Panama City are rare, appearing within a 30-day window.

Rome main airports to depart from

Leonardo da Vinci–Fiumicino Airport (FCO)

Cheapest

Consider FCO for flights from Rome to Panama City, offering a good balance of convenience and value.

📍 ~20 km from Rome city center (reachable by car, bus, or train)

💸 Flights from ~$715

Ciampino–G. B. Pastine International (CIA)

CIA is an alternative departure airport for your journey from Rome to Panama City.

📍 ~15 km from Rome city center (reachable by car or bus)

💸 Flights from ~$715

Panama City main airports to arrive at

Northwest Florida Beaches International (ECP)

Cheapest

Northwest Florida Beaches International Airport is a good choice for reaching Panama City.

📍 ~20 km from Panama City (reachable by car)

💸 Flights from ~$725

Airports nearby Panama City used as alternative

Destin–Fort Walton Beach (VPS)

Cheapest

Consider Destin–Fort Walton Beach for a nearby alternative, offering frequent flight options to Panama City.

📍 ~95 km from Panama City (reachable by car, though traffic on Highway 98 can significantly impact travel time).

💸 Flights from ~$672

Business & First Class Flight Deals to Panama City

Discover luxury on the budget with premium cabin class on flights from Rome to Panama City.

Panama City, United States

72% AI deal score

$3,564

Frequently Asked Questions About Flights to Panama City

To find more affordable flights, consider being flexible with your travel dates and times. Comparing prices across different airlines and booking sites can often reveal better deals. Setting up price alerts may also notify you of fare drops.

Booking in advance, often several months before your intended travel date, can sometimes result in lower fares. However, prices can fluctuate, so monitoring trends may help you decide the optimal booking time. Mid-week bookings might also offer slight advantages.

Comparing nearby airports at both your origin and destination can sometimes uncover more affordable flight options. While it may add to your travel time, the potential savings on airfare can be significant. Always factor in ground transportation costs and convenience.

Related routes

More routes from Rome

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Flights to Panama City from other cities

Flights from Amsterdam to Panama City Flights from Barcelona to Panama City Flights from Bogotá to Panama City Flights from Frankfurt to Panama City Flights from Guayaquil to Panama City Flights from Hong Kong to Panama City Flights from Lisbon to Panama City Flights from Madrid to Panama City Flights from Quito to Panama City Flights from San Juan to Panama City Flights from San Miguel de Tucumán to Panama City Flights from Santiago de Chile to Panama City

Rome to Panama City: Overview

How much is a round trip from Rome to Panama City

Regular price: €846 - €1,294

Prices are currently below the regular range.

The regular price range for flights from Rome to Panama City is 846 EUR to 1294 EUR. The current lowest deal is 808 EUR with United Airlines for travel from Oct 4-Oct 11.

now 808 €

Low 846 €

High 1,294 €

The cheapest time to fly from Rome to Panama City

November

Cheapest

Flights from 728 €

June

Most Expensive

Flights from 3,880 €

Jun

Jul

Aug

Sep

Nov